Beta cell disfunction as the main factor to determine glucose intolerance in insulin resistance patients

Tambascia, M.A.; Geloneze, Bruno; Rodovalho, S.; Pareja, JoseC.; Franco, DanielaM.; Repetto, E.M.

doi:10.1016/s0168-8227(00)81800-8

Cited by 2 publications

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“…Tambascia et al, (2000) relataram que alguns pacientes com graus muito altos de resistência insulínica, como é observado na obesidade, não mostram nenhum nível de intolerância à glicose devido a uma habilidade muito efi ciente de secretar insulina levando a um estado de hiperinsulinemia compensatória.…”

Section: Resultsunclassified

Avaliação do efeito hipoglicemiante de Cissus sicyoides em estudos clínicos fase II

Santos¹,

Modesto-Filho²,

Diniz³

et al. 2008

Rev. bras. farmacogn.

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RESUMO: O estudo objetivou realizar ensaios clínicos de fase II com o infuso das folhas deCissus sicyoides L (Vitaceae) para investigar a efi cácia terapêutica desse vegetal em voluntárias intolerantes à glicose (GIG n = 14) e diabéticas (GD n = 12) entre 30 e 59 anos de idade no Hospital Universitário Lauro Wanderley/UFPB. O chá foi preparado com 1g do pó das folhas secas, diluído em 150 mL de água quente por 10 minutos (uso popular), dose única, por um período de 7 dias (fase aguda). No GIG verifi cou-se a interação entre a glicemia e a insulina através do Teste Oral de Tolerância à Glicose, sem e com a ingestão do infuso. A glicemia e insulinemia foram determinadas nos tempos 0, 1, 2 e 3 h. Para o GD avaliou-se a variação espontânea da glicemia (em jejum e em repouso nos tempos 0, 1, 2 e 3 h) e o perfi l glicêmico (antes e 2 h após as refeições) na ausência e na presença do chá. No GIG, o chá das folhas teve atividade hipoglicemiante signifi cativa aos 120 minutos, porém, não houve aumento da insulinemia, além da fi siológica, sugerindo que esse efeito não ocorreu por liberação ou secreção da mesma. No GD o infuso não apresentou efeito hipoglicemiante signifi cativo. Unitermos:Cissus sicyoides, Vitaceae, estudos clínicos, atividade hipoglicemiante.ABSTRACT: "Evaluation of the hypoglycemic effect of Cissus sicyoides in phase II clinical trials". This study aimed to perform Phase II clinical trials with the infusion of the leaves of Cissus sicyoides L to investigate its therapeutic effectiveness in glucose-intolerant (GIG n = 14) and in type 2 diabetic (GD n = 12) volunteers, 30 to 59 years old, at Hospital Universitário Lauro Wanderley/UFPB. The tea was prepared with 1g of dust falling leaves diluted in 150 mL of hot water for 10 minutes (popular usage), in single doses, for 7 days (acute phase). In the GIG, the interaction between the glicemy and the insulin was verifi ed through two oral tests of glucose tolerance, with and without infusion's ingestion. The glicemy and the insulinemy were determined at 0, 1, 2, and 3 hours. For GD, the spontaneous variation of glicemy (during fasting and resting periods, at 0, 1, 2, and 3 hours), and the glicemic profi le (before and 2 hours after meals) were evaluated in the absence and in the presence of the tea. For GIG, the tea of the leaves revealed considerable hypoglycemic activity at 120 minutes; however there was no insulinemy increase, beyond the physiological, suggesting that this effect did not happen because of insulinemy's liberation or secretion. For GD, the tea did not demonstrate considerable hypoglycemic activity.

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Section: Resultsunclassified

Avaliação do efeito hipoglicemiante de Cissus sicyoides em estudos clínicos fase II

Santos¹,

Modesto-Filho²,

Diniz³

et al. 2008

Rev. bras. farmacogn.

View full text Add to dashboard Cite

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“…It was shown that dietary fiber improves the sensitivity to insulin in diabetics and non-diabetic [32,33] as well as in experimental animal models [34]. Research in spontaneously hypertensive rats predisposed to stroke suggested supplementation with psyllium soluble fiber effectively prevents IR by increasing the content of GLUT4 in the plasma membrane of skeletal muscle without activation of the PI3 kinase.…”

Section: Discussionmentioning

confidence: 99%

Effect of the yellow passion fruit peel flour (Passiflora edulis f. flavicarpa deg.) in insulin sensitivity in type 2 diabetes mellitus patients

Queiroz

Janebro

Cunha

et al. 2012

Nutr J

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BackgroundA study with the yellow passion fruit peel flour showed positive action in blood glucose control as therapies’ adjuvant in patients with type 2 diabetes mellitus. Therefore, we evaluated its effect on insulin sensitivity since there is a quest for studies that focus at better understanding of insulin resistance aspects in diabetic patients. Furthermore its relationship with chronic complications can also give good prospects for alternative treatments.MethodsA total of 43 type 2 diabetes volunteers (28 females and 15 males) ingested 30 g/day of the yellow passion fruit peel flour for two months. The levels of blood glucose and fasting insulin, HOMA index and glycated hemoglobin were measured for each patient before and after dietary supplementation.ResultsThere was a significant difference in the fasting blood glucose values (P = 0.000) and glycated hemoglobin (P = 0.032) after supplementation. It was also seen a reduction in HOMA IR (P = 0.005) in the supplemented group, however it was not observed changes in insulin values for females. HOMA beta (P = 0.000) showed significant increase in its values for the studied group.ConclusionsThe supplementation used decreased insulin resistance in type 2 diabetic patients, suggesting a positive action in blood glucose control as adjuvant therapy in conventional treatments.

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Beta cell disfunction as the main factor to determine glucose intolerance in insulin resistance patients

Cited by 2 publications

References 0 publications

Avaliação do efeito hipoglicemiante de Cissus sicyoides em estudos clínicos fase II

Avaliação do efeito hipoglicemiante de Cissus sicyoides em estudos clínicos fase II

Effect of the yellow passion fruit peel flour (Passiflora edulis f. flavicarpa deg.) in insulin sensitivity in type 2 diabetes mellitus patients

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