Beyond energy storage: roles of glycogen metabolism in health and disease

Zhang, Huafeng; Ma, Jingwei; Tang, Ke; Huang, Bo

doi:10.1111/febs.15648

Cited by 38 publications

(41 citation statements)

References 110 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The liver is the center of human material and energy metabolism and the most important organ for glucose metabolism. For glucose metabolism, the liver is the center of hepatic glycogen synthesis and gluconeogenesis, and glucose uptake mediated by GLUT1 is essential for this process (82)(83)(84)(85)(86)(87)(88)(89). At the same time, HCC is derived from normal liver cells, and HCC not only has more vigorous material and energy metabolism, but also has the characteristics of aerobic glycolysis and Warburg (47).…”

Section: Discussionmentioning

confidence: 99%

A Novel Microcrystalline BAY-876 Formulation Achieves Long-Acting Antitumor Activity Against Aerobic Glycolysis and Proliferation of Hepatocellular Carcinoma

et al. 2021

View full text Add to dashboard Cite

BAY-876 is an effective antagonist of the Glucose transporter type 1 (GLUT1) receptor, a mediator of aerobic glycolysis, a biological process considered a hallmark of hepatocellular carcinoma (HCC) together with cell proliferation, drug-resistance, and metastasis. However, the clinical application of BAY-876 has faced many challenges. In the presence study, we describe the formulation of a novel microcrystalline BAY-876 formulation. A series of HCC tumor models were established to determine not only the sustained release of microcrystalline BAY-876, but also its long-acting antitumor activity. The clinical role of BAY-876 was confirmed by the increased expression of GLUT1, which was associated with the worse prognosis among advanced HCC patients. A single dose of injection of microcrystalline BAY-876 directly in the HCC tissue achieved sustained localized levels of Bay-876. Moreover, the single injection of microcrystalline BAY-876 in HCC tissues not only inhibited glucose uptake and prolonged proliferation of HCC cells, but also inhibited the expression of epithelial-mesenchymal transition (EMT)-related factors. Thus, the microcrystalline BAY-876 described in this study can directly achieve promising localized effects, given its limited diffusion to other tissues, thereby reducing the occurrence of potential side effects, and providing an additional option for advanced HCC treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

A Novel Microcrystalline BAY-876 Formulation Achieves Long-Acting Antitumor Activity Against Aerobic Glycolysis and Proliferation of Hepatocellular Carcinoma

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In general, M1 polarization of murine macrophages is associated with a metabolism dependent on aerobic glycolysis, whereas in M2 macrophages, the glycolytic activity remains unchanged, and metabolism mainly relies on fatty acid oxidation (FAO) [2,54]. Glycogen metabolism is also crucial for several immune cell types, including macrophages [55]. Induction of glycogen synthesis has been reported together with its degradation in inflammatory macrophages [56].…”

Section: Different Metabolic Reprogramming According To Cell Type Spmentioning

confidence: 99%

“…Recent work has shown that it also plays an important role in polarizing M1 macrophages by feeding the pentose phosphate pathway (PPP) [56], increasing the amount of intracellular NADPH supporting inflammatory macrophages survival. The glycogen metabolic intermediate UDP-glucose (UDPG) also promotes STAT1 induction and phosphorylation via the purinergic receptor P2Y14 in macrophages [55].…”

Section: Different Metabolic Reprogramming According To Cell Type Spmentioning

confidence: 99%

Reprogramming of Central Carbon Metabolism in Myeloid Cells upon Innate Immune Receptor Stimulation

Perrin-Cocon¹,

Diaz²,

Aublin-Gex³

et al. 2021

Immuno

View full text Add to dashboard Cite

Immunometabolism is a relatively new field of research that aims at understanding interconnections between the immune system and cellular metabolism. This is now well-documented for innate immune cells of the myeloid lineage such as macrophages and myeloid dendritic cells (DCs) when they engage their differentiation or activation programs. Several studies have shown that stimulation of DCs or macrophages by the binding of pathogen-associated molecular patterns (PAMPs) to pattern recognition receptors (PRRs) leads to increased glycolytic activity and rewiring of central carbon metabolism. These metabolic modulations are essential to support and settle immunological functions by providing energy and immunoregulatory metabolites. As the understanding of molecular mechanisms progressed, significant differences between cell types and species have also been discovered. Pathways leading to the regulation of central carbon metabolism in macrophages and DCs by PRR signaling and consequences on cellular functions are reviewed here.

show abstract

“…Glycogen is a highly branched polysaccharide that is widely distributed across species from prokaryotes to eukaryotes ( Wilson et al, 2010 ), which plays pivotal roles in a variety of extremely important functions, such as energy reserve ( Greenberg et al, 2006 ), osmotic pressure maintenance ( Brown, 2004 ), host colonization ( Jones et al, 2008 ), blood glucose homeostasis ( Han et al, 2016 ), pH maintenance ( Fredricks et al, 2014 ) and tumor development ( Zhang et al, 2020 ). Since its first discovery by the French physiologist Claude Bernard in 1857, the structure and function of glycogen have been extensively characterized over the centuries, which leads to the grants of multiple Nobel prizes ( Brewer and Gentry, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

From Prokaryotes to Eukaryotes: Insights Into the Molecular Structure of Glycogen Particles

Liu

Tang

Wen

et al. 2021

Front. Mol. Biosci.

View full text Add to dashboard Cite

Glycogen is a highly-branched polysaccharide that is widely distributed across the three life domains. It has versatile functions in physiological activities such as energy reserve, osmotic regulation, blood glucose homeostasis, and pH maintenance. Recent research also confirms that glycogen plays important roles in longevity and cognition. Intrinsically, glycogen function is determined by its structure that has been intensively studied for many years. The recent association of glycogen α-particle fragility with diabetic conditions further strengthens the importance of glycogen structure in its function. By using improved glycogen extraction procedures and a series of advanced analytical techniques, the fine molecular structure of glycogen particles in human beings and several model organisms such as Escherichia coli, Caenorhabditis elegans, Mus musculus, and Rat rattus have been characterized. However, there are still many unknowns about the assembly mechanisms of glycogen particles, the dynamic changes of glycogen structures, and the composition of glycogen associated proteins (glycogen proteome). In this review, we explored the recent progresses in glycogen studies with a focus on the structure of glycogen particles, which may not only provide insights into glycogen functions, but also facilitate the discovery of novel drug targets for the treatment of diabetes mellitus.

show abstract

Beyond energy storage: roles of glycogen metabolism in health and disease

Cited by 38 publications

References 110 publications

A Novel Microcrystalline BAY-876 Formulation Achieves Long-Acting Antitumor Activity Against Aerobic Glycolysis and Proliferation of Hepatocellular Carcinoma

A Novel Microcrystalline BAY-876 Formulation Achieves Long-Acting Antitumor Activity Against Aerobic Glycolysis and Proliferation of Hepatocellular Carcinoma

Reprogramming of Central Carbon Metabolism in Myeloid Cells upon Innate Immune Receptor Stimulation

From Prokaryotes to Eukaryotes: Insights Into the Molecular Structure of Glycogen Particles

Contact Info

Product

Resources

About