Betalains in Some Species of the Amaranthaceae Family: A Review

Miguel, Maria

doi:10.3390/antiox7040053

Cited by 122 publications

(89 citation statements)

References 225 publications

(381 reference statements)

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“…Stagnari, Galieni, Speca, & Pisante (2014) reported an increase of betacyanin by > 90% and > 70% in plants watered at 50% and 30% field capacity respectively compared to that of control plants (100% field capacity). The betacyanins in plants under water stress, as secondary metabolites, may function as scavengers of ROS, photoprotectants, and stress signals (Yang et al, 2018) and even as osmoregulants (Miguel, 2018).…”

confidence: 99%

Growth and Betacyanin Content of Beetroots (Beta vulgaris L.) Under Water Deficit in A Tropical Condition

2019

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confidence: 99%

Growth and Betacyanin Content of Beetroots (Beta vulgaris L.) Under Water Deficit in A Tropical Condition

2019

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“…The supplement used in our study consisted of a concentrate that was standardized to contain 12.5 mg of betalains separated from nitrates and sugars. Therefore, the absence of sugar, in addition to encapsulation, might have enhanced the absorption and bioavailability of the betalains (Miguel, 2018;Tesoriere et al, 2004), which could explain some of the observed discrepancies in our study. It is important to point out that our study examined muscle damage of the elbow flexors, not the knee extensors.…”

Section: Previous Work Bymentioning

confidence: 71%

The effects of betalain-rich concentrate supplementation in attenuating muscle damage following eccentric exercise

Vitti

Bruneau

Leyshon

et al. 2020

jhse

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Betalains are bioactive pigments that have been shown to reduce muscle damage and enhance recovery from exercise. However, to date, studies have examined the effects of betalains on aerobic exercise alone, and thus, their possible benefits for muscle damage recovery following eccentric exercise is unknown. We, therefore, aimed to examine the effects of a betalain-rich concentrate (BRC) on indices of muscle damage following eccentric exercise. Eleven healthy, recreationally active males were randomly assigned into a treatment group (50 mg of BRC, containing 12.5 mg of betalains, 3 times per day for 3 days) or a control group and performed 30 maximal eccentric contractions of the elbow flexors. Maximal voluntary contraction (MVC), arm circumference (AC), muscle soreness (MS), and range of motion (ROM) were measured before, immediately after, and 24, 48, and 72 hr following eccentric exercise. Creatine kinase (CK) was measured before, 24, 48, and 72 hr following the eccentric exercise. No significant differences or interactions were observed for any of the variables (p = > .05); however, a non-significant trend with a large effect size (p = .07, ηp 2 = 0.28) was found for the main effect for MVC. Although we failed to identify any statistically significant differences in any of the variables measured, the large effect size observed for MVC may have practical benefits in the enhancement of skeletal muscle recovery following eccentric exercise.

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“…Betalains are water-soluble nitrogenous pigments that are naturally occurring compounds that give colours to plants and have strong antioxidant activity (Miguel 2018). The health-promoting activities of betalains have been extensively studied in the context of their anticancer, anti-in ammatory, hepatoprotective and have been commercialized as dietary supplements and used in food colorants in the food industry (Kaur et al 2018).…”

Section: Keypointsmentioning

confidence: 99%

Betalain exerts a protective effect against glaucoma is majorly through the association of inflammatory cytokines

Wang

Zhang

Cao

et al. 2020

Preprint

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The present research aimed at evaluating the protective role of betalain on the in vitro glaucoma model using PC12 neuronal cells. The cultured neuronal cells in a customized pressurized chamber were analyzed for the onset of glutathione, myeloperoxidase (MPO), cathepsin, expression of inflammatory enzymes such as cyclooxygenase (COX-1), lipooxygenase (5- LOX), sPLA2 caveolin-1, glaucoma markers and other inflammatory cytokines in the presence and absence of betalain. The results have shown that a significant increase in the expression of oxidative stress with increased activity of cathepsin B and D. On the other hand, the activity of inflammatory enzymes such as COX-1, 5- LOX, sPLA2 were significantly increased in pressure exposed cells. In addition, glaucoma simulated cells demonstrated a significant increase in the VEGF, TGF-β, BDGF, and neuroserpin compared to control. Moreover, cells predisposed to hydrostatic pressure demonstrated an increase in (p<0.01) inflammatory cytokines such as IL-6, CXCR4, IL-17, IL-1β, and TNF-α levels. However, cells pre-treated with betalain improved the glutathione levels with attenuated MPO activity. Simultaneously, the levels of inflammatory cytokines and other glaucoma marker genes found restored in drug pre-treated cells. Thus, the results of the present study demonstrate that the use of betalain on ocular cells can prevent the progression of the disease that can be a suggestive therapeutic for controlling glaucoma like conditions.

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Betalains in Some Species of the Amaranthaceae Family: A Review

Cited by 122 publications

References 225 publications

Growth and Betacyanin Content of Beetroots (Beta vulgaris L.) Under Water Deficit in A Tropical Condition

Growth and Betacyanin Content of Beetroots (Beta vulgaris L.) Under Water Deficit in A Tropical Condition

The effects of betalain-rich concentrate supplementation in attenuating muscle damage following eccentric exercise

Betalain exerts a protective effect against glaucoma is majorly through the association of inflammatory cytokines

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