Beta-cypermethrin impairs reproductive function in male mice by inducing oxidative stress

Wang, X.-Z.; Liu, S.-S.; Sun, Yunjun; Wu, Jiayuan; Zhou, Yingqun; Zhang, J.-H.

doi:10.1016/j.theriogenology.2009.04.016

Cited by 112 publications

(76 citation statements)

References 45 publications

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“…It differed from the control group by having lower spermatozoa density. This observation corroborates the work of Wang et al [15], where qualitative analyses revealed that low dose (1mg/ kg) of beta-Cypermethrin decreased the number of interstitial Leydig cells but did not affect the intratubular compartment of seminiferous tubules, as the concentration of beta-Cypermethrin increased, the number of spermatids and cells in the seminiferous tubules appeared to decrease; moreover, some cells began to slough. At the high beta- Cypermethrin dose, only vacuolized primary spermatocytes were observed.…”

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 89%

“…In contrast, Wang et al [15], reported that Cypermethrin decreases testicular weight and the weight of the male sexual accessory glands. Three doses of beta -Cypermethrin decreased body weight gain and weight of testosterone-sensitive organs such as testes, epididymis, seminal vesicles and prostate [15,16]. Cytotoxic effects of aerosols of the pyrethroid insecticide Matox ® on male rats exposed to Matox ® daily up to 2, 4 and 8 weeks, which exhibited a signi icant decrease in weights of testes, epididymis, seminal vesicle and prostate glands have been reported [17].…”

Section: Discussionmentioning

confidence: 89%

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Pathological Effects of Cypermethrin on the Testes and Accessory Sexual Glands of Yankasa Rams

Simon¹

2017

Arch Pathol Clin Res

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An investigation into the pathological lesions of Cypermethrin on the testes, accessory sexual and pituitary glands of Yankasa rams was carried out. Sixteen Yankasa rams aged 18 -30 months and weighing between 21.5 -46.5kg were used. The 16 rams were divided equally into two groups (A and B) A served as the treatment group while B served as the control. Group (A) were given Cypermethrin (3%) at the dose rate of 3mg/kg (0.1ml/kg) body weight, topically. Group (B) rams were given distilled water at the same dose rate and route. These treatments were repeated every two weeks for a period of 12 weeks. The rams were sacrifi ced at the end of 12 weeks and the following organs (testes, pituitary, vesicular and prostate glands), were collected and weighed, gross pathological lesions were observed and photographs were taken. The samples were kept for histopathology. Results showed that there were no gross pathological lesions found on the testes, pituitary, prostate glands and the seminal vesicles of both groups. The mean weight of the pituitary gland, the prostate glands and the seminal vesicles of the treated and control groups were statistically not signifi cant (P>0.05). No histologic lesions were found on them. The mean testicular weights of the treated (143.81±7.71g) and the control (130.43±0.63g) were signifi cantly different (P<0.05). There was a reduced number of spermatozoa in the lumen of the seminiferous tubules of the treated group. It was concluded that Cypermethrin reduced spermatozoa in the lumen of the seminiferous tubules.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 89%

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Pathological Effects of Cypermethrin on the Testes and Accessory Sexual Glands of Yankasa Rams

Simon¹

2017

Arch Pathol Clin Res

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“…The disagreement here is in terms of sperm abnormalities. All doses of 1, 10 and high dose 20 mg/kg beta Cypermethrin used in a 36 day experiment decreased sperm count, viability and intact acrosome rate (Wang et al, 2009). A significant (P<0.05) increase in the proportion of dead and abnormal sperm cells in mice exposed to Cypermethrin have been reported (Bhunya and Pati, 1988).…”

Section: Discussionmentioning

confidence: 92%

“…Pesticide exposure is associated with infertility, there is much concern that exposure to environmental contaminants causes decreased sperm counts, impairment of sperm motility, reduced fertilization ability, producing abnormal sperm in men and wildlife (Elbetieha et al, 2001). The mechanism by which Cypermethrin affects male reproduction is unclear (Wang et al, 2009). This work was designed to make further observations on the specific types of sperm abnormalities present in label dose Cypermethrin treated rams and contribute information towards understanding how Cypermethrin affects male's reproduction.…”

