Beyond calorie restriction: aging as a biological target for nutrient therapies

Nutritional reprogramming of mouse liver proteome is dampened by metformin, resveratrol, and rapamycin

“…More recently, the effects of manipulating dietary macronutrients have been studied. Protein restriction was found to extend lifespan while high fat diets and high protein diets may accelerate aging and reduce lifespan (Austad and Hoffman, 2021;Simpson et al, 2017). The interaction between protein and carbohydrate intake is also important.…”

A Comparison of Gene Expression Profiles of Rat Tissues after Mild and Short-Term Calorie Restrictions

“…Many studies have shown that calorie restriction (CR) has beneficial health effects on rodents and human [ 1 , 2 ]. Several molecular mechanisms, including the oxidative stress stimulation and nutrient-sensing pathways, have been proposed to explain the role of CR for improving health and extending life [ 3 ].…”

Biological mechanisms of aging predict age‐related disease co‐occurrence in patients

“…Aging is the major risk factor for many chronic and fatal human diseases, including Alzheimer's disease, multiple cancers, cardiovascular diseases, and type 2 diabetes mellitus (T2DM), which are collectively known as age-related diseases (ARDs) (Niccoli & Partridge, 2012). However, genetic (Kenyon, 2010), environmental (Austad & Hoffman, 2020), and pharmacological (Partridge et al, 2020) interventions can ameliorate loss of function during aging and confer resistance to multiple age-related diseases in laboratory animals. Age-related multimorbidity, the presence of more than one ARD in an individual, is posing a major and increasing challenge to healthcare systems worldwide (Pearson-Stuttard et al, 2019).…”