Beta adrenergic receptors in pigmented ciliary processes.

Trope, Graham E.; Clark, Barry

doi:10.1136/bjo.66.12.788

Cited by 43 publications

(10 citation statements)

References 20 publications

(3 reference statements)

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“…15 It has been demonstrated that only beta-2 receptors are found in the ciliary process of sheep. 27 To our knowledge, there are no accounts of the existence of alpha-1 receptors in the ciliary process of this species; this could explain the inefficacy of these drugs for pupil dilation.…”

Section: Discussionmentioning

confidence: 91%

Effects of different mydriatics on intraocular pressure, pupil diameter, and ruminal and intestinal motility in healthy sheep

Ribeiro

Crivelaro

Teixeira

et al. 2013

Veterinary Ophthalmology

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Section: Discussionmentioning

confidence: 91%

Effects of different mydriatics on intraocular pressure, pupil diameter, and ruminal and intestinal motility in healthy sheep

Ribeiro

Crivelaro

Teixeira

et al. 2013

Veterinary Ophthalmology

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“…This pigment binds several radioligands, causing a marked increase in non specific binding (5,7,11). This increases the "noise" on autoradiograms such that the putative specific binding sites on adjacent tissues cannot be detected.…”

Section: Discussionmentioning

confidence: 99%

Beta Adrenergic Binding Sites in the Human Eye: An Autoradiographic Study

Elena¹,

Denis²,

Kosina-Boix³

et al. 1990

Journal of Ocular Pharmacology and Therapeutics

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Beta adrenergic binding sites were localized and characterized in the human eye by means of "in vitro" autoradiography, using [125I] (-) iodocyanopindolol (125ICYP) as radioligand.Binding sites were visualized by apposition of isotope sensitive film to slide mounted eye sections. Receptor sites were present in the extraocular muscles, in the conjunctiva, in the epithelium and endothelium of the cornea, in the trabeculum and in the ciliary muscle. They were also present in the lens epithelium and in the retina. The pigmented ocular structures were heavily labelled but the binding was nonspecific. Characterization of these binding sites was achieved by testing the ability of selective adrenergic compounds to displace 125ICYP binding. These studies suggested that the majority of adrenergic binding sites in nonpigmented structures of human eye were of a beta2 type.

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“…ß-blockers inhibit either ß1-, or both ß1-and ß2-adrenoceptors [131]. Since these receptors are abundantly expressed in the ciliary processes, this may result in an excess of noradrenaline, which may, in turn, induce vasoconstriction and decreases in blood supply to the ciliary body, aiding in the reduction of AH production [132]. Alpha2-adrenergic receptor agonists work in a similar way, but are not often used as topical medications owing to their side effects.…”

Section: Traditional Topical Medications In the Management Of Glaucomamentioning

confidence: 99%

Open-angle glaucoma: therapeutically targeting the extracellular matrix of the conventional outflow pathway

O’Callaghan

Cassidy

Humphries

2017

Expert Opinion on Therapeutic Targets

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Introduction:Ocular hypertension in open-angle glaucoma is caused by a reduced rate of removal of aqueous humour (AH) from the eye, with the majority of AH draining from the anterior chamber through the conventional outflow pathway, comprising the trabecular meshwork (TM) and Schlemm's Canal. Resistance to outflow is generated, in part, by the extracellular matrix (ECM) of the outflow tissues. Current pressure-lowering topical medications largely suppress AH production, or enhance its clearance through the unconventional pathway. However, therapies targeting the ECM of the conventional pathway in order to decrease intraocular pressure have become a recent focus of attention. Areas covered: We discuss the role of ECM of the TM in outflow homeostasis and its relevance as a target for glaucoma therapy, including progress in development of topical eye formulations, together with gene therapy approaches based on inducible, virally-mediated expression of matrix metalloproteinases to enhance aqueous outflow. Expert opinion: There remains a need for improved glaucoma medications that more specifically act upon sites causative to glaucoma pathogenesis. Emerging strategies targeting the ECM of the conventional outflow pathway, or associated components of the cytoskeleton of TM cells, involving new pharmacological formulations or genetically-based therapies, are promising avenues of future glaucoma treatment. ARTICLE HISTORY

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Beta adrenergic receptors in pigmented ciliary processes.

Abstract: (±) propranolol, salbutamol, and practolol were investigated, and the receptors characterised by a computerassisted nonlinear, derivative-free regression procedure, separating out mixed receptor populations (h1/i2) as appropriate.

Cited by 43 publications

References 20 publications

Effects of different mydriatics on intraocular pressure, pupil diameter, and ruminal and intestinal motility in healthy sheep

Effects of different mydriatics on intraocular pressure, pupil diameter, and ruminal and intestinal motility in healthy sheep

Beta Adrenergic Binding Sites in the Human Eye: An Autoradiographic Study

Open-angle glaucoma: therapeutically targeting the extracellular matrix of the conventional outflow pathway

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