Beyond a motor disorder: A prospective evaluation of sleep quality in cervical dystonia

Eichenseer, Sheila R.; Stebbins, Glenn T.; Comella, Cynthia L.

doi:10.1016/j.parkreldis.2014.01.004

Cited by 54 publications

(82 citation statements)

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“…Sleep disorders were reported commonly in patients with dystonia (Avanzino et al., 2010; Eichenseer et al., 2014). Avanzino et al.…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have provided convincing evidence that NMS are important predictors for quality of life in dystonia (Ben‐Shlomo et al., 2002; Eichenseer et al., 2014; Page, Butler, & Jahanshahi, 2007; Pekmezovic et al., 2009). A study using “36‐item short‐form healthy survey (SF‐36)” scale found anxiety and depression are the strongest predictors for quality of life in CD (Ben‐Shlomo et al., 2002), which was supported by the studies on patients with various forms of primary dystonia (Page et al., 2007; Pekmezovic et al., 2009).…”

Section: Introductionmentioning

confidence: 99%

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Nonmotor symptoms in primary adult‐onset cervical dystonia and blepharospasm

et al. 2016

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BackgroundThe nature and frequency of nonmotor symptoms in primary adult‐onset cervical dystonia (CD) and blepharospasm (BSP) patients in Chinese populations remain unknown.MethodsHamilton's Depression Scale (HAMD), Hamilton's Anxiety Scale (HAMA), Addenbrooke's Cognitive Examination Revised (ACE‐R), Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale were used to evaluate NMS in 120 patients with primary focal adult‐onset dystonia (60 with BSP and 60 with CD) and 60 age‐, sex‐, and education level‐ matched healthy controls (HCs). Motor symptoms of BSP and CD patients were evaluated by Jankovic rating scale and Toronto Western Spasmodic Torticollis Rating Scale‐severity scale separately.ResultsTwenty patients had depression, and 29 patients had anxiety. The mean HAMD and HAMA scores were significantly higher in patient groups. Thirty‐six patients had cognitive decline based on the cut‐off score of 75. The total score and scores of each domain of ACE‐R were significantly lower in patient groups than that in HCs. Quality of sleep was impaired in patient groups, and patients with CD had worse quality of sleep than patients with BSP. Thirty‐three BSP patients and 43 CD patients suffered from sleep disorder separately. The frequency of excessive daytime sleepiness did not differ between patients and HCs. No significant correlation was found between NMS and motor severity in the two forms of dystonia.ConclusionsCurrent study suggests that NMS are prevalent in Chinese CD and BSP patients, and the motor severity of dystonia did not contribute to the severity of nonmotor symptoms. Assessment of nonmotor symptoms should be considered in clinical management of focal dystonia

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“…Sleep disorders were reported commonly in patients with dystonia (Avanzino et al., 2010; Eichenseer et al., 2014). Avanzino et al.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nonmotor symptoms in primary adult‐onset cervical dystonia and blepharospasm

et al. 2016

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“…В целом распространенность нарушений сна у паци-ентов с фокальными формами дистонии колеблется между 40 и 70% [29,30].…”

Section: расстройства снаunclassified

“…Однако подавляющая часть пациентов, кроме этого, получает лечение другими лекар-ственными препаратами. Так, Eichenseer в исследовании 54 пациентов с цервикальной дистонией отметил исполь-зование следующих лекарственных средств: у 35% -бен-зодиазепины, у 20% -антидепрессанты, у 7% -баклофен, у 4% -антихолинергические препараты [30]. Бензодиа зе-пины и агонисты бензодиазепиновых рецепторов исполь-зуются для лечения коротких эпизодов нарушения сна [31].…”

Section: расстройства снаunclassified

“…Во-первых, тяжесть дистонии не коррелирует с жалобами на сон [25][26][27]. Во-вторых, согласно данным Eichenseer, качество сна после введения ботулинического токсина не улучшается, несмотря на значимое улучшение со стороны двигательной функции [30]. В-третьих, в нескольких исследованиях продемонстрировано, что частота и про-должительность патологических движений значительно снижается во время сна [34][35][36].…”

Section: расстройства снаunclassified

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Focal Dystonias: Non-Motor Symptoms and Comorbidities

Толмачёва¹

2017

Med. sov.

