Background:
A higher CD4 count among people with HIV (PWH) is associated with improved immune function and reduced HIV-related morbidity and mortality. The purpose of this analysis is to report the trend in CD4 count among PWH in New York City (NYC).
Methods:
We conducted a serial cross-sectional analysis using the NYC HIV registry data and reported the proportion of PWH with a CD4 count of 500 cells/mm3 or above, overall and by sex, race or ethnicity, and age.
Results:
The overall proportion of PWH in NYC with a CD4 count of 500 cells/mm3 or above increased from 38.1% in 2007 to 63.8% in 2021. Among males, the proportion increased from 36.7% in 2007 to 62.3% in 2021 with an annual percentage change (APC) of 6.6% (95% CI: 5.8, 7.5) in 2007–2013 and 2.6% (95% CI: 0.7, 4.4) in 2013–2017, and no changes in 2017–2021 (APC: 0.0%; 95% CI: -1.1, 1.0); among females, the proportion increased from 41.0% in 2007 to 67.6% in 2021 with an APC of 7.5% (95% CI: 5.2, 9.8) in 2007–2010, 4.5% (95% CI: 3.5, 5.4) in 2010–2015, and 0.8% (95% CI: 0.4, 1.2) in 2015–2021. White people had a higher proportion than other racial/ethnic groups, 70.9%, 59.3%, 60.9%, and 61.7%, respectively, among White, Black, Latino/Hispanic, and Asian/Pacific Islander males, and 69.8%, 68.0%, 66.3%, and 69.3%, respectively, among White, Black, Latina/Hispanic, and Asian/Pacific Islander females in 2021.
Conclusions:
CD4 count among PWH in NYC improved during 2007–2021, but the improvement slowed in recent years.