beta-Adrenergic stimulation of skeletal muscle metabolism in relation to weight reduction in obese men

Blaak, Ellen E.; Baak, Marleen A. van; Kemerink, Gerrit J.; Pakbiers, M. T. W.; Heidendal, G. A. K.

doi:10.1152/ajpendo.1994.267.2.e316

Cited by 50 publications

(67 citation statements)

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“…It should be mentioned that there are major differences in catecholamine-induced lipolysis between depots (subcutaneous vs visceral and gluteofemoral) and also gender differences in body fat distribution. [43][44][45] Our data indicate that variability in codon 16 of the ADRB2 gene may contribute to a reduced in vivo b-adrenoceptor-mediated lipolysis and fat oxidation, [1][2][3][4] indicating that these blunted responses may be important primary factors in obesity.…”

Section: Discussionmentioning

confidence: 70%

“…In vivo studies have shown that the development or maintenance of increased adipose tissue stores might be promoted by a blunted lipolytic response and fat oxidation after b-adrenergic stimulation or exercise in obese or obese type 2 diabetic subjects. [1][2][3][4] This blunted b-adrenoceptor-mediated lipolysis and fat oxidation persisted after weight reduction, indicating that this disturbance may be an early, even primary factor, in the development or maintenance of increased adipose stores. 1 There are indications that the blunted b-adrenergically mediated lipolysis in obesity may be related to an impaired function or a reduced number of adipocyte beta-2 (b 2 ) adrenoceptors.…”

Section: Introductionmentioning

confidence: 95%

“…[1][2][3][4] This blunted b-adrenoceptor-mediated lipolysis and fat oxidation persisted after weight reduction, indicating that this disturbance may be an early, even primary factor, in the development or maintenance of increased adipose stores. 1 There are indications that the blunted b-adrenergically mediated lipolysis in obesity may be related to an impaired function or a reduced number of adipocyte beta-2 (b 2 ) adrenoceptors. 5,6 b 2 -Adrenoceptors are stimulatory G-protein-coupled (G s ) receptors.…”

Section: Introductionmentioning

confidence: 95%

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Association of a beta-2 adrenoceptor (ADRB2) gene variant with a blunted in vivo lipolysis and fat oxidation

et al. 2006

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Background and aims: Obesity is associated with a blunted b-adrenoceptor-mediated lipolysis and fat oxidation. We investigated whether polymorphisms in codon 16, 27 and 164 of the b 2 -adrenoceptor gene (ADRB2) and exon 10 of the G protein b 3 -subunit gene (GNB3) are associated with alterations in in vivo lipolysis and fat oxidation. Design and methods: Sixty-five male and 43 female overweight and obese subjects (body mass index (BMI) range: 26.1-48.4 kg/m 2 ) were included. Energy expenditure (EE), respiratory quotient (RQ), circulating free fatty acid (FFA) and glycerol levels were determined after stepwise infusion of increasing doses of the non-selective b-agonist isoprenaline (ISO). Results: In women, the Arg16 allele of the ADRB2 gene was associated with a blunted increase in circulating FFA, glycerol and a decreased fat oxidation during ISO stimulation. In men, the Arg16 allele was significantly associated with a blunted increase in FFA but not in glycerol or fat oxidation. Conclusion: These results suggest that genetic variation in the ADRB2 gene is associated with disturbances in in vivo b-adrenoceptor-mediated lipolysis and fat oxidation during b-adrenergic stimulation in overweight and obese subjects; these effects are influenced by gene-gender interactions.

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Section: Discussionmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 95%

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Association of a beta-2 adrenoceptor (ADRB2) gene variant with a blunted in vivo lipolysis and fat oxidation

et al. 2006

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“…A blunted fat oxidation response to b-androgenic stimulation may be a primary factor for increased fat stores and maintaining adipose tissue deposits following weight loss (Blaak et al, 1994b). UCP2 activity increases with increased blood lipid circulation.…”

Section: High-protein Diet Following Ovariohysterectomymentioning

confidence: 99%

Ovariohysterectomy alters body composition and adipose and skeletal muscle gene expression in cats fed a high-protein or moderate-protein diet

Vester

Sutter

Keel

et al. 2009

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The objective of this study was to measure changes in body composition, physical activity and adipose and skeletal muscle gene expression of cats fed a high-protein (HP) diet or moderate-protein (MP) diet, following ovariohysterectomy. Eight cats were randomized onto HP or MP diets and were fed those diets for several months prior to baseline. All cats underwent an ovariohysterectomy at baseline (week 0) and were allowed ad libitum access to dietary treatments for 24 weeks. Food intake was measured daily, and BW and body condition score were measured weekly. Blood, adipose and skeletal muscle tissue samples were collected, physical activity was measured, and body composition was determined using DEXA (dual-energy X-ray absorptiometry) at weeks 0, 12 and 24. Caloric intake increased soon after ovariohysterectomy, resulting in increased ( P , 0.05) BW at weeks 12 and 24 compared to week 0. Body condition score and body fat percentage increased ( P , 0.05) over time. Blood glucose increased ( P , 0.05) linearly over time. Non-esterified fatty acids were decreased ( P , 0.05) at weeks 12 and 24 compared to week 0. Blood leptin increased ( P , 0.05) over time. Total physical activity decreased ( P , 0.05) from week 0 to weeks 12 and 24 in all cats. Adipose tissue mRNA abundance of adiponectin, hormone sensitive lipase, toll-like receptor-4, uncoupling protein-2 (UCP2) and vascular endothelial growth factor decreased ( P , 0.05) linearly over time, regardless of diet. Skeletal muscle mRNA abundance for glucose transporter-1, hormone sensitive lipase and UCP2 were decreased ( P , 0.05), regardless of dietary treatment. Our research noted metabolic changes following ovariohysterectomy that are in agreement with gene expression changes pertaining to lipid metabolism. Feeding cats ad libitum after ovariohysterectomy is inadvisable.

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“…Impairments in the ability of the skeletal muscle to use FFA have also been reported in obese subjects during postabsorptive conditions (12) and ␤-adrenergic stimulation (13), suggesting that an impaired capacity to use fat may be one of the factors linking obesity to type 2 diabetes mellitus by promoting skeletal muscle insulin resistance and hyperglycemia. Additionally, persistent impairments in FFA utilization have been previously reported after weight loss in obese subjects (14,15), suggesting that these defects could also be primary to the obese state. This is consistent with the findings that a decreased reliance on lipid oxidation is a risk factor for weight gain (16) and for weight regain after weight loss (17).…”

mentioning

confidence: 91%

beta-Adrenergic stimulation of skeletal muscle metabolism in relation to weight reduction in obese men

Abstract: (1994). beta-Adrenergic stimulation of skeletal muscle metabolism in relation to weight reduction in obese men. American Journal of Physiology, 267(2), E316-E322.

Cited by 50 publications

References 3 publications

Association of a beta-2 adrenoceptor (ADRB2) gene variant with a blunted in vivo lipolysis and fat oxidation

Association of a beta-2 adrenoceptor (ADRB2) gene variant with a blunted in vivo lipolysis and fat oxidation

Ovariohysterectomy alters body composition and adipose and skeletal muscle gene expression in cats fed a high-protein or moderate-protein diet

Weight Reduction and the Impaired Plasma-Derived Free Fatty Acid Oxidation in Type 2 Diabetic Subjects

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