Beta blockers for stable angina

Dong, Bi Rong; Wu, Taixiang; Yue, Jirong; Liu, Guan Jian; Shu, Defen

doi:10.1002/14651858.cd005152

Cited by 1 publication

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References 14 publications

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“…The following MEDLINE search strategy was used and adapted for the different databases, 16 and the search terms are given in Supplementary Table 1.…”

Section: Search Strategymentioning

confidence: 99%

The impact of beta-blockers on mortality in stable angina: a meta-analysis

Huang

Fox

2012

Scott Med J

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Beta-blockers are recommended as first-line symptomatic treatment for stable angina. However, their impact on mortality outside the context of myocardial infarction is unknown. We performed a meta-analysis of all randomized trials of beta-blockers in stable angina. Medical databases and cardiology journals were searched for relevant randomized clinical trials. The primary outcome was cardiovascular mortality, separately considering trials of beta-blockers versus placebo and beta-blockers versus other antianginals. We conducted a subgroup analysis on cardioselective versus non-cardioselective beta-blockers and calcium channel antagonists versus nitrates. We calculated odds ratios (ORs) and confidence intervals (CIs) using Peto's method. We found no statistically significant evidence that beta-blockers impact on mortality when compared with placebo (OR, 0.42; CI , 0.15-1.21) or other antianginals (OR, 0.98; CI, 0.86-1.10), or all others (OR, 0.97; CI, 0.86-1.09). There was a trend for cardioselective beta-blockers to have a greater improvement in mortality when compared with placebo and to have greater impact than non-calcium channel antagonists. Beta-blockers do not have statistically significant impact on mortality versus placebo or versus other active comparators. The findings exclude a benefit of 15% or greater and a hazard of 10% or greater. The impact of cardioselectivity requires further study.

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“…The following MEDLINE search strategy was used and adapted for the different databases, 16 and the search terms are given in Supplementary Table 1.…”

Section: Search Strategymentioning

confidence: 99%

The impact of beta-blockers on mortality in stable angina: a meta-analysis

Huang

Fox

2012

Scott Med J

View full text Add to dashboard Cite

show abstract

Beta blockers for stable angina

Cited by 1 publication

References 14 publications

The impact of beta-blockers on mortality in stable angina: a meta-analysis

The impact of beta-blockers on mortality in stable angina: a meta-analysis

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