“…The initial identification of lactate in the nucleus [9] was followed by studies showing that phosphorylation of LDH [ 2 2 _ T D $ D I F F ] on Tyr238 is important for its nuclear translocation [42,55]. Nuclear LDH binds to DNA [56] and interacts with DNA polymerases /, d and e, stimulating DNA synthesis and post-UV radiation DNA repair [42].…”