Beta-casein and its complexes with chitosan as nanovehicles for delivery of a platinum anticancer drug

Razmi, Mahdieh; Divsalar, Adeleh; Saboury, Ali Akbar; Izadi, Zhila; Haertlé, Thomas; Mansuri-Torshizi, H.

doi:10.1016/j.colsurfb.2013.08.022

Cited by 38 publications

(15 citation statements)

References 29 publications

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“…The clinical application of platinum-based anticancer drugs is greatly limited by their severe toxicity; however, a platinum(II) complex of bipyridine morpholine dithiocarbamate with nanoparticles composed of β-casein and chitosan demonstrated improved cytotoxicity and cellular uptake against colorectal cancer HCT116 cells, suggesting that this novel drug delivery system could enable the drugs to function in stable aqueous solutions and to be of use in targeted oral delivery applications. The nanoparticles demonstrated good colloidal stability and low cytotoxicity [ 79 ].…”

Section: Bioactive Proteins Of Milkmentioning

confidence: 99%

Milk Proteins—Their Biological Activities and Use in Cosmetics and Dermatology

Kazimierska

Kalinowska-Lis

2021

Molecules

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Milk and colostrum have high biological potential, and due to their natural origin and non-toxicity, they have many uses in cosmetics and dermatology. Research is ongoing on their potential application in other fields of medicine, but there are still few results; most of the published ones are included in this review. These natural products are especially rich in proteins, such as casein, β-lactoglobulin, α-lactalbumin, lactoferrin, immunoglobulins, lactoperoxidase, lysozyme, and growth factors, and possess various antibacterial, antifungal, antiviral, anticancer, antioxidant, immunomodulatory properties, etc. This review describes the physico-chemical properties of milk and colostrum proteins and the natural functions they perform in the body and compares their composition between animal species (cows, goats, and sheep). The milk- and colostrum-based products can be used in dietary supplementation and for performing immunomodulatory functions; they can enhance the effects of certain drugs and can have a lethal effect on pathogenic microorganisms. Milk products are widely used in the treatment of dermatological diseases for promoting the healing of chronic wounds, hastening tissue regeneration, and the treatment of acne vulgaris or plaque psoriasis. They are also increasingly regarded as active ingredients that can improve the condition of the skin by reducing the number of acne lesions and blackheads, regulating sebum secretion, ameliorating inflammatory changes as well as bestowing a range of moisturizing, protective, toning, smoothing, anti-irritation, whitening, soothing, and antiaging effects.

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Section: Bioactive Proteins Of Milkmentioning

confidence: 99%

Milk Proteins—Their Biological Activities and Use in Cosmetics and Dermatology

Kazimierska

Kalinowska-Lis

2021

Molecules

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“…In some samples (Figure 4F) differences in morphology are observed, which might be due to interactions between aggregates of casein and chitosan. In this regard, it has been documented that casein and chitosan can interact to form soluble or insoluble complexes following Maillard reaction or ionic interactions, which has found several applications including drug delivery [23].…”

Section: Resultsmentioning

confidence: 99%

Inhibition of Listeria monocytogenes in Fresh Cheese Using Chitosan-Grafted Lactic Acid Packaging

et al. 2016

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Abstract:A chitosan from biologically obtained chitin was successfully grafted with D,L-lactic acid (LA) in aqueous media using p-toluenesulfonic acid as catalyst to obtain a non-toxic, biodegradable packaging material that was characterized using scanning electron microscopy, water vapor permeability, and relative humidity (RH) losses. Additionally, the grafting in chitosan with LA produced films with improved mechanical properties. This material successfully extended the shelf life of fresh cheese and inhibited the growth of Listeria monocytogenes during 14 days at 4˝C and 22% RH, whereby inoculated samples with chitosan-g-LA packaging presented full bacterial inhibition. The results were compared to control samples and commercial low-density polyethylene packaging.

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“…Magnetic nanoparticles include metallic, bimetallic, and superparamagnetic iron oxide nanoparticles, which have reactive surface that can be coated with biocompatible polymers and loaded with therapeutic agents [70]. In vitro [35] Magnetite Fe 3 O 4 was chosen as a magnetic nucleus because of its high initial magnetic susceptibility and magnetic saturation.…”

Section: Chitosan-bound Fe 3 O 4 Nanoparticlesmentioning

confidence: 99%

Application of Chitosan-Based Nanocarriers in Tumor-Targeted Drug Delivery

et al. 2014

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Cancer is one of the major malignant diseases in the world. Current anti tumor agents are restricted during the chemotherapy due to their poor solubility in aqueous media, multidrug resistance problems, cytotoxicity, and serious side effects to healthy tissues. Development of targeted drug nanocarriers would enhance the undesirable effects of anticancer drugs and also selectively deliver them to cancerous tissues. Variety of nanocarriers such as micelles, polymeric nanoparticles, liposomes nanogels, dendrimers, and carbon nanotubes have been used for targeted delivery of anticancer agents. These nanocarriers transfer loaded drugs to desired sites through passive or active efficacy mechanisms. Chitosan and its derivatives, due to their unique properties such as hydrophilicity, biocompatibility, and biodegradability, have attracted attention to be used in nanocarriers. Grafting cancer-specific ligands onto the Chitosan nanoparticles, which leads to ligand-receptor interactions, has been successfully developed as active targeting. Chitosan-conjugated components also respond to external or internal physical and chemical stimulus in targeted tumors that is called environment triggers. In this study, mechanisms of targeted tumor deliveries via nanocarriers were explained; specifically, chitosan-based nanocarriers in tumor-targeting drug delivery were also discussed.

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Beta-casein and its complexes with chitosan as nanovehicles for delivery of a platinum anticancer drug

Cited by 38 publications

References 29 publications

Milk Proteins—Their Biological Activities and Use in Cosmetics and Dermatology

Milk Proteins—Their Biological Activities and Use in Cosmetics and Dermatology

Inhibition of Listeria monocytogenes in Fresh Cheese Using Chitosan-Grafted Lactic Acid Packaging

Application of Chitosan-Based Nanocarriers in Tumor-Targeted Drug Delivery

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