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Дистония является распространенным экстрапирамидным заболеванием. Для нее характерны как моторные, так и немоторные проявления, к которым относятся боль, сенсорные нарушения, избыточная двигательная активность. Обсуждается вклад тревож-ных и депрессивных расстройств, нарушений сна в течение фокальной дистонии. Нередко именно немоторные проявления являются начальными симптомами дистонии. В ряде случаев немоторные проявления можно выделить в самостоятельные заболевания, которые сопутствуют дистоническому гиперкинезу и способствуют ухудшению качества жизни таких больных. Лечение немоторных симптомов позволит повысить эффективность терапии дистонии, а также повлиять на течение заболевания.Ключевые слова: дистония, немоторные симптомы, коморбидность, лечение. V.A. TOLMACHYOVA, PhD in medicine, Sechenov First Moscow State Medical University FOCAL DYSTONIAS: NON-MOTOR SYMPTOMS AND COMORBIDITIESDystonia is a common extrapyramidal disease. It is characterized by both motor and non-motor manifestations, which include pain, sensory disorders and excessive physical activity. The contribution of disturbing and depressed disorders, sleep disorders during the focal dystonia has been discussed. It is often the non-motor manifestations that are the initial symptoms of dystonia. In some cases, unmotorized manifestations can be isolated diseases that accompany dystonic hyperkinesis and contribute to the deterioration of the quality of life of such patients. Treatment of nonmotor symptoms will improve the effectiveness of dystonia therapy as well as affect the course of the disease.

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Validation of a self‐completed Dystonia Non‐Motor Symptoms Questionnaire

Klingelhoefer

Kamm

Martinez‐Martín

et al. 2019

Ann Clin Transl Neurol

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ObjectiveTo develop and validate a novel 14‐item self‐completed questionnaire (in English and German) enquiring about the presence of non‐motor symptoms (NMS) during the past month in patients with craniocervical dystonia in an international multicenter study.MethodsThe Dystonia Non‐Motor Symptoms Questionnaire (DNMSQuest) covers seven domains including sleep, autonomic symptoms, fatigue, emotional well‐being, stigma, activities of daily living, sensory symptoms. The feasibility and clinimetric attributes were analyzed.ResultsData from 194 patients with CD (65.6% female, mean age 58.96 ± 12.17 years, duration of disease 11.95 ± 9.40 years) and 102 age‐ and sex‐matched healthy controls (66.7% female, mean age 55.67 ± 17.62 years) were collected from centres in Germany and the UK. The median total NMS score in CD patients was 5 (interquartile range 3–7), significantly higher than in healthy controls with 1 (interquartile range 0.75–2.25) (P < 0.001, Mann–Whitney U‐test). Evidence for intercorrelation and convergent validity is shown by moderate to high correlations of total DNMSQuest score with motor symptom severity (TWSTRS: r s = 0.61), clinical global impression (r s = 0.40), and health‐related quality of life measures: CDQ‐24 (r s = 0.74), EQ‐5D index (r s = −0.59), and scale (r s = −0.49) (all P < 0.001). Data quality and acceptability was very satisfactory.InterpretationThe DNMSQuest, a patient self‐completed questionnaire for NMS assessment in CD patients, appears robust, reproducible, and valid in clinical practice showing a tangible impact of NMS on quality of life in CD. As there is no specific, comprehensive, validated tool to assess the burden of NMS in dystonia, the DNMSQuest can bridge this gap and could easily be integrated into clinical practice.

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Beyond a motor disorder: A prospective evaluation of sleep quality in cervical dystonia

Cited by 54 publications

References 14 publications

Nonmotor symptoms in primary adult‐onset cervical dystonia and blepharospasm

Nonmotor symptoms in primary adult‐onset cervical dystonia and blepharospasm

Focal Dystonias: Non-Motor Symptoms and Comorbidities

Validation of a self‐completed Dystonia Non‐Motor Symptoms Questionnaire

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