Between evidence and commerce – the case of sufentanil sublingual tablet systems

Bantel, Carsten; Laycock, Helen

doi:10.1111/anae.14037

Cited by 5 publications

(3 citation statements)

References 57 publications

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“…The detailed preoperative explanation and communication will make patients prepared psychologically, which can improve their cooperation, effectively reduce the stress reactions generated during the perioperative period, shorten the anesthesia awakening time, and reduce the postoperative pain. Patients will also understand the anesthesia steps and postoperative recovery process in advance to reduce unnecessary excessive stress and make them emotionally stable [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Postoperative effect of sufentanil preemptive analgesia combined with psychological intervention on breast cancer patients

et al. 2023

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Objectives To explore the postoperative effects of sufentanil preemptive analgesia combined with psychological intervention on breast cancer patients undergoing radical surgery. Methods 112 female breast cancer patients aged 18–80 years old who underwent radical surgery by the same surgeon were randomly divided into 4 groups, and there were 28 patients in each group. Patients in group A were given 10 µg sufentanil preemptive analgesia combined with perioperative psychological support therapy (PPST), group B had only 10 µg sufentanil preemptive analgesia, group C had only PPST, and group D were under general anesthesia with conventional intubation. Visual analogue scoring (VAS) was used for analgesic evaluation at 2, 12 and 24 h after surgery and compared among the four groups by ANOVA method. Results The awakening time of patients in group A or B was significantly shorter than that in group C or D, and the awakening time in group C was significantly shorter than that in group D. Moreover, patients in group A had the shortest extubation time, while the group D had the longest extubation time. The VAS scores at different time points showed significant difference, and the VAS scores at 12 and 24 h were significantly lower than those at 2 h (P < 0.05). The VAS scores and the changing trend of VAS scores were varied among the four groups (P < 0.05). In addition, we also found that patients in group A had the longest time to use the first pain medication after surgery, while patients in group D had the shortest time. But the adverse reactions among the four groups showed no difference. Conclusions Sufentanil preemptive analgesia combined with psychological intervention can effectively relieve the postoperative pain of breast cancer patients.

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Section: Discussionmentioning

confidence: 99%

Postoperative effect of sufentanil preemptive analgesia combined with psychological intervention on breast cancer patients

et al. 2023

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“…The notion is further supported by reports showing pharmaceutical companies in Germany and the USA are spending considerably on advertisements 28,29. Here industry predominantly focuses on prescribing physicians through a variety of promotional strategies 30. Despite some initiatives to reduce the influence of companies, sponsoring of educational events and experts, for instance, is still common place in Germany and hence increasingly criticized 31.…”

Section: Discussionmentioning

confidence: 99%

<p>Pain And The Use Of Gabapentinoids In German Nursing Home Residents - Results From An Analysis Based On Statutory Health Insurance Data</p>

Bantel¹,

Hoffmann²,

Jobski³

2019

JPR

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BackgroundGabapentinoids (gabapentin and pregabalin) are psychoactive medications that are increasingly used for different conditions. Since there is evidence that psychotropic drugs, in general, are often inappropriately prescribed in elderly patients, we aimed to determine frequency and indications of gabapentinoid prescribing for nursing home residents.MethodsWe analyzed data from a large German statutory health insurance database. Included were records from people ≥65 years-of-age, who were admitted to a nursing home between January 2010 and December 2014. We determined the number and proportion of common indications for on- and off-label prescriptions, the most frequent co-medications, and the characteristics of patients and prescribers.ResultsOf 127,277 residents, 9539 (7.5%) received gabapentinoids and 4852 initiated treatment (4.0%; with 66.3% pregabalin). Median age of gabapentinoid initiators was 84 years (78.5% females). In these users, on-label prescribing was found in 57.4%, predominantly for neuropathic pain. Other painful conditions were also chief causes (84.7%) for off-label prescribing. Gabapentinoids were mainly started by general practitioners (64.5%) while pain specialists contributed <2%. Forty-six percent of users received additional opioids and in 27.5% gabapentinoids were prescribed only once.ConclusionGabapentinoids were frequently used in nursing home residents. Regular co-prescribing with opioids and psychotropic drugs might indicate employment to improve pain or assist treatment of conditions that are frequently associated with disruptive behavior such as dementia. However, more research is needed to better understand decision-making regarding gabapentinoid prescribing, especially in view of aggressive marketing, uncertain analgesic effects, problematic side effects, and uncritical use in the elderly.

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“…In their review of studies examining the efficacy of sublingual Sufentanil, Bantel & Laycock report that only one study compared sublingual Sufentanil (15 μg/dose; 20‐minute lockout) with an active comparator (1 mg/dose morphine; 6‐minute lockout). While this study showed that sublingual Sufentanil was not inferior (and perhaps even superior) to morphine, results should be interpreted in light of certain limitations.…”

mentioning

confidence: 99%

Response to FDA Commissioner's statement on Dsuvia approval

2019

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Between evidence and commerce – the case of sufentanil sublingual tablet systems

Cited by 5 publications

References 57 publications

Postoperative effect of sufentanil preemptive analgesia combined with psychological intervention on breast cancer patients

Postoperative effect of sufentanil preemptive analgesia combined with psychological intervention on breast cancer patients

<p>Pain And The Use Of Gabapentinoids In German Nursing Home Residents - Results From An Analysis Based On Statutory Health Insurance Data</p>

Response to FDA Commissioner's statement on Dsuvia approval

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