“…A crucial aspect of macro-systems is also their efficient deployment on heterogeneous infrastructures across the edge-cloud continuum ( Casadei et al, 2022 ; Júnior et al, 2022 ). Another key theme is the integration of artificial collective systems with humans, leading to notions like human-in-the-loop cyber-physical systems ( Annaswamy et al, 2023 ), social machines ( Hendler and Berners-Lee, 2010 ), and complex socio-cognitive systems ( Galesic et al, 2023 ). Last but not least, given CPCs are quite peculiar systems due to their complexity, they come with new challenges and opportunities regarding digital twins ( Casadei et al, 2021 ), security and privacy ( Aldini, 2018 ), and green computing ( Stolfi and Alba, 2018 ).…”