Beta-carotene studies in Spirulina

Seshadri, Chetan; Umesh, B.V.; Manoharan, Ranjith Kumar

doi:10.1016/0960-8524(91)90140-f

Cited by 34 publications

(16 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The observed immunomodulatory effect of Spirulina may be attributed to the presence of b-carotene [18], vitamins C and E, and the brilliant blue polypeptide pigment phycocyanin [19]. Immunomodulation by using natural products can provide an alternative to conventional therapy for a variety of diseases, especially when the host defence mechanism has to be activated under the conditions of impaired immune response or when a selective immunosuppression is desired in situations like autoimmune disorders.…”

Section: Discussionmentioning

confidence: 96%

Appraisal of immunomodulatory potential of Spirulina fusiformis: an in vivo and in vitro study

Rasool

Sabina

2008

J Nat Med

View full text Add to dashboard Cite

In recent years, Spirulina has gained more and more attention from medical scientists as a nutraceutical and a source of potential pharmaceuticals. The present study was conducted to elucidate the immunomodulatory effect of Spirulina fusiformis (a cyanobacterium of the family Oscillatoriaceae) in vivo and in vitro. The in vivo effect of S. fusiformis (400 or 800 mg/kg body wt.) on humoral immune response, cell-mediated immune response and tumour necrosis factor alpha was investigated in mice. We also evaluated the effect of S. fusiformis (50 or 100 microg/ml) in vitro on mitogen (phytohaemagglutinin)-induced T lymphocyte proliferation in heparinized human peripheral blood. For comparison, dexamethasone was used as a standard. In mice, S. fusiformis (400 or 800 mg/kg body wt.) administration significantly inhibited the humoral immune response, cell-mediated immune response (delayed-type hypersensitivity reaction (DTH)) and tumour necrosis factor alpha in a dose-dependent manner. In vitro, S. fusiformis (50 or 100 microg/ml) decreased the mitogen (phytohaemagglutinin)-induced T lymphocyte proliferation in a concentration-dependent manner when compared with control cells. These observations clearly suggest that S. fusiformis has a remarkable immunosuppressive effect, which provides a scientific validation for the popular use of this drug, and helped us in further work on investigating its complete mechanism of action.

show abstract

Section: Discussionmentioning

confidence: 96%

Appraisal of immunomodulatory potential of Spirulina fusiformis: an in vivo and in vitro study

Rasool

Sabina

2008

J Nat Med

View full text Add to dashboard Cite

show abstract

“…This suppressing effect of Spirulina fusiformis could be due to its antioxidant constituents such as b-carotene, 39) Vitamins C, E, 40) and other micronutrients. 41) However, further investigation on its effectiveness and mechanism are warranted before Spirulina fusiformis to be used as a supplement for the treatment of rheumatoid arthritis and is on the way.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory Effect of Spirulina fusiformis on Adjuvant-Induced Arthritis in Mice

Rasool

Sabina

Balaji

2006

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

The present study was carried out to evaluate the anti-inflammatory effect of Spirulina fusiformis on adjuvant-induced arthritis in mice. Arthritis was induced by intra dermal injection of complete freund's adjuvant (0.1 ml) into the right hind paw of Swiss albino mice. Spirulina fusiformis (800 mg/kg/b.wt) was orally administered for 8 d (from 11th to 18th day) to arthritic animals after adjuvant injection. The anti-inflammatory activity of Spirulina fusiformis was assessed by measuring paw volume, body weight, levels of lysosomal enzymes, tissue marker enzymes and glycoproteins in control and experimental animals. In adjuvant-induced arthritic animals, the levels of lysosomal enzymes, tissue marker enzymes, glycoproteins and the paw volume were increased significantly. However the body weight was found to be reduced when compared to control animals. Oral administration of Spirulina fusiformis (800 mg/kg/b.wt) significantly altered these above physical and biochemical changes observed in arthritic animals to near normal conditions. Hence results of this study clearly indicate that Spirulina fusiformis has promising anti-inflammatory activity against adjuvant-induced arthritic animals.

show abstract

“…It is known to have a high content of protein (Kapoor, 1994) and natural bio-chelated vitamins, especially ␤-carotene. (Prescott, 1978;Seshadri, 1991). It is also rich in essential fatty acids and natural pigments.…”

Section: Introductionmentioning

confidence: 97%

Modulatory Influence of Spirulina fusiformis on 7,12-Dimethylbenz(a)anthracene Induced Papillomagenesis in the Skin of Mice

Mittal

Kumar

Rao³

1998

Pharmaceutical Biology

View full text Add to dashboard Cite

The chemopreventive properties of a Spirulina fusiformis (blue green algae) suspension in olive oil on 7,12-dimethylbenz(a)anthracene (DMBA) induced skin papillomagenesis in female Swiss albino mice are being reported. A significant reduction in the values of tumor incidence, tumor burden and cumulative number of papillomas was observed in mice treated orally with Spirulina fusiformis suspension continuously at pre-, peri-and post-initiation stages of papillomagenesis as compared to the control group. Treatment of Spirulina fusiformis suspension by oral gavage for 15 days resulted in a significant decrease in the cytochrome P-450 content of the liver (p Ͻ 0.01). Conversely, glutathione S-transferase activity was observed to be significantly elevated as compared with the control group (p Ͻ 0.1) following treatment with Spirulina fusiformis suspension.

show abstract

Beta-carotene studies in Spirulina

Cited by 34 publications

References 1 publication

Appraisal of immunomodulatory potential of Spirulina fusiformis: an in vivo and in vitro study

Appraisal of immunomodulatory potential of Spirulina fusiformis: an in vivo and in vitro study

Anti-inflammatory Effect of Spirulina fusiformis on Adjuvant-Induced Arthritis in Mice

Modulatory Influence of Spirulina fusiformis on 7,12-Dimethylbenz(a)anthracene Induced Papillomagenesis in the Skin of Mice

Contact Info

Product

Resources

About