Beta-endorphin, immunological and biochemical changes in synovial fluid in rheumatic disorders

Denko, Charles W.; Aponte, Julio; Peltre, Gabriel; Petricevic, M

doi:10.1007/bf02030964

Cited by 16 publications

(8 citation statements)

References 9 publications

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“…As early as 1986, endogenous opioids have been described in the synovial fluid of patients with RA (26). Similarly, nerve fibers containing endogenous opioids have been observed in the synovial tissue of patients with RA and patients with OA (27).…”

Section: Discussionmentioning

confidence: 99%

Antiinflammatory role of endomorphins in osteoarthritis, rheumatoid arthritis, and adjuvant‐induced polyarthritis

Straub¹,

Wolff²,

Faßold³

et al. 2008

Arthritis & Rheumatism

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Objective. Pain sensitization and the related secretion of neuropeptides from sensory nerve terminals are proinflammatory in osteoarthritis (OA), rheumatoid arthritis (RA), and adjuvant-induced polyarthritis. In contrast, endogenous opioids such as the recently discovered endomorphins (EMs) are antiinflammatory. However, the role of endogenous EMs such as EM-1 and EM-2 has never been investigated in OA and RA.Methods. We established a highly sensitive radioimmunoassay to detect EM-1 and EM-2. In patients with RA and patients with OA, immunohistochemistry for EM-1 and EM-2 was performed, and double-staining was used to identify EM-positive cells. The effects of EM-1 and EM-2 on the secretion of interleukin-6 (IL-6) and IL-8 from human synovial tissue were studied by tissue superfusion, and the therapeutic effects of EM-1 were tested in a rat model of adjuvant-induced polyarthritis.Results. EM-positive cells were located in the sublining area and vessel walls but were particularly evident in the highly inflamed lining area. Human macrophages, T cells, and fibroblasts stained positive for EMs. The synovial density of EM-positive cells was higher in patients with OA than in those with RA.

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Section: Discussionmentioning

confidence: 99%

Antiinflammatory role of endomorphins in osteoarthritis, rheumatoid arthritis, and adjuvant‐induced polyarthritis

Straub¹,

Wolff²,

Faßold³

et al. 2008

Arthritis & Rheumatism

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“…13 END has also been identified within inflamed synovial tissue of patients suffering from knee injury or chronic arthritis. [14][15][16] In a previous clinical trial, we found a dose-dependency of intra-articular (i.a.) morphine analgesia.…”

Section: Introductionmentioning

confidence: 88%

Increased numbers of opioid expressing inflammatory cells do not affect intra-articular morphine analgesia

Likar

Mousa

Philippitsch

et al. 2004

British Journal of Anaesthesia

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“…Major depression is associated with elevated levels of MOR and βendorphins, 26 and the synovial membrane probably produces β-endorphin. 104 In recent years, substantial research points to the role of the EOS and their receptors in response to stress, mood regulation, and the pathophysiology of MDD. 52 Activation of immune-inflammatory pathways is likely responsible for circulating levels of β-endorphin and other EOS markers (such as MOR and KOR) during inflammatory conditions.…”

Section: Other Biomarkers Of Pp Due To Ramentioning

confidence: 99%

Depression, anxiety, and chronic fatigue symptoms in acute rheumatoid arthritis are associated with immune-inflammatory, autoimmune, endogenous opioid system and lactosylceramide signaling pathways: a nomothetic network approach

Smesam¹,

Qazmooz

Khayoon

et al. 2021

Preprint

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Background. Rheumatoid arthritis (RA) is a chronic inflammatory and autoimmune disorder which affects the joints in the wrists, fingers, and knees. RA is often associated with depressive and anxiety symptoms as well as chronic fatigue syndrome (CFS)-like symptoms. Aim. To examine the association between depressive symptoms (measured with the Beck Depression Inventory, BDI), anxiety (Hamilton Anxiety Rating Scale, HAMA), and CFS-like (Fibro-fatigue Scale) symptoms and immune-inflammatory, autoimmune, and endogenous opioid system (EOS) markers, and lactosylceramide in RA. Methods. Serum biomarkers were assayed in RA patients with (n=59) and without (n=59) increased psychopathology (PP) and 50 healthy controls. Results. There were highly significant correlations between the BDI, FF, and HAMA scores and severity of RA, as assessed with the DAS28-4, clinical and disease activity indices, the number of tenders and swollen joints, and patient and evaluator global assessment scores. A common latent vector (reflective model) could be extracted from the PP and RA-severity scales, which showed excellent psychometric properties. Partial least squares analysis showed that 69.7% of the variance in this common core underpinning PP and RA symptoms could be explained by the regression on immune-inflammatory pathways, rheumatoid factor and anti-citrullinated protein antibodies, CD17, and mu-opioid receptor levels. Conclusions. Depression, anxiety, and CFS-like symptoms due to RA are reflective manifestations of the phenome of RA and are mediated via the effects of the same immune-inflammatory, autoimmune, and EOS pathways and lactosylceramide that underpin the pathophysiology of RA. These PP symptoms are clinical manifestations of the pathophysiology of RA.

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Beta-endorphin, immunological and biochemical changes in synovial fluid in rheumatic disorders

Cited by 16 publications

References 9 publications

Antiinflammatory role of endomorphins in osteoarthritis, rheumatoid arthritis, and adjuvant‐induced polyarthritis

Antiinflammatory role of endomorphins in osteoarthritis, rheumatoid arthritis, and adjuvant‐induced polyarthritis

Increased numbers of opioid expressing inflammatory cells do not affect intra-articular morphine analgesia

Depression, anxiety, and chronic fatigue symptoms in acute rheumatoid arthritis are associated with immune-inflammatory, autoimmune, endogenous opioid system and lactosylceramide signaling pathways: a nomothetic network approach

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