Beta-Cell Function and Failure in Type 1 Diabetes

Lazo-de-la-Vega-Monroy, Maria-Luisa; Fernández-Mejía, Cristina

doi:10.5772/22089

Cited by 9 publications

(5 citation statements)

References 129 publications

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“…1 En humanos, aproximadamente el 55% de las células del islote la conforman células beta y en ratón entre el 70-80% son células-beta. 2,3…”

Section: Páncreas Endócrinounclassified

Cambios en los islotes pancreáticos maternos después de la lactancia

Canul,

Negrete,

Hidalgo

et al. 2024

Acta Pediatr Mex

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Los islotes pancreáticos se adaptan ante diferentes demandas metabólicas y cambios hormonales a través de la modificación en su tamaño y secreción hormonal. Poca información existe acerca de los islotes pancreáticos maternos y el metabolismo de la glucosa materna después de la lactancia. Nuestro equipo de trabajo examinó la morfología de los islotes maternos y la homeostasis de la glucosa después de la lactancia en ratones de la cepa C57BL/6. Después de la lactancia, se encontró un incremento en el tamaño de los islotes y la proliferación de los islotes materno. También se modificó la secreción de insulina, tolerancia a la glucosa y sensibilidad a la insulina. Estos resultados abren un nuevo campo de oportunidades para la identificación de moléculas y mecanismos que participen en estos procesos y que ayuden en el desarrollo de estrategias para combatir la diabetes.

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“…1 En humanos, aproximadamente el 55% de las células del islote la conforman células beta y en ratón entre el 70-80% son células-beta. 2,3…”

Section: Páncreas Endócrinounclassified

Cambios en los islotes pancreáticos maternos después de la lactancia

Canul,

Negrete,

Hidalgo

et al. 2024

Acta Pediatr Mex

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“…Gangguan sinyal Ca 2+ juga ditemukan di neuron sensorik dari hewan eksperimental dengan diabetes. 3,4 Ada perbedaan mekanisme keseimbangan Ca 2+ intrasel pada berbagai tipe sel, contohnya pada sel otot skeletal dan sel T, pada sel otot skeletal komponen untuk sinyal Ca 2+ menghantar lebih cepat karena diperlukan untuk kontraksi otot, sedangkan pada sel T lebih lambat karena sinyal Ca 2+ diperlukan hanya untuk stimulasi dan proliferasi. 5 Prinsip Tranduksi Sinyal Intrasel.…”

Section: Pendahuluanunclassified

INTRACELLULAR Ca2+ HOMEOSTASIS

Kurniawan

2015

MNJ

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Abstracr , Many metals act on biological systems at low concentrations and recent epidemiological and experimental research indicates that toxic effects of certain metals occur at levels only marginally higher than those found in healthy subjects. Despite a large number of studies describing metal cytotoxicity, the molecular mechanisms involved are still poorly understood. However, it now seems evident that several metals can interact with enzyme functional groups and that proteins involved in signal transduction, including CaZ+ channels and pumps, may be especially sensitive to this interaction. Impairment of the ability of cells to adequately respond to the stimulation by hormones and growth factors may result in the loss of important cell functions or activation of mechanisms that compromise cell survival. In the following sections we will briefly describe the effects of various metals on cell signalling and present our recent findings on the mechanism by which inorganic mercury affects signal transduction. Barnes , D. S. : Cells without growth factor commit suicide. Science l988,242,1510-1511. kinetic analysis of the effect of adrenalin on calcium distribution in isolated rat liver parenchymal cells. J. Physiol. 1981,312,29-55. Bellomo, G., H. Thor & S. Orrenius: Alterations in inositol phosphate production during oxidative stress in isolated hepatocytes. J. Biol. Chem. 1987,262,1530-1534. Berlin, M., J. Carlson & T. Norseth: Dose-dependence of methylmer-cury metabolism. A study of distribution: biotransformation and excretion in squirrel monkey. Arch. Environ. Health 1975, 30, Berridge, M. J.: Inositol trisphosphate and diacylglycerol: two interacting second messengers. Annu. Rev. Biochem. 1987,56,159-193. Berridge, M. J.: Calcium oscillation. J. Bid. Chem. 1991, 265, Bingham-Smith, J., S. D. Dwyer & L. Smith: Cadmium evokes inosi-to1 polyphosphate formation and calcium mobilization. J. Biol. Chem. 1989,264,7115-7118. Bondy, S. C. & A. K. Agrawal: The inhibition ofcerebral high affinity receptor sites by lead and mercury compounds. Arch. Toxicol. Bottestein, J. E.: Growth and differentiation of neural cells in defined media. In: Cell culture in the neurosciences.: Evidence for the involvement of dithiol groups in mitochondria1 calcium transport: studies with cadmium. Arch. Biochem. Biophys. 1985, 242, 493-497. 307-313. 9583-9586. 1980,46,249-256. 1976,5337-349.

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“…Diabetes mellitus is a multifactorial metabolic disease characterized by pancreatic beta cells dysfunction and insulin secretion deficiency resulting in hyperglycaemia . This hyperglycaemia provokes oxidative stress in beta cells, resulting in an elevated level of free radicals and cell death.…”

Section: Introductionmentioning

confidence: 99%