Better neuroprotective profile of caffeic acid phenyl ester over resveratrol in non-traumatic ischemia-reperfusion injury of the spinal cord

Aslan, Esra; Boyacı, Mehmet Gazi; Güzel, Hilal; Pektaş, Mehmet Bilgehan

doi:10.1080/02688697.2021.1999391

Cited by 1 publication

(2 citation statements)

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“…In a similar study, it was shown that infiltration of the chick embryo increased with Perm injection and tissue development decreased (Curtis et al, 2021). However, Res is known to be a powerful antioxidant and tissue-protector (Aslan et al, 2021;Bohara et al, 2022). In this context, it can be said that the effects of Perm and Res are compatible with the literature.…”

Section: Discussionsupporting

confidence: 54%

“…From this point of view, this may be the reason for Perm-dependent congestion and parenchymal damage in our study. However, the free radical scavenging activity of Res, whose hepatoprotective activity has been shown in many studies (Pektas et al, 2017;Aslan et al, 2021), may have suppressed Permdependent variables. In another similar study, the effects of Perm on the kidney were examined histopathologically, and it was shown that Perm causes necrotic and degenerative changes in the tubule epithelium and also increases apoptotic cell death (Guvenc et al, 2013).…”

Section: Discussionmentioning

confidence: 98%

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Protective effects of resveratrol on permethrin-induced fetotoxicity in rats

YÜKSEL¹,

ASLAN

Tosun

et al. 2023

Anatolian Journal of Botany

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Synthetic pyrethroid insecticides have been widely used for years to be protected from the harmful effects of insects and control disease vectors. In this study, the potential effects of resveratrol, a polyphenolic compound, against the potential toxicity of permethrin, an effective pyrethroid derivative, on the fetus were investigated. In the study, Wistar female rats were divided into four groups Control, Sham, Permethrin, and Permethrin + Resveratrol. The lung, liver, kidney, and small intestine development of fetuses were evaluated histopathologically. Also, Bone Morphogenetic Protein 4 (BMP-4) in bone tissue development and Fibroblast Growth Factor-1 (FGF-1) expressions in the lung were examined immunohistochemically. All structures in the control and sham groups were normal. Permethrin caused epithelial damage, regression in bronchial and primitive alveolar development in the lung; congestion, edema, and sinusoidal dilatation around the central vein in the liver; tubular epithelial degeneration, regression in glomeruli and tubule formation in the kidney; epithelial degeneration and irregularity in the villus structure in the small intestine. Immunohistochemical results indicated that permethrin administration decreased BMP-4 levels in bone tissue and FGF-1 levels in the lung. After resveratrol application was found to greatly alleviate histopathological and immunohistopathological variability in all tissues. Oral consumption of permethrin by pregnant rats caused growth retardation and tissue damage in many different tissues in offspring. Intake of resveratrol during pregnancy showed protective effects against fetotoxicity caused by permethrin.

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Section: Discussionsupporting

confidence: 54%