Betulin Complex in γ-Cyclodextrin Derivatives: Properties and Antineoplasic Activities in In Vitro and In Vivo Tumor Models

Şoica, Codruţa; Dehelean, Cristina; Danciu, Corina; Wang, Hai Ming; Wenz, Gerhard; Ambrus, Rita; Bojin, Florina; Anghel, Mariana

doi:10.3390/ijms131114992

Cited by 56 publications

(61 citation statements)

References 35 publications

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“…Valuable anticancer agents in the birch tree bark are pentacyclic triterpenes, mainly betulin and betulinic acid Soica et al, 2012). Extract prepared from oak has also reported to exhibit tumoricidal activity inhibiting the growth of murine leukemia cells (Goun et al, 2002).…”

Section: Treesmentioning

confidence: 99%

Estonian folk traditional experiences on natural anticancer remedies: From past to the future

Sak¹,

Jürisoo

Raal

2014

Pharmaceutical Biology

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Context: Despite diagnostic and therapeutic advancements, the burden of cancer is still increasing worldwide. Toxicity of current chemotherapeutics to normal cells and their resistance to tumor cells highlights the urgent need for new drugs with minimal adverse side effects. The use of natural anticancer agents has entered into the area of cancer research and increased efforts are being made to isolate bioactive products from medicinal plants. Objective: To lead the search for plants with potential cytotoxic activity, ethnopharmacological knowledge can give a great contribution. Therefore, the attention of this review is devoted to the natural remedies traditionally used for the cancer treatment by Estonian people over a period of almost 150 years. Methods: Two massive databases, the first one stored in the Estonian Folklore Archives and the second one in the electronic database HERBA (http://herba.folklore.ee/), containing altogether more than 30 000 ethnomedicinal texts were systematically reviewed to compile data about the Estonian folk traditional experiences on natural anticancer remedies.

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Section: Treesmentioning

confidence: 99%

Estonian folk traditional experiences on natural anticancer remedies: From past to the future

Sak¹,

Jürisoo

Raal

2014

Pharmaceutical Biology

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“…antibacterial, antiviral, anti-parasite BE: [5,6]; BA: [7][8][9]; BE/BA: [10,11]; BE/BA/OA: [12]; LU/BA: [13]; OA/BA: [14] hepatoprotective BE: [15]; BE/BA: [16]; OA: [17][18][19][20]; LU: [21]; BA: [22] antitumor BE: [23,24]; BA: [25,26] BE/BA: [27,28]; LU: [29]; OA: [18,19,30] wound healing extract: [31][32][33]; BA: [34]; OA: [35,36] anti-inflammatory BE: [5,37]; LU: [38,39]; OA: [18,40] Apart from these pharmacological effects, birch bark extract is able to act as a gelling agent and Pickering emulsifier [41][42][43]. Together with its anti-inflammatory and wound healing effects, this makes birch bark dry extract interesting for the stabilisation of semisolid systems, such as gels and creams, acting as an active ingredient and an excipient in parallel.…”

Section: Pharmacological Effects Of Triterpenoids Contained In Birchmentioning

confidence: 99%

Birch Bark Dry Extract by Supercritical Fluid Technology: Extract Characterisation and Use for Stabilisation of Semisolid Systems

Armbruster

Mönckedieck²,

Scherließ³

et al. 2017

Applied Sciences

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Abstract:Triterpene compounds like betulin, betulinic acid, erythrodiol, oleanolic acid and lupeol are known for many pharmacological effects. All these substances are found in the outer bark of birch. Apart from its pharmacological effects, birch bark extract can be used to stabilise semisolid systems. Normally, birch bark extract is produced for this purpose by extraction with organic solvents. Employing supercritical fluid technology, our aim was to develop a birch bark dry extract suitable for stabilisation of lipophilic gels with improved properties while avoiding the use of toxic solvents. With supercritical carbon dioxide, three different particle formation methods from supercritical solutions have been tested. First, particle deposition was performed from a supercritical solution in an expansion chamber. Second, the Rapid Expansion of Supercritical Solutions (RESS) method was used for particle generation. Third, a modified RESS-procedure, forming the particles directly into the thereby gelated liquid, was developed. All three methods gave yields from 1% to 5.8%, depending on the techniques employed. The triterpene composition of the three extracts was comparable: all three gave more stable oleogels compared to the use of an extract obtained by organic solvent extraction. Characterizing the rheological behaviour of these gels, a faster gelling effect was seen together with a lower concentration of the extract required for the gel formation with the supercritical fluid (SCF)-extracts. This confirms the superiority of the supercritical fluid produced extracts with regard to the oleogel forming properties.

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“…; Şoica et al . ). The erythema and tumour growth measurements show that both parameters increased linearly after cell inoculation.…”

Section: Discussionmentioning

confidence: 97%

Behaviour of four different B16 murine melanoma cell sublines: C57BL/6J skin

Danciu

Oprean

Coricovac

et al. 2015

Int J Experimental Path

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Transplantable murine melanomas are well-established models for the study of experimental cancer therapies. The aim of this study was to explore the behaviour of four different B16 murine melanoma cell sublines after inoculation into C57BL/6J mice; and, more specifically to analyse skin changes, with respect to two specific parameters: clinical (tumour volume, melanin amount, erythema) and histological (H & E, S100, VEGF expression). Both non-invasive and invasive analysis showed that B164A5 is the most aggressive melanoma cell line for C57BL/6J's skin, followed by B16F10 and then by diminished aggressive growth pattern by the B16GMCSF and B16FLT3 cell lines.

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Betulin Complex in γ-Cyclodextrin Derivatives: Properties and Antineoplasic Activities in In Vitro and In Vivo Tumor Models

Cited by 56 publications

References 35 publications

Estonian folk traditional experiences on natural anticancer remedies: From past to the future

Estonian folk traditional experiences on natural anticancer remedies: From past to the future

Birch Bark Dry Extract by Supercritical Fluid Technology: Extract Characterisation and Use for Stabilisation of Semisolid Systems

Behaviour of four different B16 murine melanoma cell sublines: C57BL/6J skin

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