Better Sleep at Night: How Light Influences Sleep in Drosophila

Mazzotta, Gabriella; Damulewicz, Milena; Cusumano, Paola

doi:10.3389/fphys.2020.00997

Cited by 13 publications

(6 citation statements)

References 262 publications

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“…Biogenic amines are also involved in controlling many behavioral aspects, such as olfactory learning, courtship, locomotor activity, and sleep. Sleep is essential for the development and survival of organisms, and its regulation by environmental factors such as temperature ( Fan et al, 2022 ) and light ( Mazzotta et al, 2020 ) is well documented in Drosophila . Neurotransmitters play a key role in regulating Drosophila sleep, with serotonin playing a sleep-promoting function opposite to the wake-promoting activity of dopamine ( Ly et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of aminergic signaling on the humoral innate immunity response of Drosophila

Cattabriga,

Giordani,

Gargiulo

et al. 2023

Front. Physiol.

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Biogenic amines are crucial signaling molecules that modulate various physiological life functions both in vertebrates and invertebrates. In humans, these neurotransmitters influence the innate and adaptive immunity systems. In this work, we analyzed whether the aminergic neurotransmission of dopamine, serotonin, and octopamine could have an impact on the humoral innate immune response of Drosophila melanogaster. This is a powerful model system widely used to uncover the insect innate immunity mechanisms which are also conserved in mammals. We found that the neurotransmission of all these amines positively modulates the Toll-responsive antimicrobial peptide (AMP) drosomycin (drs) gene in adult flies infected with the Micrococcus luteus bacterium. Indeed, we showed that either blocking the neurotransmission in their specific aminergic neurons by expressing shibirets (Shits) or silencing the vesicular monoamine transporter gene (dVMAT) by RNAi caused a significantly reduced expression of the Toll-responsive drs gene. However, upon M. luteus infection, the block of aminergic transmission did not alter the expression of AMP attacin genes responding to the immune deficiency (Imd) and Toll pathways. Overall, our results not only reveal a neuroimmune function for biogenic amines in humoral immunity but also further highlight the complexity of the network controlling AMP gene regulation.

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Section: Discussionmentioning

confidence: 99%

Effect of aminergic signaling on the humoral innate immunity response of Drosophila

Cattabriga,

Giordani,

Gargiulo

et al. 2023

Front. Physiol.

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“…Flies exhibit a similar correlation between BTR and sleep induction; they decrease their Tp dramatically before starting nighttime sleep (the night-onset TPR). Given that the neural activity of DN1ps is critical for both TPR and sleep, DN1ps might be important hubs between TPR and sleep ( Guo et al, 2016 ; Dubowy and Sehgal, 2017 ; Lamaze and Stanewsky, 2019 ; Mazzotta et al, 2020 ; Shafer and Keene, 2021 ; Chen et al, 2022 ). DN1ps express DH31, which regulates the night-onset TPR ( Goda et al, 2016 , 2018 ) and arousal before dawn ( Kunst et al, 2014 ; Goda et al, 2019 ; Goda and Hamada, 2019 ).…”

Section: Tpr Might Be Associated With Sleepmentioning

confidence: 99%

Molecular and Neural Mechanisms of Temperature Preference Rhythm in Drosophila melanogaster

2023

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Temperature influences animal physiology and behavior. Animals must set an appropriate body temperature to maintain homeostasis and maximize survival. Mammals set their body temperatures using metabolic and behavioral strategies. The daily fluctuation in body temperature is called the body temperature rhythm (BTR). For example, human body temperature increases during wakefulness and decreases during sleep. BTR is controlled by the circadian clock, is closely linked with metabolism and sleep, and entrains peripheral clocks located in the liver and lungs. However, the underlying mechanisms of BTR are largely unclear. In contrast to mammals, small ectotherms, such as Drosophila, control their body temperatures by choosing appropriate environmental temperatures. The preferred temperature of Drosophila increases during the day and decreases at night; this pattern is referred to as the temperature preference rhythm (TPR). As flies are small ectotherms, their body temperature is close to that of the surrounding environment. Thus, Drosophila TPR produces BTR, which exhibits a pattern similar to that of human BTR. In this review, we summarize the regulatory mechanisms of TPR, including recent studies that describe neuronal circuits relaying ambient temperature information to dorsal neurons (DNs). The neuropeptide diuretic hormone 31 (DH31) and its receptor (DH31R) regulate TPR, and a mammalian homolog of DH31R, the calcitonin receptor (CALCR), also plays an important role in mouse BTR regulation. In addition, both fly TPR and mammalian BTR are separately regulated from another clock output, locomotor activity rhythms. These findings suggest that the fundamental mechanisms of BTR regulation may be conserved between mammals and flies. Furthermore, we discuss the relationships between TPR and other physiological functions, such as sleep. The dissection of the regulatory mechanisms of Drosophila TPR could facilitate an understanding of mammalian BTR and the interaction between BTR and sleep regulation.

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“…Indeed, cooperative input from CRY and the visual system allow fine tuning of evening anticipation under different photoperiods ( Kistenpfennig et al, 2018 ). The l-LNvs are the target neuronal clusters within the CNN for many arousal promoting neurotransmitters ( Mazzotta et al, 2020 ). The HB-eyelet, a light-sensing body in the retina, and photoreceptors from the eye form synaptic connections with the LNvs, which contributes to morning arousal ( Damulewicz et al, 2020 ; Helfrich-Förster et al, 2002 ; Hofbauer and Buchner, 1989 ; Veleri et al, 2007 ).…”

Section: Neurotransmission In the Circadian Neuronal Networkmentioning

confidence: 99%

Integration of Circadian Clock Information in the Drosophila Circadian Neuronal Network

Ahmad

Top

2021

J Biol Rhythms

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Circadian clocks are biochemical time-keeping machines that synchronize animal behavior and physiology with planetary rhythms. In Drosophila, the core components of the clock comprise a transcription/translation feedback loop and are expressed in seven neuronal clusters in the brain. Although it is increasingly evident that the clocks in each of the neuronal clusters are regulated differently, how these clocks communicate with each other across the circadian neuronal network is less clear. Here, we review the latest evidence that describes the physical connectivity of the circadian neuronal network . Using small ventral lateral neurons as a starting point, we summarize how one clock may communicate with another, highlighting the signaling pathways that are both upstream and downstream of these clocks. We propose that additional efforts are required to understand how temporal information generated in each circadian neuron is integrated across a neuronal circuit to regulate rhythmic behavior.

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Better Sleep at Night: How Light Influences Sleep in Drosophila

Cited by 13 publications

References 262 publications

Effect of aminergic signaling on the humoral innate immunity response of Drosophila

Effect of aminergic signaling on the humoral innate immunity response of Drosophila

Molecular and Neural Mechanisms of Temperature Preference Rhythm in Drosophila melanogaster

Integration of Circadian Clock Information in the Drosophila Circadian Neuronal Network

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