Beyond immediate hypersensitivity: evolving roles for IgE antibodies in immune homeostasis and allergic diseases

Burton, Oliver T.; Oettgen, Hans C.

doi:10.1111/j.1600-065x.2011.01024.x

Cited by 126 publications

(106 citation statements)

References 141 publications

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“…Previous studies have shown that the number of FceRI receptors on mast cells greatly increases in the presence of elevated serum IgE levels. 18 Thus, it is possible that what appeared to be cytoplasmic localization of IgE in our immunostaining experiments may have actually been the result of very high levels of membrane-associated IgE. However, a few reports have suggested that antigen cross-linking could lead to the aggregation and internalization of FceRI.…”

Section: Discussionmentioning

confidence: 84%

T helper 2 and regulatory T-cell cytokine production by mast cells: a key factor in the pathogenesis of IgG4-related disease

et al. 2014

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IgG4-related disease is a systemic disorder with unique clinicopathological features and uncertain etiological features and is frequently related to allergic disease. T helper 2 and regulatory T-cell cytokines have been reported to be upregulated in the affected tissues; thus, the production of these cytokines by T helper 2 and regulatory T cells has been suggested as an important factor in the pathogenesis of IgG4-related disease. However, it is not yet clear which cells produce these cytokines in IgG4-related disease, and some aspects of the disorder cannot be completely explained by T-cell-related processes. To address this, we analyzed paraffinembedded sections of tissues from nine cases of IgG4-related submandibular gland disease, five cases of submandibular sialolithiasis, and six cases of normal submandibular gland in order to identify potential key players in the pathogenesis of IgG4-related disease. Real-time polymerase chain reaction analysis confirmed the significant upregulation of interleukin (IL)4, IL10, and transforming growth factor beta 1 (TGFb1) in IgG4-related disease. Interestingly, immunohistochemical studies indicated the presence of mast cells expressing these cytokines in diseased tissues. In addition, dual immunofluorescence assays identified cells that were double-positive for each cytokine and for KIT, which is expressed by mast cells. In contrast, the distribution of T cells did not correlate with cytokine distribution in affected tissues. We also found that the mast cells were strongly positive for IgE. This observation supports the hypothesis that mast cells are involved in IgG4-related disease, as mast cells are known to be closely related to allergic reactions and are activated in the presence of elevated non-specific IgE levels. In conclusion, our results indicate that mast cells produce T helper 2 and regulatory T-cell cytokines in tissues affected by IgG4-related disease and possibly have an important role in disease pathogenesis.

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Section: Discussionmentioning

confidence: 84%

T helper 2 and regulatory T-cell cytokine production by mast cells: a key factor in the pathogenesis of IgG4-related disease

et al. 2014

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“…However, IgE antibodies play other important activities in protective immunity against parasites, also influencing the expression of their own receptors FceRI and CD23 as well as mast cell function homoeostasis (8) . Besides IgE, the role of innate immunity has also been re-evaluated in the pathogenesis of allergic disease.…”

mentioning

confidence: 99%

“…IgE antibody production represents the major event contributing to immediate hypersensitivity reactions based on the degranulation of basophils and mast cells with liberation of noxious mediators in various organs (lungs, intestine and skin) (8) . However, IgE antibodies play other important activities in protective immunity against parasites, also influencing the expression of their own receptors FceRI and CD23 as well as mast cell function homoeostasis (8) .…”

mentioning

confidence: 99%

Influence of polyphenols on allergic immune reactions: mechanisms of action

Magrone

Jirillo

2012

Proc. Nutr. Soc.

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The increased incidence of allergic disease seems to rely on many factors. Among them, the association between genetic variations of the immune response and environmental pressure by allergens, infectious agents and pollutants should be taken into consideration. In alternative to conventional treatments with corticosteroids and antihistaminics, nutraceuticals have been shown to act on allergic disease either during allergic sensitisation or on consolidated disease. In this review, special emphasis is placed on the effects of dietary polyphenols on three major allergic diseases, namely atopic eczema, food allergy and asthma. Interference of polyphenols with T-helper 2 activation seems to be the main mechanism of their inhibitory effects on allergy development. Moreover, deficits of T-regulatory cells seem to play a pathogenic role in allergic disease and, therefore, these cells may represent a major target of polyphenol activity

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“…Considering the important role IgE plays in both allergic responses and helminth infections, the total serum IgE concentration was measured. As expected, these levels were higher in S. mansonipositive and/or prick test-positive subjects than in their negative counterparts 28 . Intragroup differences in optical density may be due to low responsiveness or variation in genetic characteristics of certain individuals and/or unknown allergies.…”

Section: Discussionmentioning

confidence: 48%

Association between allergic responses and Schistosoma mansoni infection in residents in a low-endemic setting in Brazil

Oliveira

Bezerra

Carneiro

et al. 2014

Rev. Soc. Bras. Med. Trop.

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Beyond immediate hypersensitivity: evolving roles for IgE antibodies in immune homeostasis and allergic diseases

Cited by 126 publications

References 141 publications

T helper 2 and regulatory T-cell cytokine production by mast cells: a key factor in the pathogenesis of IgG4-related disease

T helper 2 and regulatory T-cell cytokine production by mast cells: a key factor in the pathogenesis of IgG4-related disease

Influence of polyphenols on allergic immune reactions: mechanisms of action

Association between allergic responses and Schistosoma mansoni infection in residents in a low-endemic setting in Brazil

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