Beware of pharyngeal Fusobacterium nucleatum in COVID-19

Bao, Lirong; Zhang, Cheng; Lyu, Jinglu; Yan, Caixia; Cao, Ranran; Pan, Ming; Li, Yan

doi:10.1186/s12866-021-02336-6

Cited by 10 publications

(17 citation statements)

References 64 publications

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“…Previous studies have reported that Prevotella could drive inflammation, dampen innate immune responses [ 27 ], and contribute to oral inflammatory processes [ 28 ]. Abdul et al found that the over-expressed Prevotella proteins could promote viral infection, suggesting that Prevotella plays an important role in in the progression of COVID-19 [ 29 , 30 ]. Taken together, these findings indicated that the increase in butyrate-producing Fusobacterium and the decrease in the opportunistic pathogen Prevotella contribute to the recovery of SARS-CoV-2 infection.…”

Section: Discussionmentioning

confidence: 99%

Characterization of oral bacterial and fungal microbiome in recovered COVID-19 patients

et al. 2023

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COVID-19 has emerged as a global pandemic, challenging the world’s economic and health systems. Human oral microbiota comprises the second largest microbial community after the gut microbiota and is closely related to respiratory tract infections; however, oral microbiomes of patients who have recovered from COVID-19 have not yet been thoroughly studied. Herein, we compared the oral bacterial and fungal microbiota after clearance of SARS-CoV-2 in 23 COVID-19 recovered patients to those of 29 healthy individuals. Our results showed that both bacterial and fungal diversity were nearly normalized in recovered patients. The relative abundance of some specific bacteria and fungi, primarily opportunistic pathogens, decreased in recovered patients (RPs), while the abundance of butyrate-producing organisms increased in these patients. Moreover, these differences were still present for some organisms at 12 months after recovery, indicating the need for long-term monitoring of COVID-19 patients after virus clearance.

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Section: Discussionmentioning

confidence: 99%

Characterization of oral bacterial and fungal microbiome in recovered COVID-19 patients

et al. 2023

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“…Over the last decade, several studies, albeit focusing primarily on adults, have reported an increasing trend in anaerobic pathogen isolation; however, the leading pathogens remain aerobic in nature 28,29 . We suspect that the Fusobacterium and Streptococcus Anginosus surge apparent in our cultures stemmed from alterations in the normal oral and oropharyngeal flora, a phenomenon previously described during the pandemic 30,31 . We presume that these changes were a byproduct of pandemic‐imposed non‐pharmaceutical interventions, namely mask usage, lockdowns and social distancing.…”

Section: Discussionmentioning

confidence: 79%

Impact of the COVID‐19 era on clinical presentation, management and microbiology in paediatric peritonsillar abscess: A case–control study

Heilig,

Sapir,

Yafit

et al. 2023

Clinical Otolaryngology

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ObjectivesPeritonsillar abscess (PTA) is the most common soft‐tissue infection of the head and neck. This potential complication of tonsillitis has demonstrated unique microbial trends during the COVID‐19 pandemic. This era has resulted in a major shift in the hygiene and social habits of the general population, which has resulted in changes in the presentation, management and microbiology of several infectious diseases. To date, the impact of COVID 19 on PTA microbiology and clinical presentation in the paediatric population has yet to be investigated.DesignRetrospective chart review comparing all cases of paediatric (age 0–18) PTA in an academic tertiary centre during the COVID‐19 pandemic (03/2020–02/2022) and compared them to two control groups: pre‐COVID (03/2018–02/2020) and post‐COVID (03/2022–03/2023). All patients were treated with either needle aspiration, incision and drainage or both means in addition to intravenous antibiotics.SettingA large Ear Nose and Throat department in a tertiary referral center.ParticipantsConsecutive children aged 18 years or under, admitted with a diagnosis of Peritonsillar abscess.Main Outcome MeasuresWe analyzed the clinical and microbiologcal features of all cases of pediatric peritonsillar abscess during the COVID‐19 era (03/2020‐02/2022) and compared them to a pre and post control cases.ResultsA total of 96 PTA cases were included (35 pre‐COVID, 35 COVID and 26 post‐COVID). The means of procedural treatment shifted in favour of incision and drainage versus needle aspiration during the COVID era. The length of hospitalisation increased during the COVID era (3.6 days vs. 2.1 and 3.1 pre and post‐COVID respectively, p < .001). No other notable differences in the clinical and demographic features were found between the three eras. The COVID‐19 era saw an increase in Fusobacterium (37.1% vs. 8.6% and 24% pre and post‐COVID, respectively; p = .008) and Streptococcus Anginosus (31.4% vs. 5.7% and 7.7% pre and post‐COVID, respectively; p = .007) species isolation.ConclusionsThe COVID‐19 pandemic did not seem to impact the clinical presentation of paediatric PTA yet resulted in a change in microbiological pathogens. The choice of I&D as a means to shorten hospital stay during the pandemic may have led to an actual increase in hospital stay, suggesting that NA may be the preferred management approach.

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“…Colonization of oropharynx or lower respiratory tract led to the risk of ventilator-associated pneumonia [44]. In addition, it was significantly increased in COVID-19 patients [45]. Therefore, increased Fusobacterium nucleatum in oral microbiome may be the pathogen responsible for postoperative pneumonia at both initial visit and after preoperative oral care management.…”

Section: Discussionmentioning

confidence: 99%

Incidence of Postoperative Pneumonia and Oral Microbiome for Patients with Cancer Operation

et al. 2022

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Postoperative pneumonia is a serious problem for patients and medical staff. In Japan, many hospitals introduced perioperative oral care management for the efficient use of medical resources. However, a high percentage of postoperative pneumonia still developed. Therefore, there is a need to identify the specific respiratory pathogens to predict the incidence of pneumonia The purpose of this study was to find out the candidate of bacterial species for the postoperative pneumonia. This study applied case-control study design for the patients who had a cancer operation with or without postoperative pneumonia. A total of 10 patients undergoing a cancer operation under general anesthesia participated in this study. The day before a cancer operation, preoperative oral care management was applied. Using the next generation sequence, oral microbiome of these patients was analyzed at the time of their first visit, the day before and after a cancer operation. Porphyromonas gingivalis and Fusobacterium nucleatum group can be a high risk at first visit. Atopobium parvulum and Enterococcus faecalis before a cancer operation can be a high risk. Poor oral hygiene increased the risk of incidence of postoperative pneumonia. Increased periodontal pathogens can be a high risk of the incidence of postoperative pneumonia. In addition, increased intestinal bacteria after oral care management can also be a high risk for the incidence of postoperative pneumonia.

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Beware of pharyngeal Fusobacterium nucleatum in COVID-19

Cited by 10 publications

References 64 publications

Characterization of oral bacterial and fungal microbiome in recovered COVID-19 patients

Characterization of oral bacterial and fungal microbiome in recovered COVID-19 patients

Impact of the COVID‐19 era on clinical presentation, management and microbiology in paediatric peritonsillar abscess: A case–control study

Incidence of Postoperative Pneumonia and Oral Microbiome for Patients with Cancer Operation

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