Beta-blockers in cirrhosis: Do they have benefits beyond the prevention of variceal bleeding?

Selvan, Senthamizh; Aggarwal, Rakesh

doi:10.4103/0970-258x.303615

Cited by 1 publication

(2 citation statements)

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“…This accounts for the suggestion that HBV vaccination may be started at 6 weeks of age if it is not possible to deliver the first dose at birth, with other vaccines. 7 This presumption is based on a study done in Delhi by Nayak et al 8 in 8,575 pregnant women. They found that 3.7% (N 5 322) women were HBsAg positive and just 19% of babies born to these HBsAg positive mothers got infected with HBV, compared with 3% of those born to HBsAg negative mothers.…”

Section: Introductionmentioning

confidence: 99%

“…By applying mathematical calculation, it was suggested that considering the population prevalence of 3.7%, 14% of all HBV carriers in India would have acquired HBV through vertical route and the remaining 86% through horizontal route. 7 In a study of 116 children with CHB from Delhi, 9 it was shown that two-thirds of children were in the immunetolerant phase of HBV infection (characteristics of perinatally acquired HBV), and in 74% of cases the mother is the source of infection. Our experience in 203 children also substantiates the same results (56% were in the immune-tolerant phase of HBV and mothers were the source in 68% of cases).…”

Section: Introductionmentioning

confidence: 99%

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Hepatitis B Transmission: Is Vertical Transmission the Major Route in Intermediate Endemic Areas? A Proof-of-Concept Study Based on Mother–Child Genotypes

Poddar

Benjamin

Aggarwal

et al. 2021

The American Journal of Tropical Medicine and Hygiene

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The route of hepatitis B transmission is believed to be horizontal in India, though pediatric studies showed mother as source in the majority of chronic HBV (CHB) cases. We aimed at establishing the fact that mother–child transmission is the main route of acquisition by documenting genotypically identical viruses in mother–child pairs. Blood samples of consecutive children (≤18 years) with CHB and high DNA (>10,000 IU/mL) and their positive mother were collected from January 2013 to December 2015. Polymerase chain reaction (PCR) products of HBV-DNA were amplified and sequenced by using BigDye Terminator Cycle Sequencing Kit v3.1 and aligned with previously described sequences in the region of interest for genotypes A to G by using BioEdit software. Phylogenetic tree was generated using p-distance algorithm in MEGA software version 6. Genotyping of 59 (33 children and 26 mothers) subjects include genotype A in 24 (40.7%) and genotype D in 35 (59.3%). Both mother–child pair genotyping was possible in 25. The median age of 25 children (20 males) was 9 (interquartile range, IQR: 4–11). The distribution of genotypes among mother–child pairs was similar. The concordance between children and their mothers was 24 of 25 (96%). Evolutionary analyses showed significant similarities between mother and child sequences for both genotype A and D, suggesting thereby the same virus. In conclusion, mother–baby transmission seems to be the major route of acquisition of HBV in children in India and near-complete homology in genetic sequences between mother–child pairs is definite proof for that. However, a larger epidemiological study is required to substantiate our findings.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%