Beware of Rhabdomyolysis After a Renal Graft

Bardai, Ghita El; Chouhani, Basmat Amal; Haddane, Widad; Kabbali, N.; Houssaïni, Tarik Sqalli

doi:10.7759/cureus.30546

Cited by 1 publication

(1 citation statement)

References 11 publications

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“…In addition, there are often serious acute risks from overdosing, especially with antibiotics [ 32 ], which are further increased without adequate parallel hydration. Also statins in high doses or by DDI-enhanced exposure, which could affect the kidney graft function in the acute and long-term survey [ 163 , 164 , 165 , 166 , 167 ], are most often observed not to be dose adjusted. Respecting the DDI with TAC and CsA, pravastatin should be preferred, although dose adjustments are required.…”

Section: Discussionmentioning

confidence: 99%

A Drug Safety Briefing (II) in Transplantation from Real-World Individual Pharmacotherapy Management to Prevent Patient and Graft from Polypharmacy Risks at the Very Earliest Stage

Wolf

2024

Pharmaceuticals

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For early and long-term patient and graft survival, drug therapy in solid organ and hematopoietic stem cell transplantation inevitably involves polypharmacy in patients with widely varying and even abruptly changing conditions. In this second part, relevant medication briefing is provided, in addition to the scores defined in the previously published first part on the design of the Individual Pharmacotherapy Management (IPM). The focus is on the growing spectrum of contemporary polypharmacy in transplant patients, including early and long-term follow-up medications. 1. Unlike the available drug–drug interaction (DDI) tables, for the first time, this methodological all-in-one device refers to the entire risks, including contraindications, special warnings, adverse drug reactions (ADRs), and DDIs. The selection of 65 common critical drugs results from 10 years of daily IPM with real-world evidence from more than 60,800 IPM inpatient and outpatient medication analyses. It includes immunosuppressants and typical critical antimicrobials, analgesics, antihypertensives, oral anticoagulants, antiarrhythmics, antilipids, antidepressants, antipsychotics, antipropulsives, antiemetics, propulsives, proton pump inhibitors (PPIs), sedatives, antineoplastics, and protein kinase inhibitors. As a guide for the attending physician, the drug-related risks are presented in an alphabetical overview based on the Summaries of Product Characteristics (SmPCs) and the literature. 2. Further briefing refers to own proven clinical measures to manage unavoidable drug-related high-risk situations. Drug-induced injuries to the vulnerable graft and the immunosuppressed comorbid patient require such standardized, intensive IPM and the comprehensive preventive briefing toolset to optimize the outcomes in the polypharmacy setting.

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Section: Discussionmentioning

confidence: 99%

A Drug Safety Briefing (II) in Transplantation from Real-World Individual Pharmacotherapy Management to Prevent Patient and Graft from Polypharmacy Risks at the Very Earliest Stage

Wolf

2024

Pharmaceuticals

View full text Add to dashboard Cite

show abstract

Beware of Rhabdomyolysis After a Renal Graft

Cited by 1 publication

References 11 publications

A Drug Safety Briefing (II) in Transplantation from Real-World Individual Pharmacotherapy Management to Prevent Patient and Graft from Polypharmacy Risks at the Very Earliest Stage

A Drug Safety Briefing (II) in Transplantation from Real-World Individual Pharmacotherapy Management to Prevent Patient and Graft from Polypharmacy Risks at the Very Earliest Stage

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