Beta-endorphin in experimental canine spinal ischemia.

Riu, P.L. De; Petruzzi, V.; Palmieri, Giuseppe; Gentili, Claudia; Melis, Franco; Ma, Changqing; Azzena, Gianfranco; Casu, Anna; Marras, G; Madeddu, G

doi:10.1161/01.str.20.2.253

Cited by 15 publications

(8 citation statements)

References 25 publications

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“…Both groups exhibited similar pain responses as indicated by β -endorphin levels. A previous study indicated that serum β -endorphin levels over time in severely injured dogs exceeded the levels in moderately traumatized dogs [43]. The increases in serum concentrations due to painful stimuli remained elevated much longer than those due to nonpainful stimuli such as stress from handling [36].…”

Section: Discussionmentioning

confidence: 99%

Subcutaneous Administration of Tramadol after Elective Surgery Is as Effective as Intravenous Administration in Relieving Acute Pain and Inflammation in Dogs

Salisu

Hashim

Goh

et al. 2012

The Scientific World Journal

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Subcutaneous (SC) administration of tramadol was compared with intravenous (IV) administration to evaluate analgesia following canine ovariohysterectomy (OHE). Healthy female dogs (n = 12) between 1 and 3 years of age (1.95 ± 0.65 years), weighing between 10.5 and 17.1 kg (13.12 ± 1.95 kg), were used. Pain was assessed at baseline before surgery and then hourly for 8 hr after surgery. Tramadol was administered both SC and IV at a dose of 3 mg/kg and provided significant postoperative analgesia, as indicated by analgesiometry, β-endorphin levels, and interleukin 6 (IL-6) levels. The respiratory rates and rectal temperatures remained normal and were not significantly different between or within the groups. A significant increase in heart rate was observed at 4 hr for dogs in both groups relative to the baseline, but there was no significant difference in heart rates between the groups at any time point. A significant decrease in mechanical pain threshold was observed within each group after surgery, but both groups responded similarly, suggesting that SC administration of tramadol is as effective as IV administration. Increased serum levels of both IL-6 and β-endorphin 3 hr postoperatively further indicate that both routes of administration achieve similar pain control. Thus, the relative analgesic efficacy of SC tramadol is comparable to that of IV administration and can be used to achieve similar effects for postsurgical pain management in dogs undergoing OHE.

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Section: Discussionmentioning

confidence: 99%

Subcutaneous Administration of Tramadol after Elective Surgery Is as Effective as Intravenous Administration in Relieving Acute Pain and Inflammation in Dogs

Salisu

Hashim

Goh

et al. 2012

The Scientific World Journal

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show abstract

“…The intricate association between the immune and neuroendocrine systems through opioid pathways has been proposed for the past 10-15 years (23), and opioidinduced immunosuppression has been demonstrated (27). Increased endogenous 0-endorphin concentration is also associated with stress (10,11). Holaday (28) demonstrated that plasma P-endorphin levels increased 5-to 10-fold during endotoxemic shock in monkeys.…”

Section: Discussionmentioning

confidence: 99%

Possible Involvement of Endogenous -Endorphin in the Pathophysiological Mechanisms of Pichinde Virus-Infected Guinea Pigs

Guo

Liu

Peters

1992

Experimental Biology and Medicine

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Previously, we demonstrated that naloxone, an opiate antagonist, prolonged survival of strain 13 guinea pigs infected with Pichinde virus. Thus, endogenous opiates may be involved in the pathogenesis of this viral disease. To determine whether endogenous opiate levels were affected by Pichinde viral infection, beta-endorphin concentrations in plasma and cerebrospinal fluid (CSF) of normal and infected strain 13 guinea pigs were measured by radioimmunoassay. Cerebrospinal fluid beta-endorphin concentrations were 78.0 +/- 13.2 pg/ml on postinoculation day (PID) 7, 59.0 +/- 5.6 pg/ml on PID 12, and 58.8 +/- 5.4 pg/ml on PID 14. These values were significantly higher than baseline levels of CSF beta-endorphin: 30.8 +/- 1.9 pg/ml. Plasma beta-endorphin concentrations of infected animals increased significantly to 202.1 +/- 17.9 pg/ml on PID 7 and to 154.2 +/- 21.4 pg/ml on PID 12 from a mean baseline value of 84.2 +/- 13.1 pg/ml. After a primer intravenous injection of beta-endorphin (10, 15, or 30 micrograms/kg), followed by constant infusion of beta-endorphin (15, 45, or 90 micrograms/kg.hr) to control noninfected guinea pigs, heart rate (except with the lowest dose) and mean blood pressure decreased markedly. Under these experimental conditions, concentrations of plasma and CSF beta-endorphin increased simultaneously with different magnitude. Because both Pichinde viral infection and beta-endorphin administration produced a similar trend of cardiovascular disturbances, leading to hypotension and bradycardia, increased concentrations of plasma and CSF beta-endorphin may play a partial role in the pathophysiological mechanisms of Pichinde virus infection.

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“…It has been reported that naloxone, an opiate antagonist, improves neurologic recovery from trauma and spinal cord ischemia. 74,75 Acher et al 13 found that naloxone with CSF drainage effectively lowered the incidence of spinal cord injury in patients undergoing thoracic and thoracoabdominal aneurysm repair.…”

Section: Administration Of Neuroprotective Agentsmentioning

confidence: 99%

Spinal Cord Protection During Thoracoabdominal Aneurysm Repair

Tabayashi

2005

Surg Today

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Spinal cord injury after thoracoabdominal aortic surgery remains a devastating and unpredictable complication, caused by clamping of the thoracoabdominal aorta, resulting in exclusion of blood flow in critical and essential intercostal arteries. Various protective methods against spinal cord ischemia have been proposed and performed clinically. These include preoperative spinal angiography, distal aortic perfusion, hypothermia, reattachment of the intercostal artery, cerebrospinal fluid drainage, administration of neuroprotective agents, and monitoring of somatosensory and motor-evoked potentials. The information to date suggests that multimodality approaches should be used to prevent spinal cord injury after thoracic and thoracoabdominal aneurysm repair.

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Beta-endorphin in experimental canine spinal ischemia.

Cited by 15 publications

References 25 publications

Subcutaneous Administration of Tramadol after Elective Surgery Is as Effective as Intravenous Administration in Relieving Acute Pain and Inflammation in Dogs

Subcutaneous Administration of Tramadol after Elective Surgery Is as Effective as Intravenous Administration in Relieving Acute Pain and Inflammation in Dogs

Possible Involvement of Endogenous -Endorphin in the Pathophysiological Mechanisms of Pichinde Virus-Infected Guinea Pigs

Spinal Cord Protection During Thoracoabdominal Aneurysm Repair

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