Beverages of lemon juice and exotic noni and papaya with potential for anticholinergic effects

Gironés-Vilaplana, Amadeo; Valentão, Patrı́cia; Andrade, Paula B.; Ferreres, Federico; Moreno, Diego A.; García‐Viguera, Cristina

doi:10.1016/j.foodchem.2014.08.021

Cited by 24 publications

(11 citation statements)

References 30 publications

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“…C. maxima (shaddock), C. paradisi (grapefruit), C. limon (lemon), C. sinensis (orange) and C. reticulata (tangerine) and the aqueous extracts from C. sinensis, C. paradisi and C. maxima as well as the essential oil isolated from the peels of C. aurantifolia, C. aurantium and C. bergamia were reported to exert selective AChE inhibitory activity varying from moderate to remarkable levels (18,21,22), which seems contrary to our fi ndings on selective BChE inhibition of the Citrus cultivars screened herein (Table 1). Nevertheless, C. limon was reported to have a weak cholinesterase inhibitory activity, dissimilar to most of our data on C. limon cultivars (23).…”

Section: Hptlc Profi Le Of the Extractscontrasting

confidence: 99%

“…A number of studies have demonstrated a potent cholinesterase inhibitory eff ect of various Citrus species, particularly against AChE, such as C. unshiu (12), C. paradisi (13), C. junos (14), C. medica 'Diamante' (15), C. hystrix (16), C. depressa (17), C. aurantifolia, C. aurantium and C. ber gamia (18)(19)(20), C. maxima, C. paradisi, C. limon, C. sinensis and C. reticulata (21)(22)(23). The health eff ects of Citrus fruits have been principally att ributed to the existence of phenolic compounds including fl avonoids and phenolic acids.…”

Section: Hptlc Profi Le Of the Extractsmentioning

confidence: 99%

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HPTLC Finger-Printing and Cholinesterase Inhibitory and Metal-Chelating Capacity of Various Citrus Cultivars and Olea europaea

Şenol

Ankli²,

Reich³

et al. 2016

Food Technol. Biotechnol.

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SummaryInhibitory activity of thirty-one ethanol extracts obtained from albedo, fl avedo, seed and leaf parts of 17 cultivars of Citrus species from Turkey, the bark and leaves of Olea europaea L. from two locations (Turkey and Cyprus) as well as caff eic acid and hesperidin was tested against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), related to the pathogenesis of Alzheimer's disease, using ELISA microtiter assays at 500 μg/mL. Metal-chelating capacity of the extracts was also determined. BChE inhibitory eff ect of the Citrus sp. extracts was from (7.7±0.7) to (70.3±1.1) %, whereas they did not show any inhibition against AChE. Cholinesterase inhibitory activity of the leaf and bark ethanol extracts of O. europaea was very weak ((10.2±3.1) to (15.0±2.3) %). The extracts had either no or low metal-chelating capacity at 500 μg/mL. HPTLC fi ngerprinting of the extracts, which indicated a similar phytochemical patt ern, was also done using the standards of caff eic acid and hesperidin with weak cholinesterase inhibition. Among the screened extracts, the albedo extract of C. limon 'Interdonato', the fl avedo extracts of 'Kara Limon' and 'Cyprus' cultivars and the seed extract of C. maxima appear to be promising as natural BChE inhibitors.

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Section: Hptlc Profi Le Of the Extractscontrasting

confidence: 99%

Section: Hptlc Profi Le Of the Extractsmentioning

confidence: 99%

HPTLC Finger-Printing and Cholinesterase Inhibitory and Metal-Chelating Capacity of Various Citrus Cultivars and Olea europaea

Şenol

Ankli²,

Reich³

et al. 2016

Food Technol. Biotechnol.

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“…The tropic plant Morinda citrifolia L. (Noni), also known as Indian Mulberry or Great Morinda (English), Ashyuka (Sanskrit), Ba Ji Tian (China), Cheese Fruit or Canary Wood (Australia), Hrudi (Bengali), and various other names in different countries, is a popular medicinal plant belonging to the coffee family, Rubiaceae. Noni-derived products are rich in a variety of phytochemicals and antioxidants (Potterat and Hamburger, 2007 ; Lin et al, 2012 ) and have been used in human consumption as a health promoter and a growth tonic (McClatchey, 2002 ; Chang et al, 2013 ; Lin et al, 2013 ; Gironés-Vilaplana et al, 2015 ; Nerurkar et al, 2015 ). They have been commercialized in the USA since the 1990 s and fruit juice of Noni has been approved as a Novel Food by the European Commission in 2003.…”

