Better quality of life with neuropsychological improvement on HAART

Parsons, Thomas D.; Braaten, Alyssa; Hall, Colin D.; Robertson, Kevin

doi:10.1186/1477-7525-4-11

Cited by 59 publications

(34 citation statements)

References 33 publications

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“…Among the 12 included studies, ten showed a positive correlation between adherence and QoL, with a concomitant increase in treatment adherence and QoL. 1,4,7,12,13,16,17,23,24,26 In the three prospective cohort studies, 7,13,27 the success of treatment adherence over time was associated with greater QoL. In the cross-sectional studies, 1,12,17,23,24,26 it was also possible to observe positive correlations between QoL and adherence.…”

Section: Resultsmentioning

confidence: 98%

“…Despite the positive correlations in the studies, some factors should be considered, such as the use of nonrandomized convenience samples, 1,7,12,16,17,23 sampling of only male patients 23 and utilization of QoL instruments not specifi c to HIV/AIDS patients. 4,12,13,16,26 The relationship between treatment adherence and QoL should be more thoroughly explored. Ideally, these two aspects should occur simultaneously, with adherence improving treatment outcomes.…”

Section: Discussionmentioning

confidence: 99%

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Qualidade de vida e adesão ao tratamento anti-retroviral de pacientes portadores de HIV

et al. 2010

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A review on adherence to highly active antiretroviral therapy and the quality of life of patients living with HIV in the scientifi c literature, indexed in MEDLINE between 1998 and 2008, was performed. Studies published in Portuguese, Spanish or English with patients over 18 years of age were included. Reviews, case reports and letters were excluded. Of the 21 studies found, 12 were included (three clinical trials, three prospective cohorts and six cross-sectional studies). The relationship between quality of life and treatment adherence remains controversial, despite descriptive studies indicating the possibility of a positive association. The results may have been infl uenced by the specifi c characteristics of the described clinical trials and do not show a consensus regarding the impact of treatment adherence on patients' quality of life.

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Section: Resultsmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Qualidade de vida e adesão ao tratamento anti-retroviral de pacientes portadores de HIV

et al. 2010

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“…The cART regimen aims towards controlling systemic viremia and inflammation (Gendelman et al , 1998), improving immunological function, and preventing extensive CNS inflammation (Spudich et al , 2011), resulting in increased in life expectancy and decreased HIV-related neurological complications (Parsons et al , 2006). Although cART does not completely eradicate viral-induced neurologic dysfunction, it has proven considerably effective in ameliorating further CNS progression by preventing neuronal death and decreasing CNS viral titers (Gendelman et al , 1998; Xia et al , 2011).…”

Section: Introductionmentioning

confidence: 99%

Glutamate metabolism and HIV-associated neurocognitive disorders

et al. 2014

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HIV-1 infection can lead to neurocognitive impairment collectively known as HIV-Associated Neurocognitive Disorders (HAND). Although combined antiretroviral treatment (cART) has significantly ameliorated HIV’s morbidity and mortality, persistent neuroinflammation and neurocognitive dysfunction continue. This review focuses on the current clinical and molecular evidence of the viral and host factors that influence glutamate-mediated neurotoxicity and neuropathogenesis as an important underlying mechanism during the course of HAND development. In addition, discusses potential pharmacological strategies targeting the glutamatergic system that may help prevent and improve neurological outcomes in HIV-1 infected subjects.

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“…Antiretroviral therapy (ART) extends the lives of persons living with HIV and AIDS and improves the quality of their lives [1,2]. The rapid increase in ART coverage in low- and middle-income countries, especially in Sub-Saharan Africa, has also led to a clear decline in premature mortality [3,4].…”

Section: Introductionmentioning

confidence: 99%

Monitoring prevention or emergence of HIV drug resistance: results of a population-based foundational survey of early warning indicators in mainland Tanzania

et al. 2014

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BackgroundIn Tanzania, routine individual-level testing for HIV drug resistance (HIVDR) using laboratory genotyping and phenotyping is not feasible due to resource constraints. To monitor the prevention or emergence of HIVDR at a population level, WHO developed generic strategies to be adapted by countries, which include a set of early warning indicators (EWIs).MethodsTo establish a baseline of EWIs, we conducted a retrospective longitudinal survey of 35 purposively sampled care and treatment clinics in 17 regions of mainland Tanzania. We extracted data relevant for four EWIs (ART prescribing practices, patients lost to follow-up 12 months after ART initiation, retention on first-line ART at 12 months, and ART clinic appointment keeping in the first 12 months) from the patient monitoring system on patients who initiated ART at each respective facility in 2010. We uploaded patient information into WHO HIVResNet excel-based tool to compute national and facility averages of the EWIs and tested for associations between various programmatic factors and EWI performance using Fisher’s Exact Test.ResultsAll sampled facilities met the WHO EWI target (100%) for ART prescribing practices. However, the national averages for patients lost to follow-up 12 months after ART initiation, retention on first-line ART at 12 months, and ART clinic appointment keeping in the first 12 months fell short, at 26%, 54% and 38%, respectively, compared to the WHO targets ≤ 20%, ≥ 70%, and ≥ 80%. Clinics with fewer patients lost to follow-up 12 months after ART initiation and more patients retained on first-line-ART at 12 months were more likely to have their patients spend the longest time in the facility (including wait-time and time with providers), (p = 0.011 and 0.007, respectively).ConclusionTanzania performed very well in EWI 1a, ART prescribing practices. However, its performance in other three EWIs was far below the WHO targets. This study provides a baseline for future monitoring of EWIs in Tanzania and highlights areas for improvement in the management of ART patients in order not only to prevent emergence of HIVDR due to programmatic factors, but also to improve the quality of life for ART patients.

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Better quality of life with neuropsychological improvement on HAART

Cited by 59 publications

References 33 publications

Qualidade de vida e adesão ao tratamento anti-retroviral de pacientes portadores de HIV

Qualidade de vida e adesão ao tratamento anti-retroviral de pacientes portadores de HIV

Glutamate metabolism and HIV-associated neurocognitive disorders

Monitoring prevention or emergence of HIV drug resistance: results of a population-based foundational survey of early warning indicators in mainland Tanzania

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