Beta-glucan protects against isoproterenol-induced cardiac remodeling by regulating the ACE-AT<sub>1</sub>R axis and attenuates cardiac inflammation and apoptosis

Singaravel, Sengottuvelu; Roy, Anitha; Neelakantappa, VasanthaMallenahalli; Ganesan, Jayashree; Asokan, BalakrishnanRamajayam; Kulandaivel, Srinivasan; Uddandrao, V VSathibabu

doi:10.4103/2221-1691.385569

Asian Pac J Trop Biomed

2023

DOI: 10.4103/2221-1691.385569

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Beta-glucan protects against isoproterenol-induced cardiac remodeling by regulating the ACE-AT₁R axis and attenuates cardiac inflammation and apoptosis

Sengottuvelu Singaravel,

Anitha Roy,

VasanthaMallenahalli Neelakantappa

et al.

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2024

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Betulin protects against isoproterenol-induced myocardial injury by inhibiting NF-κB signaling and attenuating cardiac inflammation and oxidative stress in rats

Shah,

Gandhi

2024

Asian Pacific Journal of Tropical Biomedicine

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Objective: To investigate the cardioprotective potential of betulin in isoproterenol (ISO)-induced myocardial injury in rats. Methods: Wistar rats were divided into five groups (n=10): normal, ISO, nebivolol 5 mg/kg, and betulin (20 & 40 mg/kg). Nebivolol and betulin were administered orally for 29 days. ISO (85 mg/kg) was administered subcutaneously on day 27 and day 28 to induce myocardial injury. On day 29, blood was collected for determination of cardiac markers, and hemodynamic parameters were investigated. The levels of oxidative stress markers and the gene expressions of apoptotic markers and inflammatory mediators were evaluated. Moreover, 2,3,5-triphenyltetrazolium chloride staining and histopathological analysis were also performed. Results: Betulin reduced the size of myocardial infarction, decreased elevated levels of cardiac enzymes, and maintained hemodynamic functions. It also inhibited ISO-induced upregulation of Bax, caspase-3, NF-κB, and 1L-6, enhanced endogenous antioxidant enzymes, and reduced lipid peroxidation. Additionally, pretreatment with betulin alleviated myocardial ischemic damage, as reflected by reduced myonecrosis, edema, and inflammatory changes. Conclusions: Betulin exhibits strong cardioprotective activity against ISO-induced myocardial injury by anti-inflammatory, anti-apoptotic, and antioxidant activities.

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Betulin protects against isoproterenol-induced myocardial injury by inhibiting NF-κB signaling and attenuating cardiac inflammation and oxidative stress in rats

Shah,

Gandhi

2024

Asian Pacific Journal of Tropical Biomedicine

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Beta-glucan protects against isoproterenol-induced cardiac remodeling by regulating the ACE-AT₁R axis and attenuates cardiac inflammation and apoptosis

Cited by 1 publication

References 39 publications

Betulin protects against isoproterenol-induced myocardial injury by inhibiting NF-κB signaling and attenuating cardiac inflammation and oxidative stress in rats

Betulin protects against isoproterenol-induced myocardial injury by inhibiting NF-κB signaling and attenuating cardiac inflammation and oxidative stress in rats

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Beta-glucan protects against isoproterenol-induced cardiac remodeling by regulating the ACE-AT1R axis and attenuates cardiac inflammation and apoptosis

Cited by 1 publication

References 39 publications

Betulin protects against isoproterenol-induced myocardial injury by inhibiting NF-κB signaling and attenuating cardiac inflammation and oxidative stress in rats

Betulin protects against isoproterenol-induced myocardial injury by inhibiting NF-κB signaling and attenuating cardiac inflammation and oxidative stress in rats

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Beta-glucan protects against isoproterenol-induced cardiac remodeling by regulating the ACE-AT₁R axis and attenuates cardiac inflammation and apoptosis