Section: Introductionmentioning

confidence: 99%

Noni (Morinda citrifolia) Modulates the Hypothalamic Expression of Stress- and Metabolic-Related Genes in Broilers Exposed to Acute Heat Stress

et al. 2017

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Heat stress (HS) adversely affects growth performance and inflicts heavy economic losses to the poultry industry. There is, therefore, a critical need to identify new alternative strategies to alleviate the negative effects induced by HS. The tropic medicinal plant, Morinda citrifolia (Noni), is being used in livestock nutrition, however the literature is limited and conflicting for its impact on growth performance. The present study aimed to determine the effect of Noni on feeding and drinking behavior as well as on the hypothalamic expression of stress- and metabolic-related genes in broiler chickens exposed to acute HS. A total of 480 1 day-old male broiler chicks were randomly assigned to 12 controlled environmental chambers. Birds were subjected to two environmental conditions (TN, 25°C vs. HS, 35°C for 2 h) and fed two diets (control vs. 0.2% Noni) in a 2 × 2 factorial design. Feed intake and core body temperature (BT) were recorded during HS period. Blood was collected and hypothalamic tissues were harvested for target gene and protein analyses. Acute HS-broilers exhibited higher BT (~1°C), spent less time eating with a significant decrease in feed intake, and spent more time drinking along with higher drinking frequency compared to those maintained under TN conditions. Although Noni supplementation did not improve feed intake, it significantly delayed (~30 min) and reduced the BT-induced by HS. At molecular levels and under HS conditions, Noni supplementation down regulated the hypothalamic expression of HSP90 and its related transcription factors HSF1, 2, and 4, increased orexin mRNA levels, and decreased the phosphorylation levels of AMPKα1/2Thr172 and mTORSer2481. Together, these data indicated that Noni supplementation might modulate HS response in broilers through central orexin-AMPK-mTOR pathways.

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“…The growing interest in new value-added foods and beverages with health-promoting properties has prompted the development of new beverages based on different types of water, juices and nonalcoholic drinks that are enriched in fruits, as natural sources of nutrients, colors, and bioactive phytochemicals, and the evaluation of their bioactivity is being necessary (Gironés-Vilaplana et al, 2015). Fruit juices are usually employed as food matrices for the production of functional foods.…”

Section: Introductionmentioning

confidence: 99%

A study of fortification of lemonade with herbal extracts

et al. 2016

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The aim of the present work was to design new beverages using lemonade and some herbal extracts (linden, heather, green tea, lemon verbena, clove, peppermint, ginger and mate) rich in vitamin C and flavonoids. The linden-added lemonade showed the highest value (597.9 mg/kg) for ascorbic acid content, whereas the lemon verbena-added lemonade showed the lowest value (486.04 mg/kg). The amount of saccharose was changed between 11.07-11.58%, the glucose by 1.11-1.62% and the fructose by 11.07-11.58% in the beverages. K, Na, Mg and P values in the lemonades were determined in the range of 178.83-210.98 mg/kg, 33.75-39.13 mg/kg, 22.37-27.89 mg/kg and 7.22-10.04 mg/kg, respectively. The total phenolic content in the samples changed between 315.11-397.57 mg GAE/100 g. When the samples were analyzed for antioxidant activity, FRAP (17.13-26.79 µmol trolox/mL) and ABTS (16.91-25.38 µmol trolox/mL) methods gave higher results than the DPPH (14.88-17.72 µmol trolox/mL) method. Linden-, ginger-and peppermint-added lemonades, which had been found to be rich in total phenolic compounds and ascorbic acid, showed higher antioxidant activity than the control sample. Dverall, the most preferred lemonades were heather-and ginger-added beverages and the control sample. Mate-added lemonade was the least preferred.Keywords: lemonade; beverage; herbal extract; antioxidant activity.Practical Application: Herbs are generally consumed in winter as a hot beverage. Addition of these herb extracts to lemonades allows the production of alternative cold beverages that have high nutritional value and are preferred by consumers for their sensory properties. These ready-to-drink, thirst quenching, blended lemonades will satisfy the consumer's demand for nutritious, healthy beverages and thus have good potential for commercialization.

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Beverages of lemon juice and exotic noni and papaya with potential for anticholinergic effects

Cited by 24 publications

References 30 publications

HPTLC Finger-Printing and Cholinesterase Inhibitory and Metal-Chelating Capacity of Various Citrus Cultivars and Olea europaea

HPTLC Finger-Printing and Cholinesterase Inhibitory and Metal-Chelating Capacity of Various Citrus Cultivars and Olea europaea

Noni (Morinda citrifolia) Modulates the Hypothalamic Expression of Stress- and Metabolic-Related Genes in Broilers Exposed to Acute Heat Stress

A study of fortification of lemonade with herbal extracts

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