Beta-2-transferrin and cerebrospinal fluid rhinorrhoea

Nandapalan, V.; Watson, Ian D.; Swift, A. C.

doi:10.1111/j.1365-2273.1996.tb01737.x

Cited by 91 publications

(63 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recently, testing for ␤ 2 -transferrin has become more commonly used in the clinical setting (144,197,219). This test is reported to have high specificity, as this protein is found only in CSF, vitreous humor, and inner ear perilymph.…”

Section: Examinationmentioning

confidence: 99%

Epidemiology, Etiology, Pathogenesis, and Diagnosis of Recurrent Bacterial Meningitis

2008

View full text Add to dashboard Cite

SUMMARY Recurrent bacterial meningitis is a rare phenomenon and generally poses a considerable diagnostic challenge to the clinician. Ultimately, a structured approach and early diagnosis of any underlying pathology are crucial to prevent further episodes and improve the overall outcome for the affected individual. In this article, we are reviewing the existing literature on this topic over the last two decades, encompassing 363 cases of recurrent bacterial meningitis described in 144 publications. Of these cases, 214 (59%) were related to anatomical problems, 132 (36%) were related to immunodeficiencies, and 17 (5%) were related to parameningeal infections. The review includes a detailed discussion of the underlying pathologies and microbiological aspects as well as recommendations for appropriate diagnostic pathways for investigating this unusual entity.

show abstract

Section: Examinationmentioning

confidence: 99%

Epidemiology, Etiology, Pathogenesis, and Diagnosis of Recurrent Bacterial Meningitis

2008

View full text Add to dashboard Cite

show abstract

“…Detection of b-2-transferrine in nasal discharge in cases of rinorrhoea is a sensitive and specific method to confirm the presence of a CSF leak [21][22][23]. Optimum imaging is performed using thin-slice CT of the skull base and is the initial imaging of choice [5,9,24].…”

Section: Discussionmentioning

confidence: 99%

Community-Acquired Recurrent Bacterial Meningitis in Adults

Adriani

Beek

Brouwer

et al. 2007

Clinical Infectious Diseases

View full text Add to dashboard Cite

Background. Community-acquired recurrent bacterial meningitis in adults is a relatively rare disease. All previous data were derived from small retrospective case series.Methods. We prospectively evaluated episodes of recurrent bacterial meningitis in a nationwide cohort study in The Netherlands.Results. Thirty-four episodes of recurrent bacterial meningitis were identified among 31 patients; 3 patients experienced 2 episodes during the study period. The mean age was 43 years, and 25 (74%) of 34 episodes occurred in men. Predisposing conditions were involved in 26 (77%) of 34 episodes; the most common predisposing conditions were remote head injury (17 [53%] of 32 episodes) and cerebrospinal fluid (CSF) leakage (9 [32%] of 28 episodes). Lumbar puncture revealed an individual CSF indicator of bacterial meningitis for almost all episodes (88%). The outcome was death for 5 (15%) of 34 episodes; 1 additional patient had a suboptimal score on the Glasgow Outcome Scale.Conclusion. We conclude that most patients with recurrent meningitis are male and have predisposing conditions, which, in most cases, are remote head injury or CSF leakage.

show abstract

“…This is usually performed by high-resolution computerized tomography to delineate a bony defect, although in a proportion of patients none is found. Under these circumstances it is wise to confirm that the leaking fluid is indeed CSF using immunofixation of ß 2 -transferrin [2,3]. Fluorescein lumbar puncture can be useful in detecting the site of a CSF leak where computerized tomography has failed to define a defect.…”

Section: Introductionmentioning

confidence: 99%