2022
DOI: 10.3348/jksr.2021.0177
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Beyond Coronary CT Angiography: CT Fractional Flow Reserve and Perfusion

Abstract: 심장 전산화단층촬영은 비약적인 기술발전과 다양한 연구 결과를 바탕으로 심혈관위험 계층화와 치료 결정을 위한 관상동맥 질환의 진단과 예후 평가성능이 입증되었다. 전산화단층촬영 관상동맥조영술은 폐쇄성 관상동맥 질환에 대한 음성 예측도가 높아서 침습적 혈관조영술의 빈도를 줄일 수 있는 관상동맥 질환 관련 검사의 관문으로 부상했지만, 진단특이도가 상대적으로 낮다. 하지만 심장 전산화단층촬영을 이용한 분획혈류예비력과 심근관류를 분석하여 관상동맥 질환의 혈역학적 유의성을 확인하는 기능적 평가를 통해 그 한계를 극복할 수 있다. 최근에는 이를 보다 객관적이고 재현 가능하도록 인공지능을 접목하는 연구들이 활발히 진행되고 있다. 본 종설에서는 심장 전산화단층촬영의 기능적 영상화 기법들에 대해 알아보고자 한다.

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Cited by 2 publications
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“…clinical scenario allows us to exclude a significant obstructive CAD when symptoms suggestive of myocardial ischemia are present (Figure 1). The low specificity of CCTA in determining the functional significance of identified coronary stenosis has been overcome by the introduction of CT stress myocardial perfusion imaging or CT-guided fractional flow reserve (FFR) computed tomography angiography (Figures 2 and 3) [42][43][44]. The ADVANCE study results highlighted the presence of gender differences in the functional significance of coronary stenosis since women have a higher CT-FFR with the same degree of stenosis than their male counterparts [43].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…clinical scenario allows us to exclude a significant obstructive CAD when symptoms suggestive of myocardial ischemia are present (Figure 1). The low specificity of CCTA in determining the functional significance of identified coronary stenosis has been overcome by the introduction of CT stress myocardial perfusion imaging or CT-guided fractional flow reserve (FFR) computed tomography angiography (Figures 2 and 3) [42][43][44]. The ADVANCE study results highlighted the presence of gender differences in the functional significance of coronary stenosis since women have a higher CT-FFR with the same degree of stenosis than their male counterparts [43].…”
Section: Introductionmentioning
confidence: 99%
“…The low specificity of CCTA in determining the functional significance of identified coronary stenosis has been overcome by the introduction of CT stress myocardial perfusion imaging or CT-guided fractional flow reserve (FFR) computed tomography angiography (Figures 2 and 3) [42][43][44]. The ADVANCE study results highlighted the presence of gender differences in the functional significance of coronary stenosis since women have a higher CT-FFR with the same degree of stenosis than their male counterparts [43]. The low specificity of CCTA in determining the functional significance of identified coronary stenosis has been overcome by the introduction of CT stress myocardial perfusion imaging or CT-guided fractional flow reserve (FFR) computed tomography angiography (Figures 2 and 3) [42][43][44].…”
Section: Introductionmentioning
confidence: 99%