Beware of Underlying Malignancy: Acquired Ichthyosis

Word, Andrew P.; Cayce, Rachael; Pandya, Amit G.

doi:10.1016/j.amjmed.2013.12.009

Cited by 20 publications

(5 citation statements)

References 10 publications

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“…49,61 For example, in many cases of paraneoplastic AI, appropriate chemotherapy or surgical intervention correlated with AI resolution. 26,27,32,33,38,[96][97][98][99] In other cases, withdrawal of an offending medication was curative. 69,70,[78][79][80]82,85 Conversely, patients undergoing treatment for CML or ALL with ponatinib, drug cessation was not a reasonable option as many had disease refractory to other standard chemotherapy regimens.…”

Section: Agnosis a N D M A Nage M E N Tmentioning

confidence: 99%

“…As with the heritable forms of ichthyosis, topical emollients and keratolytics may provide temporary relief for patients with AI; however, identifying and addressing the underlying aetiology remain the definitive solution 49,61 . For example, in many cases of paraneoplastic AI, appropriate chemotherapy or surgical intervention correlated with AI resolution 26,27,32,33,38,96–99 . In other cases, withdrawal of an offending medication was curative 69,70,78–80,82,85 …”

Section: Diagnosis and Managementmentioning

confidence: 99%

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Acquired ichthyosis, asteatotic dermatitis or xerosis? An update on pathoetiology and drug‐induced associations

Park

Saeidian

Youssefian

et al. 2022

Acad Dermatol Venereol

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Acquired ichthyosis (AI) or conditions mimicking ichthyosis have been documented for well over a century. AI is limited to the skin, but can be the first presenting sign of an underlying disease or an adverse effect of select medications or environmental exposures. 1,2 Most heritable ichthyoses, with the exceptions of late-onset ichthyosis vulgaris (IV) and Refsum disease, typically manifest between the immediate postnatal period and 5 years of age. 2 AI, however, does not follow an obvious age distribution; rather, the appearance and disappearance of AI tend to coincide with onset and resolution of an inciting factor. Clinically, AI closely resembles IV with diffuse, symmetrically distributed, white-to-brown scales which can be confused with severe cases of xerosis or eczema (Figure 1a-c). 1 Histopathology of AI usually shows varying degrees of orthohyperkeratosis, a uniformly diminished or absent granular layer, and lack of dermal inflammation. 1,3 In patients with suspected AI, a detailed investigation into the clinical course typically does not yield personal or family history of ichthyosis, atopy, keratosis pilaris or other keratodermaassociated phenotypes seen with the heritable ichthyoses. 1,2 In this article, we provide an up-to-date overview of AI and the pathomechanisms suggested in the literature. While the associated clinical features in many cases of AI are unknown, detailed examples are provided for the medical conditions, medications and exposures with clinical importance. In

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Section: Agnosis a N D M A Nage M E N Tmentioning

confidence: 99%

Section: Diagnosis and Managementmentioning

confidence: 99%

Acquired ichthyosis, asteatotic dermatitis or xerosis? An update on pathoetiology and drug‐induced associations

Park

Saeidian

Youssefian

et al. 2022

Acad Dermatol Venereol

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“…Cutaneous keratinization disorder, characterized by an accumulation of cutaneous scales resembling fish scales 139 …”

Section: Neoplastic Disordersmentioning

confidence: 99%

“…Malignancy typically precedes development of acquired ichthyosis. Severity of acquired ichthyosis correlates with the progression of the malignancy, 139 rarely occurs in setting of BC 140 …”

Section: Neoplastic Disordersmentioning

confidence: 99%

Dermatologic sequelae of breast cancer: From disease, surgery, and radiation

2020

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The care of breast cancer patients is important to dermatologists. Breast cancer’s initial presentation, clinical progression, and its associated treatments can result in a variety of cutaneous complications. Dermatologists may be the first to identify a breast cancer diagnosis, as a subset of patients first present with direct extension of an underlying tumor or with a cutaneous metastasis. The surgical treatment of breast cancer also begets a variety of skin sequelae, including postoperative lymphedema, soft tissue infections, seromas, pyoderma gangrenosum, and scarring disorders. Moreover, breast cancer radiation treatment commonly results in skin changes, which can range from mild and temporary dermatoses to chronic and disfiguring skin ulceration, fibrosis, and necrosis. Radiation may also precipitate secondary malignancies, such as angiosarcoma, as well as rarer dermatologic diseases, such as radiation‐induced morphea, lichen planus, and postirradiation pseudosclerodermatous panniculitis. Finally, breast cancer is also associated with an array of paraneoplastic phenomena, including Sweet’s syndrome and the rarer intralymphatic histiocytosis. Herein, we review the dermatological manifestations of breast cancer, including conditions associated with its presentation, progression, and treatment sequelae. Chemotherapy‐induced cutaneous side effects are beyond the scope of this review. This article provides a comprehensive review for dermatologist to be able to identify, diagnose, and manage breast cancer patients from initial presentation to treatment monitoring and subsequent follow‐up.

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“…Acquired ichthyosis can be associated with medications, malignancies, and autoimmune, infectious, neurological, nutritional, endocrine, and metabolic diseases (1,2). Histologically, acquired ichthyosis is usually characterized by compact or laminated orthohyperkeratosis, a reduced or absent granular layer, and the absence of inflammatory infiltrate in the dermis (1, 2).…”

Section: To the Editormentioning

confidence: 99%