Beta2-containing neuronal nicotinic receptors as major actors in the flexible choice between conflicting motivations

Serreau, Pierre; Chabout, Jonathan; Suárez, Sandra; Naudé, Jérémie; Granon, Sylvie

doi:10.1016/j.bbr.2011.07.016

Cited by 20 publications

(27 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Percentage of H4 choices differed from days 1 and 2 to days 3, 4 and 5. These data indicated that the overall switch between high and low reward happened around 30–40 s for all animals, like it was shown before (Serreau et al 2011). As a result, all animals were able to discriminate a small reward from a large reward and to shift toward large choices when the delay was too long.…”

Section: Resultssupporting

confidence: 87%

“…The behavioral procedure was adapted from a previous work (Serreau et al 2011). Operant chambers contained two holes for nose poke.…”

Section: Methodsmentioning

confidence: 99%

“…A shift in the choices from the hole that gives high rewards to the hole that gives low rewards as a function of the delay before food delivery is taken as an index of the ability to wait for a larger reward and to control the frustration imposed by the delay (Serreau et al 2011). The percentage of H4 choices during each session was scored.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Individual behavioral and neurochemical markers of unadapted decision-making processes in healthy inbred mice

et al. 2016

View full text Add to dashboard Cite

One of the hallmarks of decision-making processes is the inter-individual variability between healthy subjects. These behavioral patterns could constitute risk factors for the development of psychiatric disorders. Therefore, finding predictive markers of safe or risky decision-making is an important challenge for psychiatry research. We set up a mouse gambling task (MGT)—adapted from the human Iowa gambling task with uncertain contingencies between response and outcome that furthermore enables the emergence of inter-individual differences. Mice (n = 54) were further individually characterized for locomotive, emotional and cognitive behavior. Individual basal rates of monoamines and brain activation after the MGT were assessed in brain regions related to reward, emotion or cognition. In a large healthy mice population, 44 % showed a balanced strategy with limited risk-taking and flexible choices, 29 % showed a safe but rigid strategy, while 27 % adopted risky behavior. Risky mice took also more risks in other apparatus behavioral devices and were less sensitive to reward. No difference existed between groups regarding anxiety, working memory, locomotion and impulsivity. Safe/rigid mice exhibited a hypoactivation of prefrontal subareas, a high level of serotonin in the orbitofrontal cortex combined with a low level of dopamine in the putamen that predicted the emergence of rigid behavior. By contrast, high levels of dopamine, serotonin and noradrenalin in the hippocampus predicted the emergence of more exploratory and risky behaviors. The coping of C57bl/6J mice in MGT enables the determination of extreme patterns of choices either safe/rigid or risky/flexible, related to specific neurochemical and behavioral markers.Electronic supplementary materialThe online version of this article (doi:10.1007/s00429-016-1192-2) contains supplementary material, which is available to authorized users.

show abstract

Section: Resultssupporting

confidence: 87%

“…The behavioral procedure was adapted from a previous work (Serreau et al 2011). Operant chambers contained two holes for nose poke.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Individual behavioral and neurochemical markers of unadapted decision-making processes in healthy inbred mice

et al. 2016

View full text Add to dashboard Cite

show abstract

“…As we showed that the “pro-social” behavior of β2 −/− mice was neither due to an impulsive phenotype nor to a biased evaluation of food or social reward values (Serreau et al, 2011), we wondered, here, whether β2 −/− mice exhibited difficulties in dealing with competing rewards when they can make free choice, in a safe environment. Indeed, in previous work (Serreau et al, 2011), we put in a same novel arena a novel conspecific and attractive food.…”

Section: Introductionmentioning

confidence: 99%

“…We previously showed that animals lacking beta2 subunit of neuronal nicotinic receptors (β2 −/− mice) showed impaired behavioral flexibility and difficulty to switch from one reward to another, whether the switch was between social interaction and food consumption, food retrieval and novelty exploration, or novelty exploration and social contact (Granon et al, 2003; Serreau et al, 2011). Particularly, in a social interaction task (SIT) designed to emphasize free social interaction, with potential risk of aggressiveness by an unknown conspecific (Cambon et al, 2010), we showed that β2 −/− mice exhibited higher level of dominance and lower level of flexibility, in relation with their prefrontal hyper-monoaminergia (Coura et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Making choice between competing rewards in uncertain vs. safe social environment: role of neuronal nicotinic receptors of acetylcholine

Chabout¹,

Cressant²,

Hu³

et al. 2013

Front. Hum. Neurosci.

View full text Add to dashboard Cite

In social environments, choosing between multiple rewards is modulated by the uncertainty of the situation. Here, we compared how mice interact with a conspecific and how they use acoustic communication during this interaction in a three chambers task (no social threat was possible) and a Social Interaction Task, SIT (uncertain situation as two mice interact freely). We further manipulated the motivational state of the mice to see how they rank natural rewards such as social contact, food, and novelty seeking. We previously showed that beta2-subunit containing nicotinic receptors-β2*nAChRs- are required for establishing reward ranking between social interaction, novelty exploration, and food consumption in social situations with high uncertainty. Knockout mice for β2*nAChRs-β2−/−mice- exhibit profound impairment in making social flexible choices, as compared to control -WT- mice. Our current data shows that being confronted with a conspecific in a socially safe environment as compared to a more uncertain environment, drastically reduced communication between the two mice, and changed their way to deal with a social conspecific. Furthermore, we demonstrated for the first time, that β2−/− mice had the same motivational ranking than WT mice when placed in a socially safe environment. Therefore, β2*nAChRs are not necessary for integrating social information or social rewards per se, but are important for making choices, only in a socially uncertain environment. This seems particularly important in the context of Social Neuroscience, as numerous animal models are used to provide novel insights and to test promising novel treatments of human pathologies affecting social and communication processes, among which Autistic spectrum disorders and schizophrenia.

show abstract

The Genetics of Impulsivity: A Synthesis of Findings in Humans and Rodent Models

Jupp

Dalley

2016

Animal Models of Behavior Genetics

View full text Add to dashboard Cite

Beta2-containing neuronal nicotinic receptors as major actors in the flexible choice between conflicting motivations

Cited by 20 publications

References 52 publications

Individual behavioral and neurochemical markers of unadapted decision-making processes in healthy inbred mice

Individual behavioral and neurochemical markers of unadapted decision-making processes in healthy inbred mice

Making choice between competing rewards in uncertain vs. safe social environment: role of neuronal nicotinic receptors of acetylcholine

The Genetics of Impulsivity: A Synthesis of Findings in Humans and Rodent Models

Contact Info

Product

Resources

About