Beware of bone pain with bisphosphonates

Mailoo, Venthan J.; Srinivas, V.; Turner, Jeremy; Fraser, William D.

doi:10.1136/bcr-2018-225385

Cited by 10 publications

(8 citation statements)

References 8 publications

(19 reference statements)

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“…6,7) However, anecdotal studies showed improvement without surgery using TPTD as anabolic therapy. 9) TPTD, a PTH(1-34) fragment, is another option for the treatment of incomplete AFFs. There is low-quality evidence that TPTD increases bone healing in patients with BP-related AFFs by enhancing bone turnover.…”

Section: Discussionmentioning

confidence: 99%

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Management Challenges in Atypical Femoral Fractures: A Case Report

Golsorkhtabaramiri

Inderjeeth

2020

Ann Geriatr Med Res

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A 78-year-old woman presented with an atypical femoral fracture of her right femur associated with a left thigh stress fracture following 9 years of bisphosphonate therapy. The fracture was managed with femoral nailing. However, she represented 3 years later with peri-prosthetic infection, worsening of the left-side stress fracture, and low bone turnover in a bone metabolic study, consistent with an ongoing bisphosphonate effect. This case highlights the increased rate of postoperative complications in atypical femoral fractures even years after surgery as well as the challenging management issues for contralateral fracture and the risk of missing bilateral fractures.

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Section: Discussionmentioning

confidence: 99%

“…6 , 7 ) However, anecdotal studies showed improvement without surgery using TPTD as anabolic therapy. 9 )…”

Section: Discussionmentioning

confidence: 99%

Management Challenges in Atypical Femoral Fractures: A Case Report

Golsorkhtabaramiri

Inderjeeth

2020

Ann Geriatr Med Res

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“…For decades, the demand for artificial joints has been growing dramatically [ 1 , 2 , 3 ], while the research and development of new artificial bone joints has attracted extensive attention [ 4 , 5 , 6 ]. However, secondary injury after implantation, which is mainly caused by postoperative infection and wear of materials [ 7 ], is a key issue.…”

Section: Introductionmentioning

confidence: 99%

Tribological and Antibacterial Properties of Polyetheretherketone Composites with Black Phosphorus Nanosheets

Sun

Zhang

et al. 2022

Polymers

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Over the past few decades, polyetheretherketone (PEEK) artificial bone joint materials faced problems of poor wear resistance and easy infection, which are not suitable for the growing demand of bone joints. The tribological behavior and wear mechanism of polyetheretherketone (PEEK)/polytetrafluoroethylene (PTFE) with black phosphorus (BP) nanosheets have been investigated under dry sliding friction. Compared with pure PEEK, the COF of PEEK/10 wt% PTFE/0.5 wt% BP was reduced by about 73% (from 0.369 to 0.097) and the wear rate decreased by approximately 95% (from 1.0 × 10−4 mm3/(N m) to 5.1 × 10−6 mm3/(N m)) owing to the lubrication of the BP transfer film. Moreover, BP can endow the PEEK composites with excellent biological wettability and antibacterial properties. The antibacterial rate of PEEK/PTFE/BP was assessed to be over 99.9%, which might help to solve the problem of PEEK implant inflammation. After comprehensive evaluation in this research, 0.5 wt% BP nanosheet-filled PEEK/PTFE material displayed the optimum lubrication and antibacterial properties, and thus could be considered as a potential candidate for its application in biomedical materials.

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“…Bone fractures are the leading cause of hospitalisations worldwide [1], with approximately 2.8 million bone repair cases performed annually [2]. The bone repair market was recorded at $53 billion globally in 2018, with the expectation of increasing to $75 billion by 2023 [3].…”

Section: Introductionmentioning

confidence: 99%