Betulinic acid, a major therapeutic triterpene of Celastrus orbiculatus Thunb., acts as a chemosensitizer of gemcitabine by promoting Chk1 degradation

Bifunctionalized Betulinic Acid Conjugates with C-3-Monodesmoside and C-28-Triphenylphosphonium Moieties with Increased Cancer Cell Targetability

“…Natural products are one of the most promising components and precursors of anticancer drugs with various mechanisms of action and relatively low toxicity . Terpenes have been recognized as relevant secondary metabolites, − among which betulinic acid (3β-hydroxy-lup-20(29)-en-28-oic acid, BetA) and related lupane-type pentacyclic triterpenoids have attracted a great interest in current drug discovery. − The ability of betulinic and betulonic acids to inhibit cancer cell growth was well established on different cell lines and primary cells from solid tumors. − …”