Beta-Cell Pyroptosis – A Burning Flame in Type 1 Diabetes?
Caroline Frørup,
Cecilie Amalie Søndergaard Svane,
Kristine Henriksen
et al.
Abstract:Immune-mediated destruction of the beta-cells in the pancreatic islets of Langerhans is the underlying cause of type 1 diabetes (T1D). Despite decades of research, the exact mechanisms involved at the beta-cell level during the development of disease remain poorly understood. This includes the mode(s) of beta-cell death and signaling events implicated in exacerbating local islet inflammation and immune cell infiltration, commonly known as insulitis. In disease models, beta-cell apoptosis seems to be the predom… Show more
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