Bewegungsstörungen

Ceballos-Baumann, Andrés; Schwarz, Michael; Wessel, K.; Meyring, S.

doi:10.1007/3-540-31176-9_39

Cited by 4 publications

(5 citation statements)

References 183 publications

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“…In contrast, the primary SMC and posterior SMA showed an impaired activation pattern. 15,16 Our study demonstrates that the prevention of dystonic head turn by the application of a sensory stimulus modifies the activity of frontal brain areas and reduces significantly the activity of the anterior SMA, the premotor cortex, and even the primary SMC contralateral to the dystonic head rotation responsible for this direction of head movement. 26 Thus, the application of the trick maneuver results in a diminished motor unit recruitment and a decreased drive of dystonic head deviation.…”

Section: Changes Of Motor Cortex Activation Patterns Contralateral Tomentioning

confidence: 71%

“…Previous rCBF PET activation studies 15,25 have shown that dystonic postures in patients were associated with an overactivity of the contralateral premotor cortex and the anterior SMA, including the ipsilateral dorsolateral prefrontal cortex if decision making was required for the individual task. In contrast, the primary SMC and posterior SMA showed an impaired activation pattern.…”

Section: Changes Of Motor Cortex Activation Patterns Contralateral Tomentioning

confidence: 99%

“…Each scanning lasted 120 seconds in 30-second frames. More than 10 minutes (five half-lives of 15 O) elapsed between the scans, for sufficient decay of residual radioactivity. The 120 seconds of data were summed.…”

Section: Data Acquisitionmentioning

confidence: 99%

“…14 Positron emission tomographic (PET) activation studies are a valuable tool to study activation of central motor pathways and have improved our understanding of the pathophysiology of dystonia. These regional cerebral blood flow (rCBF) studies have shown that idiopathic dystonia is associated with an increased activation of the contralateral premotor and prefrontal cortex including the anterior supplementary motor area (SMA) 15 whereas posterior SMA and primary sensorimotor cortex (SMC) activation is impaired. 15,16 However, the brain areas involved in an effective sensory trick in dystonia patients are hitherto unknown.…”

mentioning

confidence: 99%

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Sensory tricks in cervical dystonia: Perceptual dysbalance of parietal cortex modulates frontal motor programming

et al. 2000

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Cervical dystonia is a disabling basal ganglia disorder characterized by an involuntary head deviation to one side. A typical but also mysterious feature is the impressive improvement of muscle spasms and involuntary head posture by application of a sensory facial stimulus (sensory trick). Here, we report the effect of a sensory trick on cortical activation patterns in 7 patients with cervical dystonia by using H2(15)O positron emission tomography. The application of the sensory trick stimulus, resulting in a near-neutral head position, led to an increased activation mainly of the superior and inferior parietal lobule (ipsilateral to the original head turn) and bilateral occipital cortex and to a decreased activity of the supplementary motor area and the primary sensorimotor cortex (contralateral to the head turn). We propose that a perceptual dysbalance induced by a sensory trick maneuver leads to a relative displacement of the egocentric midvertical reference to the opposite side and a decrease in motor cortex activity. This modulation of motor programming gives novel insights into the mechanisms involved in sensorimotor integration in movement disorders.

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Section: Changes Of Motor Cortex Activation Patterns Contralateral Tomentioning

confidence: 71%

Section: Changes Of Motor Cortex Activation Patterns Contralateral Tomentioning

confidence: 99%

Section: Data Acquisitionmentioning

confidence: 99%

mentioning

confidence: 99%

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Sensory tricks in cervical dystonia: Perceptual dysbalance of parietal cortex modulates frontal motor programming

et al. 2000

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“…In clinical routine, controlled‐release (CR) levodopa is effective and frequently administered to treat nocturnal akinesia in PD [23,24]. Here, we address the question whether 200/50 mg of CR levodopa/carbidopa has an additional impact on insomnia in PD by restoring the abnormal structure of sleep.…”

Section: Introductionmentioning

confidence: 99%