Betanin prohibits cisplatin-induced nephrotoxicity through targeting mitochondria

Abstract

Cisplatin is a common chemotherapeutic agent against a wide range of solid tumors. The clinical application of cisplatin is restricted due to its adverse effect, mainly nephrotoxicity. The aim of this study was to examine whether betanin (a natural pigment) is able to alleviate cisplatin-induced renal injury. Rats received cisplatin (10 mg/kg, single dose) after 3 consecutive days of betanin (100 mg/kg) oral gavage. Serum and urine samples were collected and kidney mitochondria were isolated from the treated groups for the further evaluations. Cisplatin-treated animals revealed altered biochemical evidence of nephrotoxicity, which were significantly improved in betanin pre-treated groups. On the other hand, betanin modulated mitochondrial parameters such as mitochondrial dehydrogenase activity, mitochondrial swelling, mitochondrial ATP content, mitochondrial depolarization, lipid peroxidation, and cytochrome c release. These data propose the possible protective role of betanin in cisplatin-associated nephrotoxicity in which the mechanism appears to be a prohibition of chemical disturbances and mitochondrial damage.

Betanin: a promising molecule for biomedical applications

“…Ardalan and coworkers have depicted that capability of betanin pretreatment to confer moderate protection against cisplatin-induced kidney injury in rats. They were able to show that betanin treatment prohibited mitochondrial lipid peroxidation, banned the induced ameliorations in dehydrogenase activity, and enhanced mitochondrial indices functionality [63].…”

“…Several research articles have dealt with the possible antifibrotic actions of betanin [63,67]. In a cardiac fibrosis model induced by a high fructose diet in Wistar rats, Han and colleagues were able to show that oral administration of betanin in doses of 25 and 100 mg/Kg/day for sixty days was able to ban the observed cardiomyopathic changes in response to high fructose diet.…”

Comparing the Efficacy of Carvedilol and Celecoxib to Prednisolone in Acetic Acid-Induced Ulcerative Colitis in Male Albino Rats

“…"Carvedilol is a third-generation nonselective β-blocker that is used as antihypertensive drug and also in treatment of myocardial infarction" [10]. Carvedilol possesses both anti-apoptotic and anti-inflammatory properties [11] with mitochondrial protection ability [12]. It can also inhibit lipid peroxidation [13].…”