Betaine improved adipose tissue function in mice fed a high-fat diet: a mechanism for hepatoprotective effect of betaine in nonalcoholic fatty liver disease

Wang, Zhigang; Tong, Yao; Pini, Maria Silvia; Zhou, Zhanxiang; Fantuzzi, Giamila; Song, Zhenyuan

doi:10.1152/ajpgi.00249.2009

Cited by 129 publications

(123 citation statements)

References 44 publications

Supporting

Mentioning

109

Contrasting

Order By: Relevance

“…Betaine may also have a role as a glucose sensitizer. Betaine supplementation enhanced insulin sensitivity in diet-induced obese mice and increased insulin signaling pathway in isolated adipocytes (61). We found that 2 weeks of 5% betaine feeding increased Fgf21 expression by 7-fold in wild type liver.…”

Section: Discussionmentioning

confidence: 62%

Mouse Betaine-Homocysteine S-Methyltransferase Deficiency Reduces Body Fat via Increasing Energy Expenditure and Impairing Lipid Synthesis and Enhancing Glucose Oxidation in White Adipose Tissue

Teng

Ellis

Coleman

et al. 2012

Journal of Biological Chemistry

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 62%

Mouse Betaine-Homocysteine S-Methyltransferase Deficiency Reduces Body Fat via Increasing Energy Expenditure and Impairing Lipid Synthesis and Enhancing Glucose Oxidation in White Adipose Tissue

Teng

Ellis

Coleman

et al. 2012

Journal of Biological Chemistry

View full text Add to dashboard Cite

“…This was attributed to the normalization of insulin receptor substrate-1 (IRS-1) phosphorylation, a key protein involved in normal insulin signalling. Similarly, a recent study also showed that betaine improved adipose tissue function by reversing the suppressive effects of a high-fat diet in mice illustrated by increased levels of phosphorylated protein kinase b (p-Akt) and Akt [38]. Oxidative stress and hepatocyte apoptosis are seen as important factors in the progression of liver damage in NAFLD.…”

Section: Animal Studiesmentioning

confidence: 92%

Phosphatidylcholine functional foods and nutraceuticals: A potential approach to prevent non‐alcoholic fatty liver disease

Duric

Sivanesan

Bakovic

2012

Euro J Lipid Sci & Tech

View full text Add to dashboard Cite

Non‐alcoholic fatty liver disease (NAFLD) is the most common liver condition in the developed world and may progress to more severe forms of disease such as cirrhosis or liver cancer. Thus, steps taken to reduce its prevalence through preventative nutritional approaches such as functional foods and nutraceuticals (FFN) should be pursued. It is well known that certain lipotropic nutrients such as choline and metabolites betaine and phosphatidylcholine (PC; lecithin) could prevent or alleviate fatty liver through a variety of mechanisms, including increased hepatic VLDL secretion. Animal and human studies have demonstrated clear protective effects of choline, betaine and PC for NAFLD as well as possible roles in CVD prevention from epidemiological data. Currently, choline consumption is below dietary recommendations due in large part to a general lack of understanding regarding the importance of this nutrient for human health. As lecithin is commonly added (in small amounts) in many processed foods due to its functional capabilities, it is projected that increasing its abundance in the food supply and increasing consumer education and acceptance of lecithin‐based functional foods and nutraceuticals may represent a progressive step towards preventing liver and whole‐body metabolic pathologies in many areas of the world.

show abstract

“…Thus, further research in animal models and human intervention studies are needed to accurately define the relationship between supraphysiological intake of methyl donors and chronic diseases, and much care must be taken when recommending these compounds during pregnancy. In this sense, some recent studies have focused on beneficial effects of betaine supplementation in adipose tissue dysfunction and insulin resistance (Wang Z et al, 2010), and folate supplementation in obese subjects with type 2 diabetes (Gargari et al, 2011).…”

Section: Methyl Donorsmentioning

confidence: 99%

Dietary factors, epigenetic modifications and obesity outcomes: Progresses and perspectives

Milagro

Mansego

Miguel

et al. 2013

Molecular Aspects of Medicine

251

161

View full text Add to dashboard Cite

Nutritional factors play a life-long role in human health. Indeed, there is growing evidence that one of the mechanisms by which nutrients and bioactive compounds affect metabolic traits is epigenetics. Complex interactions among food components and histone modifications, DNA methylation, non-coding RNA expression and chromatin remodeling factors lead to a dynamic regulation of gene expression that controls the cellular phenotype. Although perinatal period is the time of highest phenotypic plasticity, contributing largely to developmental programming, also during adulthood there is evidence about a nutritional influence on epigenetic regulation. Similarly to type 2 diabetes, hypertension, atherosclerosis and other metabolic disorders, obesity predisposition and weight loss outcomes have been repeatedly associated to changes in epigenetic patterns. Different non-nutritional risk factors that usually accompany obesity seem also to be involved in these epigenetic modifications, especially hyperglycemia, inflammation, hypoxia and oxidative stress. There are currently three major objectives in epigenetic research in relation to obesity: to search for epigenetic biomarkers to predict future health problems or detect the individuals at most risk, to understand the obesity-related environmental factors that could modulate gene expression by affecting epigenetic mechanisms, and to study novel therapeutic strategies based on nutritional or pharmacological agents that can modify epigenetic marks. At this level, the major tasks are: development of robust epigenetic biomarkers of weight regulation, description of those epigenetic marks more susceptible to be modified by dietary exposures, identification of the active ingredients (and the doses) that alter the epigenome, assessment of the real importance of other obesity-related factors on epigenetic regulation, determination of the period of life in which best results are obtained, and understanding of the importance of the inheritance of these epigenetic marks.

show abstract

Betaine improved adipose tissue function in mice fed a high-fat diet: a mechanism for hepatoprotective effect of betaine in nonalcoholic fatty liver disease

Abstract: improved adipose tissue function in mice fed a high-fat diet: a mechanism for hepatoprotective effect of betaine in nonalcoholic fatty liver disease.

Cited by 129 publications

References 44 publications

Mouse Betaine-Homocysteine S-Methyltransferase Deficiency Reduces Body Fat via Increasing Energy Expenditure and Impairing Lipid Synthesis and Enhancing Glucose Oxidation in White Adipose Tissue

Mouse Betaine-Homocysteine S-Methyltransferase Deficiency Reduces Body Fat via Increasing Energy Expenditure and Impairing Lipid Synthesis and Enhancing Glucose Oxidation in White Adipose Tissue

Phosphatidylcholine functional foods and nutraceuticals: A potential approach to prevent non‐alcoholic fatty liver disease

Dietary factors, epigenetic modifications and obesity outcomes: Progresses and perspectives

Contact Info

Product

Resources

About