Bestimmung von Dequaliniumverbindungen in biologischem Material

Abstract

Determination of DequaPnium Compounds in Biological MaterialThe fluorimetric determination of dequalinium salts in biological material is investigated. After oral or intravenous application to rats and dogs only traces of unchanged dequalinium salts (chloride and acetate) are renal excreted. In addition the urine contains minor quantities of a metabolite, possibly the 2.2'-dicarboxylic acid derivative. Therefore no bactericide effect of the urine is to be expected after application of therapeutic doses of dequalinium acetate or chloride itself, but possibly by the reaction of unidentified metabolites of dequalinium.Von zahlreichen Polymethylen-bis(4-aminochinaldinium)-Derivaten1) 2, envies sich die Decamethylenverbindug (I) als besonders stark antimikrobiell wirksam3). Dequaliniumsalze, I, haben ein au5ergewohnlich breites Wirkungsspektrum. Wghrend

2-Amino-4-(2,4-dichlorophenyl)-6-ferrocenylpyridine-3-carbonitrile

“…In fact, it is now well established that the incorporation of ferrocene units in organic molecules confers significant new properties on these materials. Recently, ferrocenyl derivatives were reported to display antimalarial (Biot et al, 1997;Itoh et al, 2000), antitumor and DNA-cleaving (Lautens et al, 1996;Dell et al, 1998) activities. For these reasons, the synthesis of new compounds containing the ferrocenyl unit is important.…”

One‐pot, three‐component synthesis of spironaphthopyrano[2,3‐d]pyrimidine‐5,3′‐indolines in water

“…A number of heterocyclic compounds fused with pyrimidines are known for their varied biological activities [23–26]. Similarly, naphthopyran derivatives are an important class of compounds with excellent photochromic properties [27–29], some of which are also structural motifs present in many biologically active compounds [30–32]. For example, some naphthopyran derivatives could have potential applications in biochemical research as photoswitch tag compounds [33].…”