Bethesda 2001

Chhieng, David C.; Roberson, Janie; Gidley, Jonathan; Eltoum, Isam

doi:10.1159/000326385

Cited by 13 publications

(1 citation statement)

References 12 publications

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“…[2] The significance as well as consequence of cervical cytology with atypia or dyskaryosis has been extensively studied. [34] According to the 2001 Bethesda System[5] for reporting cervical cytological diagnoses, epithelial cell abnormalities originate in the squamous or glandular cells. The category of atypical squamous cells (ASC) includes ASC-US (ASC of undetermined significance) and ASC-H (ASC, cannot exclude high grade squamous intraepithelial lesions).…”

Section: Introductionmentioning

confidence: 99%

Pattern of epithelial cell abnormality in Pap smear: A clinicopathological and demographic correlation

et al. 2011

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Background:In the low resource settings of a developing country, a conventional Papanicolaou (Pap) test is the mainstay screening system for cervical cancer. In order to counsel women and to organize a public health system for cervical cancer screening by Pap smear examination, it is imperative to know the pattern of premalignant and malignant lesions. This study was undertaken to find out the prevalence of an abnormal Pap smear, in a tertiary hospital of a developing country, and to carry out a clinicopathological and demographical analysis for establishing the pattern of epithelial cell abnormality in a Pap smear.Materials and Methods:A cross-sectional descriptive study was carried out in a total of 1699 patients who underwent Pap smear examination. The prevalence of epithelial cell abnormality in the Pap smear was calculated in proportions / percentages. Specimen adequacy and reporting was assessed according to the revised Bethesda system.Results:Among the total of 1699 patients who had their Pap smear done, 139 (8.18%) revealed epithelial cell abnormality. Altogether 26 smears revealed high-grade lesions and malignancy, most of which were found to be in women belonging to the 30 – 39 and ≥ 45 age group. A total of 75 (53.96%) women were in the 20 – 44 age group and 64 (46.04%) were in the ≥ 45 age group. A bimodal age distribution was detected in the epithelial cell abnormality, with the bulk being diagnosed in patients aged 45 or above. Overall one-third of the patients with an abnormal Pap smear result showed healthy cervix in per vaginal examination.Conclusions:A raised prevalence of epithelial cell abnormality reflects the lack of awareness about cervical cancer screening. Women aged 45 or above harbor the bulk of premalignant and malignant lesions in the Pap smear, signifying that these women are among the under users of cytological screening.

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Section: Introductionmentioning

confidence: 99%

Pattern of epithelial cell abnormality in Pap smear: A clinicopathological and demographic correlation

et al. 2011

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Incidence and clinical significance of morphologically benign-appearing endometrial cells in patients age 40 years or older

Bean

Connolly

Roberson

et al. 2005

Cancer

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Objectives: This multi‐centre study reports safety and efficacy of percutaneous patent foramen ovale (PFO) closure, using the fourth generation Intrasept™ device. Background: PFO has been associated with paradoxical embolism and cryptogenic stroke. Percutaneous PFO closure seems to reduce the risk for recurrent paradoxical thrombo‐embolism. Currently, different devices are used for PFO closure. Methods: Patients, who underwent a PFO closure with the Intrasept device (Cardia, Eagan, MN) between July 2002 and September 2006, were included in the study. The primary endpoint was defined as reoccurrence of stroke, transient ischemic attack (TIA), or peripheral thrombo‐embolism. Peri‐procedural and mid‐term complications were reported. Results: Four‐hundred thirty patients (mean age 50.7 ± 13.0 years, 231 men) underwent closure. The indications were cryptogenic stroke (69.8%), TIA (23.5%), peripheral embolism (3.3%), and other (3.5%). The median follow‐up time was 0.8 years, range 3.9 years. The primary endpoint occurred in 0.5% for stroke, in 2.5% for TIA, and in none for peripheral embolism. Peri‐procedural complications were reported in 11.5% of cases, from which 0.2% was defined as major. No severe complications occurred during mid‐term follow‐up. A residual shunt was present in 12.5% of patients who did not suffer from a recurrent event, compared to 36.4% of patients who reached the primary endpoint (P = 0.04). Conclusion: This multi‐centre study suggests that percutaneous closure of a symptomatic PFO with the fourth generation Intrasept device is safe and might be effective to prevent the recurrence of paradoxical thrombo‐embolic events. © 2008 Wiley‐Liss, Inc.

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Applicability of the Bethesda System 2001 to a public health setting

Prandi

Beccati

Aloysio

et al. 2006

Cancer

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BACKGROUND The degree of applicability of the Bethesda System 2001 (TBS 2001) for cervicovaginal cytology to a public health setting is unknown, and extrapolations from available data are unwarranted. METHODS A “before/after” study design was used to evaluate the impact of TBS 2001 on an organized, population‐based screening program in northern Italy. Between 2003–2004, 6 cytology laboratories converted from TBS 1991 to TBS 2001. A set of screening indicators based on TBS 2001 (85,012 patients) were compared with those based on TBS 1991 (199,833 patients) by means of their laboratory‐ and patient age‐standardized ratio with a 95% confidence interval (CI). RESULTS The prevalence of cervical intraepithelial neoplasm (CIN)2‐3/carcinoma was stable between the 2 populations. TBS 2001 had no effect on the unsatisfactory rate (1.99% vs. 2.03% for TBS 1991) nor on follow‐up compliance rate (93.2% vs. 92.3%). The reporting rate of atypical squamous cells (ASC) decreased from 17.1 to 14.7 per 1000 (ratio, 0.86; 95% CI, 0.81–0.91), the total positivity rate from 31.1 to 29.0 per 1000 (ratio, 0.93; 95% CI, 0.90–0.97), and the ASC:SIL (squamous intraepithelial lesion) ratio from 1.38 to 1.16. Compared with the ASCUS (ASC of undetermined significance) reports of TBS 1991, the predictive value for CIN2‐3/carcinoma decreased from 5.2 to 3.5% (ratio, 0.68; 95% CI, 0.48–0.93) among ASCUS reports, but increased from 5.1 to 17.2% (ratio, 3.41; 95% CI, 1.64–6.28) among ASC‐cannot exclude high grade lesion (ASC‐H) reports. ASC‐H had a 5.01‐fold (95% CI, 2.23–10.2) greater predictive value than ASCUS. CONCLUSIONS TBS 2001 is applicable to cervical screening in a public health setting. Cancer (Cancer Cytopathol) 2006;. © 2006 American Cancer Society.

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Bethesda 2001

Cited by 13 publications

References 12 publications

Pattern of epithelial cell abnormality in Pap smear: A clinicopathological and demographic correlation

Pattern of epithelial cell abnormality in Pap smear: A clinicopathological and demographic correlation

Incidence and clinical significance of morphologically benign-appearing endometrial cells in patients age 40 years or older

Applicability of the Bethesda System 2001 to a public health setting

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