“…An observational clinical study reveals elevated levels of plasma TMAO were a strong risk marker for diabetes. Diabetic patients with high plasma TMAO levels was a marker of adverse cardiovascular outcomes, such as death (HR 2.7), myocardial infarction (HR 4.0), heart failure (HR 4.6), unstable angina (HR 9.1) and other cardiovascular complications (HR 2.0) [14]. Though the mechanisms behind the risk are undefined, TMAO could be a valuable marker to predict the risk of diabetes and its complications.…”