Beta cell protective effect of Curcuma longa and Piper nigrum in cytokine cocktail induced apoptosis in Min6 pancreatic beta cells

Damame, Hemangee; Rooge, Sheetalnath; Patil, Rahul; Garad, Chandramukhi; Arvindekar, Akalpita U.

doi:10.1016/j.phyplu.2021.100072

Cited by 5 publications

(5 citation statements)

References 24 publications

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“…We also showed that by using Tinospora cordifolia , it is possible to differentiate human pancreatic duct–derived PANC‐1 cells into functional beta cells 380 . After providing in vitro cytokine cocktail‐based model to assess and screen compounds that can protect apoptosis of β‐cells and retard the progress of T1DM, 381 in another interesting study, we proved that aqueous extract of Curcuma longa and Piper nigrum were able to protect β‐cells against apoptosis and can be implemented as an oral herbal treatment for T1DM 382 . Considering other studies, researchers addressed the natural compound “C‐Phycocyanin” as an effective pigment protein in T2DM 383 .…”

Section: Therapeutic Challenges and Current Remedies To Treat Diabete...mentioning

confidence: 89%

“…380 After providing in vitro cytokine cocktail-based model to assess and screen compounds that can protect apoptosis of β-cells and retard the progress of T1DM, 381 in another interesting study, we proved that aqueous extract of Curcuma longa and Piper nigrum were able to protect β-cells against apoptosis and can be implemented as an oral herbal treatment for T1DM. 382 Considering other studies, researchers addressed the natural compound "C-Phycocyanin" as an effective pigment protein in T2DM. 383 Gold nanoparticles encapsulated with metformin are also evidenced as prompt antiglycation agents.…”

Section: Diabetes and Neurodegenerative Diseasesmentioning

confidence: 99%

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Communal interaction of glycation and gut microbes in diabetes mellitus, Alzheimer's disease, and Parkinson's disease pathogenesis

Patil,

Tupe

2023

Medicinal Research Reviews

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Diabetes and its complications, Alzheimer's disease (AD), and Parkinson's disease (PD) are increasing gradually, reflecting a global threat vis‐à‐vis expressing the essentiality of a substantial paradigm shift in research and remedial actions. Protein glycation is influenced by several factors, like time, temperature, pH, metal ions, and the half‐life of the protein. Surprisingly, most proteins associated with metabolic and neurodegenerative disorders are generally long‐lived and hence susceptible to glycation. Remarkably, proteins linked with diabetes, AD, and PD share this characteristic. This modulates protein's structure, aggregation tendency, and toxicity, highlighting renovated attention. Gut microbes and microbial metabolites marked their importance in human health and diseases. Though many scientific shreds of evidence are proposed for possible change and dysbiosis in gut flora in these diseases, very little is known about the mechanisms. Screening and unfolding their functionality in metabolic and neurodegenerative disorders is essential in hunting the gut treasure. Therefore, it is imperative to evaluate the role of glycation as a common link in diabetes and neurodegenerative diseases, which helps to clarify if modulation of nonenzymatic glycation may act as a beneficial therapeutic strategy and gut microbes/metabolites may answer some of the crucial questions. This review briefly emphasizes the common functional attributes of glycation and gut microbes, the possible linkages, and discusses current treatment options and therapeutic challenges.

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Section: Therapeutic Challenges and Current Remedies To Treat Diabete...mentioning

confidence: 89%

Section: Diabetes and Neurodegenerative Diseasesmentioning

confidence: 99%

Communal interaction of glycation and gut microbes in diabetes mellitus, Alzheimer's disease, and Parkinson's disease pathogenesis

Patil,

Tupe

2023

Medicinal Research Reviews

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“…However, chronic inflammation is known to induce pancreatic β-cell injury and dysfunction, inhibit insulin-mediated glucose uptake and lead to hepatic insulin resistance, as characterized by impaired insulin-induced suppression of hepatic gluconeogenesis [8,46]. An aqueous extract of C. longa was reported to decrease lipid peroxidation-induced DNA damage [47], and an herb mixture containing C. longa extract was shown to protect pancreatic β-cell injury from an inflammatory cytokine cocktail consisting of TNF-α, IL-1β, and interferon-γ [48]. In addition, an ex vivo study found that an aqueous extract of C. longa increased the secretion of insulin in pancreatic tissue and promoted insulin-induced glucose uptake in muscle tissue by activating PI3K/Akt signaling [49,50].…”

Section: Discussionmentioning

confidence: 99%

A Hot Water Extract of Curcuma longa L. Improves Fasting Serum Glucose Levels in Participants with Low-Grade Inflammation: Reanalysis of Data from Two Randomized, Double-Blind, Placebo-Controlled Trials

