Beta-blocker therapy for dynamic left-ventricular outflow tract obstruction

Al-Nasser, Faisal; Duncan, Alison; Sharma, Rakesh; O’Sullivan, Christine; Coats, Andrew J.S.; Anker, Stefan D.; Henein, Michael Y.

doi:10.1016/s0167-5273(02)00312-1

Cited by 31 publications

(31 citation statements)

References 12 publications

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“…This management modality has also resulted in a regression of myocardial hypertrophy in mild hypertensive patients with LVH. Al-Nasser et al 35 have shown that b-blocker therapy has a beneficial effect on the reduction of LVOT gradient and rate-pressure product provoked by pharmacologic stress in patients with focal hypertrophy of LV base (all hypertensive but one subject). The effects were similar in patients with hypertrophic cardiomyopathy.…”

Section: Introductionmentioning

confidence: 99%

Quantitative left ventricular contractility analysis under stress: a new practical approach in follow-up of hypertensive patients

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et al. 2010

J Hum Hypertens

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Excessive sympathetic activity and stress-induced left ventricular (LV) hypercontractility have been described in hypertensive LV hypertrophy. Recent quantitative data have shown that hypertensive LV hypertrophy is associated with preserved global LV function. However, progression of uncontrolled hypertension have detrimental effects on both the ejection fraction (EF) and LV contractile response to stress. Hypertensive LV hypertrophy has some common characteristics, including preserved global LV systolic function and LV volume with heart failure with preserved EF (HFPEF), which makes it difficult to differentiate between the two conditions at rest. Studies suggest that adopting an efficient antihypertensive therapy regimen may positively effect on the LV contractile capability in patients with long-standing hypertension. Evaluation of quantitative LV contractility under stress may be beneficial to differentiate between the hypertensive LV hypertrophy and HFPEF. It may also assist in developing a more effective modality in medical management of patients with hypertensive heart disease.

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Section: Introductionmentioning

confidence: 99%

Quantitative left ventricular contractility analysis under stress: a new practical approach in follow-up of hypertensive patients

Yalçın

Küçukler

et al. 2010

J Hum Hypertens

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“…Negative inotropic therapy, which is known to be beneficial in the management of HCM, may represent an adequate therapeutic approach in selected patients with DLVOTO identified by stress echocardiography [26].…”

Section: Introductionmentioning

confidence: 99%