Beyond Arthritis: Understanding the Influence of Gout on Erectile Function: A Systematic Review

Park, Kyle; Gupta, Nikhil; Olweny, Ephrem O.; Schlesinger, Naomi

doi:10.1016/j.urology.2020.12.005

Cited by 7 publications

(6 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Indeed, another study showed increased rates of erectile dysfunction not only following diagnosis of gout, but even in the year previous to diagnosis [ 75 ]. This evidence is suggestive of some common pathogenetic mechanisms among the two different conditions [ 23 ]. The role of hyperuricemia as a potential cardiovascular risk factor should not be overlooked, as UA can promote the development of hypertension, atherosclerosis, fibrillation, and heart failure [ 76 ]: however, a recent meta-analysis study has highlighted that hyperuricemia, while potentially independently contributing to endothelial dysfunction, is more likely to be a reliable marker of systemic dysmetabolic disorders which might negatively affect erectile function [ 77 ].…”

Section: Resultsmentioning

confidence: 93%

See 1 more Smart Citation

Relationship between hyperuricemia with deposition and sexual dysfunction in males and females

Sansone

Reisman

Jannini

2022

J Endocrinol Invest

View full text Add to dashboard Cite

Purpose The association between gout, the most common crystal arthropathy, and sexual dysfunctions has often been investigated by studies in the last decades. Despite the presence of shared risk factors and comorbidities and the possible effects on sexual health of long-term gout complications, awareness of this association is severely lacking and the pathogenetic mechanisms have only partially been identified. In the present review, we aimed to investigate the current evidence regarding the potential mechanisms linking sexual dysfunctions and gout. Methods A comprehensive literature search within PubMed was performed to provide a summary of currently available evidence regarding the association between gout and sexual dysfunctions. Results Gout and sexual dysfunctions share several risk factors, including diabesity, chronic kidney disease, hypertension, metabolic syndrome, and peripheral vascular disease. Gout flares triggered by intense inflammatory responses feature severe pain and disability, resulting in worse sexual function, and some, but not all, treatments can also impair sexual health. Long-term gout complications can result in persistent pain and disability due to joint deformity, fractures, or nerve compression, with negative bearing on sexual function. The presence of low-grade inflammation impairs both sex steroids synthesis and endothelial function, further advancing sexual dysfunctions. The psychological burden of gout is another issue negatively affecting sexual health. Conclusions According to currently available evidence, several biological and psychological mechanisms link sexual dysfunctions and gout. Addressing risk factors and providing adequate treatment could potentially have beneficial effects on both conditions. Appropriate clinical evaluation and multidisciplinary approach are recommended to improve patient care.

show abstract

Section: Resultsmentioning

confidence: 93%

“…ED has several known risk factors, both organic, such as endocrine, cardiovascular, neurological, metabolic, or iatrogenic [ 13 , 15 – 19 ], and non-organic [ 20 – 22 ]. A strong association exists between gout and ED, largely owing to the shared comorbidities, risk factors, and pathophysiological mechanisms [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Relationship between hyperuricemia with deposition and sexual dysfunction in males and females

Sansone

Reisman

Jannini

2022

J Endocrinol Invest

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…Previous clinical studies (Barassi et al, 2018; Salem et al, 2014) have reported a positive relationship between serum urate level and the risk and severity of ED, that is, an increase of 1 mg/dl in serum uric acid was associated with doubled risk of ED (OR 2.07, 95% CI [1.63–2.64]). ULT is the mainstay of gout treatment which including some medicines, for example, febuxostat, benzbromarone, allopurinol and probenecid Lowering the UA level to a target less than 6.8 mg/dl promotes the dissolution of monosodium urate crystals and prevents further gout flares (Park et al, 2021). Allopurinol, febuxostat, probenecid and benzbromarone are the commonly used uric acid‐lowering drugs.…”