Uchio¹,

Okuda-Hanafusa²,

Saji³

et al. 2022

Nutrients

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The dietary spice Curcuma longa L. (C. longa), also known as turmeric, has various biological effects. A hot water extract of C. longa was shown to have anti-inflammatory activities in preclinical and clinical studies. Chronic low-grade inflammation is associated with the disruption of glucose homeostasis, but the effect of C. longa extract on glucose metabolism in humans is poorly understood. Therefore, we investigated the effect of C. longa extracts on serum glucose levels in the presence of low-grade inflammation. We reanalyzed our published data from two randomized, double-blind, placebo-controlled trials in overweight participants aged 50 to 69 years and performed a stratified analysis using the inflammatory marker high-sensitivity C-reactive protein (hsCRP). In both studies, participants took a test food with a hot water extract of C. longa (C. longa extract group, n = 45 per study) or without C. longa extract (placebo group, n = 45 per study) daily for 12 weeks, and we measured the levels of serum hsCRP and fasting serum glucose. The mean baseline hsCRP value was used to stratify participants into two subgroups: a low-hsCRP subgroup (baseline mean hsCRP < 0.098 mg/dL) and a high-hsCRP subgroup (baseline mean hsCRP ≥ 0.098 mg/dL). In the low-hsCRP subgroup, we found no significant difference in fasting serum glucose levels between the two groups in either study, but in the high-hsCRP subgroup, the C. longa extract group had significantly lower levels of serum hsCRP (p < 0.05) and fasting serum glucose (p < 0.05) than the placebo group in both studies. In conclusion, a hot water extract of C. longa may help to improve systemic glucose metabolism in people with chronic low-grade inflammation.

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“…In the aforementioned combination study, carbohydrate metabolism was modulated by enhancing glucose regulation, improving insulin sensitivity, and increasing glucose uptake in a rat model of insulin resistance and T2DM (T2DM) through a combination of fenugreek seed, mulberry leaf extracts, and American ginseng [ 65 ]. Similarly, in another study, a combination exhibited notable hypoglycemic, antioxidant, and hypolipidemic properties in streptozotocin (STZ)-induced diabetic rats.…”

Section: Polyherbalism In the Management And Treatment Of Dmmentioning

confidence: 99%

“…Similarly, in another study, a combination exhibited notable hypoglycemic, antioxidant, and hypolipidemic properties in streptozotocin (STZ)-induced diabetic rats. This botanical combination significantly ameliorated glycemia, total cholesterol, triglycerides, LDL-cholesterol, malondialdehyde (MDA), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and creatinine concentration, while increasing HDL-cholesterol, glutathione, and total antioxidant status (TAOS) [ 65 ]. By amalgamating these findings, it becomes evident that combining medicinal plant extracts offers synergistic benefits by targeting multiple pathways involved in carbohydrate metabolism, insulin sensitivity, oxidative stress, and lipid profiles.…”

Section: Polyherbalism In the Management And Treatment Of Dmmentioning

confidence: 99%

Review on the Anti-Hyperglycemic Potential of Psidium guajava and Seriphium plumosum L.

Thembane,

Hlatshwayo,

Ngcobo

et al. 2024

Plants

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The treatment and management of diabetes mellitus (DM) with conventional therapies, such as insulin injections and oral hypoglycemic agents, present significant challenges due to their side effects and burdensome administration. Therapies often manage symptoms rather than addressing insulin regulation, akin to medications like thiazolidinediones and glinides, which resemble many medicinal plants. Medicinal plants offer potential alternative treatments due to bioactive compounds targeting diabetes causes. We aimed to explore the antidiabetic potential of two medicinal plants, Psidium guajava and Seriphium plumosum L., by investigating their phytochemical constituents, medicinal uses, pharmacological actions, and mechanisms. This review followed specific guidelines and searched databases including PubMed, Scopus, ScienceDirect, and Web of Science for studies on medicinal plants and DM. Eligible studies underwent quality assessment and were categorized based on their design and interventions for data synthesis. This review identified the phytochemical constituents in Psidium guajava and Seriphium plumosum L., including tannins, flavonoids, phenols, and steroids, exerting antidiabetic effects through various mechanisms like antioxidant activity, anti-inflammatory effects, stimulation of insulin secretion, glucose regulation, and inhibition of carbohydrate-digesting enzymes. Psidium guajava and Seriphium plumosum L. exhibit promising antidiabetic potential, offering alternative approaches to diabetes management. Polyherbalism, combining multiple plant extracts, may enhance therapeutic efficacy in diabetes treatment. Comprehensive research is needed to explore the combined therapeutic effects of these plants and develop more effective antidiabetic treatments. This review highlights the importance of harnessing natural resources to combat the global burden of DM. Further research is warranted to fully explore the combined therapeutic effects of these plants and develop novel treatments.

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Beta cell protective effect of Curcuma longa and Piper nigrum in cytokine cocktail induced apoptosis in Min6 pancreatic beta cells

Cited by 5 publications

References 24 publications

Communal interaction of glycation and gut microbes in diabetes mellitus, Alzheimer's disease, and Parkinson's disease pathogenesis

Communal interaction of glycation and gut microbes in diabetes mellitus, Alzheimer's disease, and Parkinson's disease pathogenesis

A Hot Water Extract of Curcuma longa L. Improves Fasting Serum Glucose Levels in Participants with Low-Grade Inflammation: Reanalysis of Data from Two Randomized, Double-Blind, Placebo-Controlled Trials

Review on the Anti-Hyperglycemic Potential of Psidium guajava and Seriphium plumosum L.

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