“…Therefore, agents capable of producing a beneficial effect on the vessel wall, preventing the development of atherosclerosis, or at least not stimulating atherogenesis, would seem to be preferable in the therapy of hypertensive patients. While the atherogenic properties of Orekhov/Tertov/Pivovarova beta-blockers were revealed in our cell model, it should, however, be noted that the atherogenicity of beta-blockers may not occur in vivo, since these agents produce numerous indirect positive effects on the vessel wall [24], and may reduce plaque rupture, thus, indirectly inhibiting thrombosis [25]. On the basis of our in vitro and ex vivo results, the ranking of antiatherosclerosis-related effects is amlodipine 1 verapamil 1 perindopril 1 propranolol.…”