Beyond homeosis—HOX function in morphogenesis and organogenesis

Hombría, James Castelli-Gair; Lovegrove, Bridget

doi:10.1046/j.1432-0436.2003.7108004.x

Cited by 167 publications

(144 citation statements)

References 87 publications

Supporting

Mentioning

139

Contrasting

Unclassified

Order By: Relevance

“…We thus propose that the dmOAZ gene is implicated in shaping this structure. Our data suggest that in the genetic cascade of posterior spiracle development (Hombria and Lovegrove 2003), dmOAZ is acting downstream of ct and ems. The proteins encoded by the three genes are co-localized in subsets of spiracular chamber cells.…”

Section: Discussionmentioning

confidence: 66%

“…j Proposed genetic cascade controlling spiracular chamber formation (cf. Hu and Castelli-Gair 1999;Hombria and Lovegrove 2003). DmOAZ appears to be a secondary target of Abd-B, downstream of the cut and ems.…”

Section: Generation Of a Dmoaz Loss-of-function Mutationmentioning

confidence: 99%

“…Ectopic Abd-B expression may induce ectopic filzkörper structures and associated spiracular hairs in thoracic and abdominal segments (Lamka et al 1992;Castelli-Gair et al 1994). Downstream of Abd-B, five early target genes [sal, cut (ct), empty spiracles (ems), klumpfuss (klu), and nubbin (nub)] and four secondary target genes [engrailed (en), grain (grn), trachealess (trh), and grainy head (grh)] were identified (Hu and Castelli-Gair 1999;Hombria and Lovegrove 2003). Whereas sal, en, and grn are implied in stigmatophore development, the remaining genes are involved in spiracular chamber formation.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

DmOAZ, the unique Drosophila melanogaster OAZ homologue is involved in posterior spiracle development

et al. 2007

View full text Add to dashboard Cite

In this paper, we study DmOAZ, the unique Drosophila melanogaster homologue of the OAZ zinc finger protein family. We show partial conservation of the zinc finger organization between DmOAZ and the vertebrate members of this family. We determine the exon/intron structure of the dmOAZ gene and deduce its open reading frame. Reverse transcriptase-polymerase chain reaction analysis shows that dmOAZ is transcribed throughout life. In the embryo, strongest DmOAZ expression is observed in the posterior spiracles. We suggest that dmOAZ acts as a secondary target of the Abd-B gene in posterior spiracle development, downstream of cut and ems. In a newly created loss-of-function mutant, dmOAZ 93 , the "filzkörper" part of the posterior spiracles, is indeed structurally abnormal. The dmOAZ 93 mutant is a larval lethal, a phenotype that may be linked to the spiracular defect. Given the dmOAZ 93 mutant as a new tool, the fruit fly may provide an alternative model for analyzing in vivo the functions of OAZ family members.

show abstract

Section: Discussionmentioning

confidence: 66%

Section: Generation Of a Dmoaz Loss-of-function Mutationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

DmOAZ, the unique Drosophila melanogaster OAZ homologue is involved in posterior spiracle development

et al. 2007

View full text Add to dashboard Cite

show abstract

“…It might depend on the cell type, ranging from one in the embryonic precursors of oenocytes or Keilin's organs 6,26 to plausibly hundreds in the haltere. [27][28][29] Fourth, recent data suggest that Hox genes could affect morphogenesis independently of homeosis, 30 increasing the complexity of the picture. Finally, and perhaps most importantly, the number of model systems to assess Hox function at cellular and molecular levels remains relatively low, urging the need of new ones.…”

Section: Old Question In Search Of New Modelsmentioning

confidence: 99%

Downstream of Homeotic Genes: In the Heart of Hox function

Monier

Tevy²,

Perrin³

et al. 2007

Fly

View full text Add to dashboard Cite

show abstract

“…Hox genes encode an evolutionarily conserved family of transcription factors that function as critical regulators of axial patterning (reviewed in Krumlauf, 1994;Manak and Scott, 1994) and organogenesis (reviewed in Hombria et al, 2003). They act to differentiate and pattern embryonic structures by promoting proliferation of specific cell types.…”

Section: Hox Family-relatives Working Togethermentioning

confidence: 99%