Betel quid chewing elevates human exposure to arsenic, cadmium and lead

Al-Rmalli, Shaban W.; Jenkins, Richard O.; Haris, Parvez I.

doi:10.1016/j.jhazmat.2011.02.068

Cited by 55 publications

(46 citation statements)

References 27 publications

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“…1, while that for fish samples are presented in Table 2. Our data for betel quids have been derived from our previously published work [8]. The content of As and Se in aromatic rice is also taken from one of our recent publications [9].…”

Section: Resultsmentioning

confidence: 99%

“…* When six betel quids (non-food item) are included in the estimations. A previous study reported an average daily consumption of six betel quids by Bangladeshis [8].…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, the total intake of As was determined based on As content of the largest number and the most diverse range of foods ever considered for a Bangladeshi population. Betel quid, as a non-food item, is widely consumed in Bangladesh [8] and therefore its contribution in the dietary intake of As and Se was included in the current study. The consumption of baked clay is much less widespread and therefore it has not been included in the estimations.…”

Section: Discussionmentioning

confidence: 99%

“…The concentration of As in Piper betel leaves have been determined by Al-Rmalli et al [6], and in areca nut by Signes-Pastor et al [90]. In our previous study, As and Se in both betel quids [8] and baked clay [7] were comprehensively investigated. In the current paper, we provide the most detailed estimation of the total daily intake (TDI) of As and Se in the Bangladeshi population thus far investigated.…”

Section: Introductionmentioning

confidence: 89%

“…Betel quid is widely consumed in Bangladesh and India [6,8]. Piper betel leaves and areca nut are the main components in a betel quid.…”

Section: Introductionmentioning

confidence: 99%

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Intake of arsenic and selenium in a Bangladeshi population investigated using inductively coupled plasma mass spectrometry

Al-Rmalli

Jenkins

Haris

2017

BSI

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Abstract. Millions of people in Bangladesh are exposed to high concentration of the toxic element arsenic (As) through drinking water and consumption of foods. It has also been reported that Bangladeshis have a low intake of the essential element selenium (Se), which is known to be important as an antioxidant and has been suggested to counteract the toxicity of As. We report here on total intake of As and Se in a Bangladeshi population, based on inductively coupled plasma mass spectrometric (ICP-MS) analysis of a range of Bangladeshi foods. The total daily intake of As and Se from foods was estimated to be 74.2 and 87.7 µg/day, respectively. If As from water, used for drinking and cooking rice, is included the TDI increases to 385 µg of total As per day. An important finding of our study, contrary to suggestions given in other reports, is that the Bangladeshi diet does not appear to be deficient in Se and this may explain why the blood Se concentrations in Bangladeshis is similar to the USA population. This requires further investigation and detailed dietary and human biomonitoring studies on the Bangladeshi population should be conducted. Rice and fish were the main sources of dietary As and Se for Bangladeshis. Leafy vegetables could also be a significant contributor of high concentration of As in the Bangladeshi diet. The flesh and eggs of Hilsha (Tenualosa ilisha) species of fish were found to contain particularly high levels of total arsenic (range 0.77-6.15 mg/kg) although this is likely to be dominated by the non-toxic organoarsenic species.

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Section: Resultsmentioning

confidence: 99%

“…* When six betel quids (non-food item) are included in the estimations. A previous study reported an average daily consumption of six betel quids by Bangladeshis [8].…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 89%

“…Betel quid is widely consumed in Bangladesh and India [6,8]. Piper betel leaves and areca nut are the main components in a betel quid.…”

Section: Introductionmentioning

confidence: 99%

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Intake of arsenic and selenium in a Bangladeshi population investigated using inductively coupled plasma mass spectrometry

Al-Rmalli

Jenkins

Haris

2017

BSI

Self Cite

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Systematic review of areca (betel nut) use and adverse pregnancy outcomes

Silva

Panisi

Brownfoot

et al. 2019

Intl J Gynecology & Obste

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Background Betel nut is the fourth most commonly abused substance worldwide and has been associated with significant adverse health outcomes. Little is known about its effects on the fetus. Objective To perform a systematic review of studies investigating prenatal betel nut use and adverse perinatal outcomes. Search strategy Pubmed, Embase, and Cochrane databases were searched from inception until July 2018 using the terms areca, betel nut, pregnancy, pregnancy complications, and infection. Selection criteria Eligible studies included case–control, cohort, and randomized control studies involving pregnant women. Data collection and analysis Where appropriate, bivariate meta‐analysis was performed, and odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Main results In total, 28 studies were screened and eight studies (including 15 270 women) were included in the review and meta‐analysis. Preterm birth, low birthweight, and anemia were most commonly investigated. Meta‐analysis revealed a significant association between betel nut use and low birthweight, with a pooled OR of 1.75 (95% CI, 1.35–2.27). Conclusions The review identified only eight eligible studies, all based in the Asia–Pacific region. There was a significant association between low birthweight and betel nut exposure in pregnancy. Further prospective studies are needed to confirm this association.

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Preconcentration and determination of lead and cadmium levels in blood samples of adolescent workers consuming smokeless tobacco products in Pakistan

Arain

Kazi

Afridi

et al. 2015

Environ Monit Assess

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The present study was aimed to evaluate the cadmium (Cd) and lead (Pb) levels in the blood samples of adolescent boys, chewing different smokeless tobacco (SLT) products in Pakistan. For comparative purpose, boys of the same age group (12-15 years), not consumed any SLT products were selected as referents. To determine trace levels of Cd and Pb in blood samples, a preconcentration method, vortex-assisted liquid-liquid microextraction (VLLME) has been developed, prior to analysis by flame atomic absorption spectrometry. The hydrophobic chelates of Cd and Pb with ammonium pyrrolidinedithiocarbamate were extracted into the fine droplets of ionic liquid (IL) 1-butyl-3-methylimidazolium hexafluorophosphate, while nonionic surfactant, Triton X-114 was used as a dispersing medium. The main factors affecting the recoveries of Cd and Pb, such as concentration of APDC, centrifugation time, volume of IL and TX-114, were investigated in detail. It was also observed that adolescent boys who consumed different SLT products have 2- to 3-fold higher levels of Cd and Pb in their blood samples as compared to referent boys (p < 0.001).

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Betel quid chewing elevates human exposure to arsenic, cadmium and lead

Cited by 55 publications

References 27 publications

Intake of arsenic and selenium in a Bangladeshi population investigated using inductively coupled plasma mass spectrometry

Intake of arsenic and selenium in a Bangladeshi population investigated using inductively coupled plasma mass spectrometry

Systematic review of areca (betel nut) use and adverse pregnancy outcomes

Preconcentration and determination of lead and cadmium levels in blood samples of adolescent workers consuming smokeless tobacco products in Pakistan

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