Beta-1 Receptor Blockade With Metoprolol (Met) Abolishes the Increase in Plasma Renin Activity (Pra) With Exercise in Dogs

Zambraski, Edward J.; Lakas, C. S.

doi:10.1249/00005768-198202000-00026

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“…The influence of hemodynamic pertubations on the passage of charged mscromolecules across the filtration membrane is perhaps of more importance in our study than a change in molecular charge as albuminuria was effectively blocked by the administration of phenoxybenzamine despite concomitant decreases of plasma pH. The increase of plasma renin activity during severe exercise in dogs was effectively prevented by the administration of metoprolol, a 31-adrenergic blocking agent, prior to exercise (17). In rats, the intrarenal renin-angiotensin system appears to induce proteinuria via a decrease of glomerular capillary plasma flow rate mediateI by angiotensin 11 (1,3).…”

Section: Discussionmentioning

confidence: 76%

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Effects of NaHCO₃, α- and β-Adrenergic Blockade on Albuminuria after Swimming in Splenectomized Dogs

Ja¹,

Nicaise²,

Sanders³

et al. 1984

Int J Sports Med

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The albuminuria occurring after swimming in splenectomized dogs was investigated. Swimming in splenectomized dogs induces metabolic acidosis, a decrease in renal vascular conductance, and an increase in plasma renin activity, all three factors possibly implicated in the occurrence of albuminuria. The administration of sodium bicarbonate prior to swimming reduced the magnitude of the acidosis and eliminated the increase in albuminuria after swimming. Phenoxybenzamine, an alpha-adrenergic blocking agent that maintains the renal blood flow during exercise also blocked the increase in albuminuria despite a decrease of blood pH during swimming. However, after metoprolol, a beta 1-adrenergic blocking agent that blocks the rise in plasma renin activity during exercise, swimming causes a threefold increase in albuminuria (P less than 0.01). The albuminuric response to swimming preceded by saline was also significant (P less than 0.05). It is likely that post-swimming albuminuria in splenectomized dogs is linked to the decrease of renal vascular conductance or to the decrease in blood pH rather than to the rise in plasma renin activity.

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Section: Discussionmentioning

confidence: 76%

“…The a-adrenergic blocking agent phenoxybenzamine was used to maintain renal vascular conductance during swimming (9). A 131-adrenergic blocking agent, metoprolol, was used to inhibit the renin release during exercise (17).…”

Section: Introductionmentioning

confidence: 99%

Effects of NaHCO₃, α- and β-Adrenergic Blockade on Albuminuria after Swimming in Splenectomized Dogs

Ja¹,

Nicaise²,

Sanders³

et al. 1984

Int J Sports Med

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show abstract

Beta-1 Receptor Blockade With Metoprolol (Met) Abolishes the Increase in Plasma Renin Activity (Pra) With Exercise in Dogs

Cited by 1 publication

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Effects of NaHCO₃, α- and β-Adrenergic Blockade on Albuminuria after Swimming in Splenectomized Dogs

Effects of NaHCO₃, α- and β-Adrenergic Blockade on Albuminuria after Swimming in Splenectomized Dogs

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Beta-1 Receptor Blockade With Metoprolol (Met) Abolishes the Increase in Plasma Renin Activity (Pra) With Exercise in Dogs

Cited by 1 publication

References 0 publications

Effects of NaHCO3, α- and β-Adrenergic Blockade on Albuminuria after Swimming in Splenectomized Dogs

Effects of NaHCO3, α- and β-Adrenergic Blockade on Albuminuria after Swimming in Splenectomized Dogs

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Effects of NaHCO₃, α- and β-Adrenergic Blockade on Albuminuria after Swimming in Splenectomized Dogs

Effects of NaHCO₃, α- and β-Adrenergic Blockade on Albuminuria after Swimming in Splenectomized Dogs