Betaine metabolism in human neonates and developing rats

Davies, S.; Chalmers, R. A.; Randall, E. W.; Iles, Richard A.

doi:10.1016/0009-8981(88)90232-x

Cited by 56 publications

(21 citation statements)

References 12 publications

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“…An increase of this betaine/creatinine ratio over the first 7 days of life was repeatedly observed and accorded to a higher total excretion of betaine [26][27][28][29][30]. Davies et al [26] reported a significant increase of the urine betaine/creatinine ratio in this time period.…”

Section: Discussionmentioning

confidence: 93%

1H-NMR metabolic profiling of human neonatal urine

Trump

Laudi²,

Unruh

et al. 2006

Magn Reson Mater Phy

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Section: Discussionmentioning

confidence: 93%

1H-NMR metabolic profiling of human neonatal urine

Trump

Laudi²,

Unruh

et al. 2006

Magn Reson Mater Phy

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“…Davies et al (36) have reported a very large urinary excretion of betaine in normal neonates and in young rats after weaning. High betaine concentrations are found in mammalian kidneys, particularly in the renal medulla.…”

Section: Discussionmentioning

confidence: 99%

Homocysteine Metabolism in ZDF (Type 2) Diabetic Rats

et al. 2005

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Mild hyperhomocysteinemia is a risk factor for many diseases, including cardiovascular disease. We determined the effects of insulin resistance and of type 2 diabetes on homocysteine (Hcy) metabolism using Zucker diabetic fatty rats (ZDF/Gmi fa/fa and ZDF/Gmi fa/?). Plasma total Hcy was reduced in ZDF fa/fa rats by 24% in the prediabetic insulin-resistant stage, while in the frank diabetic stage there was a 59% reduction. Hepatic activities of several enzymes that play a role in the removal of Hcy: cystathionine ␤-synthase (CBS), cystathionine ␥-lyase, and betaine:Hcy methyltransferase (BHMT) were increased as was methionine adenosyltransferase. CBS and BHMT mRNA levels and the hepatic level of S-adenosylmethionine were also increased in the ZDF fa/fa rats. Studies with primary hepatocytes showed that Hcy export and the transsulfuration flux in cells from ZDF fa/fa rats were particularly sensitive to betaine. Interestingly, liver betaine concentration was found to be significantly lower in the ZDf fa/fa rats at both 5 and 11 weeks. These results emphasize the importance of betaine metabolism in determining plasma Hcy levels in type 2 diabetes. Diabetes 54: 3245-3251, 2005

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“…Betaine showed to be the highest discriminating metabolite within the two groups and to a lesser extent DMG. Urinary betaine increases in concentration during the neonatal [32,33]. Dimethylglycine (DMG) is an amino acid derivative found in the cells of all animals and can be obtained through a diet in small amounts from grains and meat.…”

Section: Metabolitementioning

confidence: 99%