Betahistine dihydrochloride in the treatment of peripheral vestibular vertigo

Mira, E; Guidetti, G; Ghilardi, L; Fattori, Bruno; Malannino, N; Maiolino, Luigi; Mora, Renzo; Ottoboni, Stefano; Pagnini, P; Leprini, M; Pallestrini, E; Passàli, Desiderio; Nuti, Daniele; Russolo, M; Tirelli, Giancarlo; Simoncelli, C; Brizi, S.; Vicini, Claudio; Frasconi, Piercarlo

doi:10.1007/s00405-002-0524-4

Cited by 73 publications

(74 citation statements)

References 15 publications

(21 reference statements)

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“…They showed that, compared to placebo, betahistine is effective in reducing the frequency, severity, and duration of vertigo and of the associated neurovegetative symptoms, as well as in improving the patients' quality of life as evaluated by questionnaires. [30][31][32][33] Only a few studies used well-controlled paradigms and measures in the laboratory to specify the role of betahistine. They reported an effect of betahistine on the vestibulo-ocular reflex for paroxysmal vertigo patients.…”

Section: Abstract: Vestibular Pathology; Vestibular Compensation; Recmentioning

confidence: 99%

“…28 The present results are also in line with clinical studies indicating that betahistine reduced the intensity, frequency, and duration of vertigo symptoms of peripheral vestibular origin. [30][31][32][33] In patients with paroxysmal vertigo, betahistine reduced the gain of the vestibulo-ocular reflex. 34 Interestingly, these authors stressed that this drug treatment had no effect on visuo-vestibular interaction, suggesting that the site of action is in the vestibular nuclei.…”

Section: Figure 3 Effects Of Betahistine On Oculomotor Control Aftermentioning

confidence: 99%

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Betahistine Treatment Improves the Recovery of Static Symptoms in Patients With Unilateral Vestibular Loss

Redon

Lopez

Bernard-Demanze

et al. 2011

The Journal of Clinical Pharmacology

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Vestibular loss induces a combination of postural, oculomotor, and perceptive symptoms that are compensated over time. The aim of this study was to analyze the influence of betahistine dihydrochloride on vestibular compensation. A randomized, double-blind, placebo-controlled study was performed in Menière's disease patients who underwent a curative unilateral vestibular neurotomy (UVN). The effects of betahistine treatment were investigated on a broad spectrum of vestibular-induced changes resulting from vestibular loss: body sway, head orientation, ocular cyclotorsion, spontaneous nystagmus, verticality perception, and self-evaluation of the postural stability. The time course of the recovery was compared in 16 patients who received either a placebo or betahistine (24 mg b.i.d.) from 3 days up to 3 months after UVN. Patients were examined before (day -1) and after UVN (days 7, 30, and 90). Results indicate that betahistine reduces the time to recovery by 1 month or more depending on the tested functions. Betahistine was effective as soon as 4 days after treatment administration, and the effect remained during the whole compensation period (up to 3 months). The observed clinical effects may be attributed to an action of betahistine in rebalancing the neuronal activity between contralateral vestibular nuclei.

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Section: Abstract: Vestibular Pathology; Vestibular Compensation; Recmentioning

confidence: 99%

Section: Figure 3 Effects Of Betahistine On Oculomotor Control Aftermentioning

confidence: 99%

Betahistine Treatment Improves the Recovery of Static Symptoms in Patients With Unilateral Vestibular Loss

Redon

Lopez

Bernard-Demanze

et al. 2011

The Journal of Clinical Pharmacology

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“…Since the introduction of betahistine, it has been reported that its administration significantly reduces the incidence and severity of vertigo and produces a decrease in the incidence of nausea and emesis [1, 51, 75, 79, 81, 97, 98]. Its clinical effect has been attributed to increased blood flow in the vestibular system and cochlea [90].…”

Section: Drugs With Effects On Neurotransmitters and Neuromodulator Rmentioning

confidence: 99%

Neuropharmacology of Vestibular System Disorders

Soto¹,

Vega²

2010

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This work reviews the neuropharmacology of the vestibular system, with an emphasis on the mechanism of action of drugs used in the treatment of vestibular disorders. Otolaryngologists are confronted with a rapidly changing field in which advances in the knowledge of ionic channel function and synaptic transmission mechanisms have led to the development of new scientific models for the understanding of vestibular dysfunction and its management. In particular, there have been recent advances in our knowledge of the fundamental mechanisms of vestibular system function and drug mechanisms of action. In this work, drugs acting on vestibular system have been grouped into two main categories according to their primary mechanisms of action: those with effects on neurotransmitters and neuromodulator receptors and those that act on voltage-gated ion channels. Particular attention is given in this review to drugs that may provide additional insight into the pathophysiology of vestibular diseases. A critical review of the pharmacology and highlights of the major advances are discussed in each case.

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“…In a double-blind trial study, Oosterveld et al assessed the effect of betahistine on improving the vertigo in 24 patients, and showed that the severity of vertigo and also nausea and vomiting after taking betahistine has been significantly decreased [13]. Similarly, in a study conducted on 144 patients with vertigo, Simoncelli et al assessed the symptoms influence in the betahistine examined and showed that the frequency, severity and duration of attacks of vertigo in patients taking betahistine were significantly less, and also the quality of life before and after using the drug significantly improved [14]. In a randomized clinical trial, Alberta et al compared the effectiveness of betahistine with flunarizine in 52 patients with recurrent vertigo.…”

Section: Discussionmentioning

confidence: 99%

A Comparison of the Effects and Side Effects of Oral Betahistine with Injectable Promethazine in the Treatment of Acute Peripheral Vertigo in Emergency

Motamed¹,

Moezzi²,

Rooyfard³

et al. 2017

J Clin Med Res

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BackgroundVertigo is an illusion of rotation that is caused by the asymmetry of neurological function of the right and left vestibular nuclei. The aim of this study was to compare the efficacy and side effects of oral betahistine with injectable promethazine in treatment of acute peripheral vertigo.MethodsIn this double-blind clinical trial study, the patients with acute peripheral vertigo were assigned in the two groups: receiving promethazine intramuscularly at a dose of 25 mg (group A) and receiving 8 mg betahistine tablets (group B) and the severity of their vertigo was evaluated on the visual analog scale (VAS) scoring system. In addition, adverse events in both groups of patients were compared and evaluated.ResultsA total of 162 patients (82 subjects in group A) participated in this study. The mean age, gender distribution, intensity and symptoms of vertigo were similar in both groups before the intervention. At 2 and 3 h after the intervention, the score of VAS in patients taking betahistine was significantly higher than promethazine. In addition, the clinical symptoms after taking betahistine were significantly less. Side effects seen in patients taking the promethazine include mainly drowsiness. After taking betahistine, the most common complication was abdominal problems (nausea and vomiting).ConclusionThe results of this study show that betahistine is a safe and effective drug in controlling patients with acute vertigo and its impact is more than promethazine.

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Betahistine dihydrochloride in the treatment of peripheral vestibular vertigo

Cited by 73 publications

References 15 publications

Betahistine Treatment Improves the Recovery of Static Symptoms in Patients With Unilateral Vestibular Loss

Betahistine Treatment Improves the Recovery of Static Symptoms in Patients With Unilateral Vestibular Loss

Neuropharmacology of Vestibular System Disorders

A Comparison of the Effects and Side Effects of Oral Betahistine with Injectable Promethazine in the Treatment of Acute Peripheral Vertigo in Emergency

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