Section: Discussionmentioning

confidence: 99%

Hyperuricaemia is an important risk factor of the erectile dysfunction: A systematic review and meta‐analysis

et al. 2022

View full text Add to dashboard Cite

Serum uric acid can affect endothelial function, and hyperuricaemia‐induced endothelial dysfunction is involved in the pathogenesis of cardiovascular diseases. As endothelial dysfunction is also a main pathogenic mechanism of erectile dysfunction (ED), the present study aims to evaluate the relationship between hyperuricaemia and ED via systemic review and meta‐analysis. Five cohort studies and six cross‐sectional studies on hyperuricaemia and ED, including a total of 454,510 participants, were recruited. Odds ratio (OR) and the 95% confidence intervals (CI) were adopted to estimate the relationship between hyperuricaemia and ED. Overall risk on effects of urate‐lowering therapy (ULT) were analysed. In addition, subgroup analyses on study design, populations, age stratification and the object were conducted. In the patients with hyperuricaemia, the risk of ED was 1.59‐fold higher than (pooled OR = 1.59, 95% CI [1.29, 1.97]) the non‐hyperuricaemia counterparts. Urate‐lowing therapy (ULT) in these hyperuricaemia patients reduced the risk of ED by 27% (OR = 1.27, 95% CI [1.14, 1.41]). After subgroup analysis, the association between hyperuricaemia and ED remained significant apart from the >60 years subgroup. Hyperuricaemia is an important risk factor of ED, while ULT can reduce the risk of ED in hyperuricaemia. This study suggests that hyperuricaemia‐associated endothelial dysfunction may also underlie the pathogenesis of ED in these patients.

show abstract

“…Hyperuricemia and gout have been demonstrated to induce endothelial dysfunction, which is the common pathogenesis of vascular ED 9,10 . Some cohort studies have demonstrated that ED incidence was signi cantly higher in patients with hyperuricemia or gout compared to those without hyperuricemia or gout 11,12 . Although considerable evidence supports the correlation of UA levels and gout in ED, the role of UA levels and gout in ED is still controversial.…”

Section: Introductionmentioning

confidence: 99%

Causal association between erectile dysfunction with urate levels and gout: a two-sample Mendelian randomization study

Gao,

Zhu,

Pan

et al. 2023

Preprint

View full text Add to dashboard Cite

Background A plethora of studies have demonstrated that the level of uric acid (UA) and gout are the risk factors for erectile dysfunction (ED). However, the causal effect of UA level and gout on ED is still unclear. Objectives This Mendelian randomization (MR) study aims to examine the bidirectional causality between ED and UA levels as well as gout. Materials and methods We performed a bidirectional MR analysis using summary statistics from genome-wide association studies (GWAS) to investigate the causal association between ED and UA levels as well as gout. We meticulously selected single nucleotide polymorphisms (SNPs) based on rigorous criteria as instrumental variables. Four two-sample MR analysis methods, including inverse-variance weighted (IVW), MR-Egger, weighted median, and weighted mode, were applied in our study. Furthermore, several sensitivity analyses including Cochrane's Q-test, MR-Egger intercept test, MR-PRESSO global test, and leave-one-out analysis were performed to assess heterogeneity, horizontal pleiotropy, and stability. Results The study included one dataset related to UA levels (GWAS meta-analysis conducted by Tin et al.), two datasets related to gout (ukb-b-12765 and finn-R9-M13_GOUT), and one dataset related to ED (GWAS meta-analysis conducted by Bovijn et al.). MR results of the IVW method indicated that UA levels and gout were not causally associated with ED in three UA levels/gout-related datasets (IVW, odds ratio [OR]: 0.99, 95% confidence interval [CI]: 0.92 − 1.07, P = 0.834; 3.20, 0.17–61.69, 0.441; 1.03, 0.97–1.09, 0.372, respectively). The reverse MR revealed no evidence of a causal effect of ED on UA levels or gout according to the IVW method (OR: 0.99, 95%CI: 0.96–1.02, P: 0,568; 1.00, 1.00–1.00, 0.555; 0.97, 0.89–1.05, 0.425, respectively). The results of other MR analysis methods were consistent with IVW. Furthermore, sensitivity analysis suggested that the results were robust, with no pleiotropy or heterogeneity detected. Conclusion Our MR study supports no bidirectional causal effect of UA level or gout on ED.

show abstract

Beyond Arthritis: Understanding the Influence of Gout on Erectile Function: A Systematic Review

Cited by 7 publications

References 47 publications

Relationship between hyperuricemia with deposition and sexual dysfunction in males and females

Relationship between hyperuricemia with deposition and sexual dysfunction in males and females

Hyperuricaemia is an important risk factor of the erectile dysfunction: A systematic review and meta‐analysis

Causal association between erectile dysfunction with urate levels and gout: a two-sample Mendelian randomization study

Contact Info

Product

Resources

About