Section: Introductionmentioning

confidence: 99%

Specific sperm abnormalities observed in rams (Ovis aries) following cypermethrin treatment

Azubuike¹,

Ogwu²,

Ibrahim³

et al. 2017

J. Cell Anim. Biol.

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This work was designed to make further observations on the specific types of sperm abnormalities present in Cypermethrin treated rams and contribute information towards understanding how Cypermethrin affects male's reproduction. Sixteen sexually-mature, healthy Yankasa rams aged 18 to 30 months and weighing between 21.5 to 46.5 kg were used. The 16 rams were divided equally into two groups (A and B). Group A served as the treatment group, while B served as the control. The rams in Group A were given Cypermethrin (3%) at the dose rate of 3 mg/kg (0.1 ml/kg) body weight, topically as pour-on. The control rams were given distilled water at the same dose rate and route. These treatments were repeated every two weeks for a period of 12 weeks. Semen was collected on weekly basis from each ram during the experimental period by means of a hand held electro-ejaculator (EE). The morphological sperm abnormalities/defects were determined by examining semen smears stained with eosin-nigrosin on a glass slide. Results showed that sperm abnormalities recorded were detached head, mid piece droplet, free tail, coiled tail and bent tail. There was no significant difference in the percentage of these abnormalities recorded between the two groups (p>0.05) from week 1 to 12. It is concluded that Cypermethrin did not induce any specific sperm abnormalities in rams treated with 3 mg/kg body weight as pour-on. Sperm death in Cypermethrin label dose treated rams may be mediated through oxidative stress. It was recommended that more studies be directed towards stress biomarkers in Cypermethrin treated rams.

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Evaluation of the effects of deltamethrin on the fetal rat testis

et al. 2016

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Pregnant Sprague-Dawley rats were administered deltamethrin, at doses 0.1, 1, 5 or 10 mg kg(-1) day(-1) , or di-n-hexyl phthalate (DnHP) (250 mg kg(-1) day(-1) ), by gavage, from gestational day 13 to 19. Maternal toxicity was observed at 10 mg kg(-1) day(-1) , as evidenced by transient clinical signs of neurotoxicity and reductions in body weight, body weight gain and corrected weight gain. Deltamethrin had no statistically significant effect on the incidence of post-implantation loss, fetal weight or anogenital distance in the male fetuses. Unlike DnHP, deltamethrin induced no changes in the expression of several genes involved in cholesterol transport or in the steroid synthesis pathway in the testes of gestational day 19.5 male fetuses (SRB1, StAR, P450scc, 3βHSD, P450 17 A1, 17βHSD). Fetal testicular levels of P450scc and P450 17 A1 protein were also unaffected by deltamethrin. No statistically significant differences were observed in the ex vivo fetal testicular production of testosterone and androstenedione after deltamethrin exposure, whereas DnHP markedly reduced these parameters. The deltamethrin metabolite, 3-phenoxybenzoic acid, was detected in amniotic fluid. In summary, our results demonstrate that in utero exposure to deltamethrin during the period of sexual differentiation had no significant effect on the testosterone synthesis pathway in the male rat fetus up to a maternal toxic dose. Copyright © 2016 John Wiley & Sons, Ltd.

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Beta-cypermethrin impairs reproductive function in male mice by inducing oxidative stress

Cited by 112 publications

References 45 publications

Pathological Effects of Cypermethrin on the Testes and Accessory Sexual Glands of Yankasa Rams

Pathological Effects of Cypermethrin on the Testes and Accessory Sexual Glands of Yankasa Rams

Specific sperm abnormalities observed in rams (Ovis aries) following cypermethrin treatment

Evaluation of the effects of deltamethrin on the fetal rat testis

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